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In four out of six patients with chronic active hepatitis a significant decrease of lymphocytotoxicity was found after immunosuppressive therapy with oral prednisolone. A good correlation between the lymphocytotoxicity test and histological signs of activity suggests that a cell-mediated immune aggression is present in this disease.<\/jats:p>","DOI":"10.1136\/gut.19.3.189","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"189-193","source":"Crossref","is-referenced-by-count":28,"title":["Lymphocytotoxicity test against rabbit hepatocytes in chronic liver diseases."],"prefix":"10.1136","volume":"19","author":[{"given":"A","family":"Facchini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Stefanini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bernardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Miglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lab\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,3,1]]},"reference":[{"key":"ref_1","article-title":"Separation of leukocytes from blood and bone marrow","volume":"97","author":"Boyum, A.","year":"1968","unstructured":"Boyum A. (1968). Separation of leukocytes from blood and bone marrow. Scandinavian Journal of Laboratory and Clinical Investigation, Supp. 97.","journal-title":"Scandinavian Journal of Laboratory and Clinical Investigation, Supp"},{"key":"ref_2","first-page":"441","article-title":"Antibodydependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis","volume":"1","author":"Cochrane, A.M.G.; Moussouros, A.; Thomson, A.D.; Eddleston, A.L.W.F.; Williams, R.","year":"1976","unstructured":"Cochrane, A. M. G., Moussouros, A., Thomson, A. D., Eddleston, A. L. W. F., and Williams, R. (1976). Antibodydependent cell-mediated (K cell) cytotoxicity against isolated hepatocytes in chronic active hepatitis. Lancet, 1, 441-444.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/S0140-6736(74)90287-6","article-title":"Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis","volume":"2","author":"Eddleston, A.L.W.F.; Williams, R.","year":"1974","unstructured":"Eddleston, A. L. W. F., and Williams, R. (1974). Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis. Lancet, 2, 1543-1545.","journal-title":"Lancet"},{"key":"ref_4","volume-title":"The preparation and labelling of lymphocytes. In Handbook of Immunology, chapter 23","author":"Ford, W.D.; Hunt, S.V.","year":"1973","unstructured":"Ford, W. D., and Hunt, S. V. (1973). The preparation and labelling of lymphocytes. In Handbook of Immunology, chapter 23, edited by D. M. Weir. Blackwell: Oxford."},{"key":"ref_5","first-page":"457","article-title":"An immunofluorescence procedure for the detection of intracellular immunoglobulins","volume":"4","author":"Hijmans, W.; Schuit, H.R.E.; Klein, F.","year":"1969","unstructured":"Hijmans, W., Schuit, H. R. E., and Klein, F. (1969). An immunofluorescence procedure for the detection of intracellular immunoglobulins. Clinical and Experimental Imnmunology, 4, 457-472.","journal-title":"Clinical and Experimental Imnmunology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1056\/NEJM197603112941103","article-title":"Detection of a liver-membrane autoantibody in HBsAg -negative chronic active hepatitis","volume":"294","author":"Hopf, U.; Meyer zum Buschenfelde, K.H.; Arnold, W.","year":"1976","unstructured":"Hopf, U., Meyer zum Buschenfelde, K. H., and Arnold, W. (1976). Detection of a liver-membrane autoantibody in HBsAg -negative chronic active hepatitis. New England Journal of Medicine, 294, 578-582.","journal-title":"New England Journal of Medicine"},{"key":"ref_7","article-title":"Studies on the pathogenesis of chronic inflammatory liver disease","author":"Hopf, U.; Arnold, W.; Meyer zum Buschenfelde, K.H.; Forster, E.; Bolte, J.P.","year":"1975","unstructured":"Hopf, U., Arnold, W., Meyer zum Buschenfelde, K. H., Forster, E., and Bolte, J. P. (1975). Studies on the pathogenesis of chronic inflammatory liver disease."},{"key":"ref_8","first-page":"\"1","article-title":"Membrane-fixed IgG on isolated hepatocytes from patients","volume":"22","author":"Hopf, U.; Meyer zum Buschenfelde, K.H.; Freudenberg, J.","year":"1974","unstructured":"Membrane-fixed IgG on isolated hepatocytes from patients. Clinical and Experimrental Immunology, 22, 1-8. Hopf, U., Meyer zum Buschenfelde, K. H., and Freudenberg, J. (1974). Liver-specific antigens of different species. II Localisation of a membrane antigen at cell surface of isolated hepatocytes. Clinical and Experimental Immunology, 16, 117-124.","journal-title":"Clinical and Experimrental Immunology; Liver-specific antigens of different species. II Localisation of a membrane antigen at cell surface of isolated hepatocytes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJM197603112941110","article-title":"Two immunological reactions in the pathogenesis of hepatitis?","volume":"294","author":"Paronetto, F.; Popper, H.","year":"1976","unstructured":"Paronetto, F. and Popper, H. (1976). Two immunological reactions in the pathogenesis of hepatitis? New England Journal of Medicine, 294, 606-607.","journal-title":"New England Journal of Medicine"},{"key":"ref_10","first-page":"99","article-title":"Immunological studies in patients with chronic active hepatitis: cytotoxic activity of lymphocytes to autochthonous liver cells grown in tissue culture","volume":"19","author":"Paronetto, F.; Vernace, S.","year":"1975","unstructured":"Paronetto, F., and Vernace, S. (1975). Immunological studies in patients with chronic active hepatitis: cytotoxic activity of lymphocytes to autochthonous liver cells grown in tissue culture. Clinical and Experimental Immunology, 19, 99-104.","journal-title":"Clinical and Experimental Immunology"},{"key":"ref_11","article-title":"Immunofluorescent Test for the Detection of Autoantibodies. Booklet 1-13","author":"Roitt, I.M.; Doniach, D.","year":"1974","unstructured":"Roitt, I. M., and Doniach, D. (1974). Immunofluorescent Test for the Detection of Autoantibodies. Booklet 1-13. WHO: Geneva."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/252721a0","article-title":"Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis","volume":"252","author":"Thompson, A.D.; Cochrane, M.A.G.; McFarlane, I.G.; F., Eddleston A.L.W.; Williams, R.","year":"1974","unstructured":"Thompson, A. D., Cochrane, M. A. G., McFarlane, I. G., Eddleston A. L. W. F., and Williams, R. (1974). Lymphocyte cytotoxicity to isolated hepatocytes in chronic active hepatitis. Nature (Lond.), 252, 721-722.","journal-title":"Nature (Lond.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0016-5085(76)80150-3","article-title":"Alcoholic hepatitis: cell -mediated immunological response to alcoholic hyalin","volume":"70","author":"Zetterman, R.K.; Luisada-Opper, A.; Leevy, C.M.","year":"1976","unstructured":"Zetterman, R. K., Luisada-Opper, A., and Leevy, C. M. (1976). Alcoholic hepatitis: cell -mediated immunological response to alcoholic hyalin. 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