{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:02:34Z","timestamp":1792112554930,"version":"4.4.0"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1978,3]]},"abstract":"<jats:p>An experimental colitis in rabbits is described, following the intravenous injection of preformed immune complexes of human serum albumin (HSA) and anti-HSA into non-sensitised rabbits. Tissue damage was localised to the colon by the Auer technique of inducing local non-specific inflammation, by the rectal instillation of dilute formalin. Formalin alone gave transient changes that reverted to normal within 24 hours. In rabbits given intravenous immune complexes formed in antigen-excess, a severe colitis was initiated, with histological features including mucosal ulceration, mixed inflammatory cell infiltration in the lamina propria, and crypt abscess formation. It is possible that immune-complex damage may be one of the pathogenic mechanisms involved in human ulcerative colitis.<\/jats:p>","DOI":"10.1136\/gut.19.3.225","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"225-232","source":"Crossref","is-referenced-by-count":78,"title":["Immune-complex mediated colitis in rabbits. An experimental model."],"prefix":"10.1136","volume":"19","author":[{"given":"H J","family":"Hodgson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B J","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1978,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1084\/jem.32.4.427","article-title":"Local autoinoculation of the sensitised organism with foreign protein as a cause of abnormal reactions","volume":"32","author":"Auer, J.","year":"1920","unstructured":"Auer, J. (1920). Local autoinoculation of the sensitised organism with foreign protein as a cause of abnormal reactions. Journal of Experimental Medicine, 32, 427-444.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_2","first-page":"3233","article-title":"High-resolution density-gradient sedimentation analysis","volume":"131","author":"Britten, R.J.; Roberts, R.B.","year":"1960","unstructured":"Britten, R. J., and Roberts, R. B. (1960). High-resolution density-gradient sedimentation analysis. Science, 131, 3233.","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0016-5085(73)80090-3","article-title":"Enterobacterial common antigen-induced lymphocyte reactivity in inflammatory bowel disease","volume":"64","author":"Bull, D.M.; Ignaczak, T.F.","year":"1973","unstructured":"Bull, D. M., and Ignaczak, T. F. (1973). Enterobacterial common antigen-induced lymphocyte reactivity in inflammatory bowel disease. 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Journal of the American Medical Association, 153, 1069-1072.","journal-title":"Journal of the American Medical Association"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/00365517109095722","article-title":"Detection of the sedimentation coefficients of D-glucose-6-phosphate dehydrogenase from normal and deficient human erythrocytes by S-zonal ultracentrifugation","volume":"28","author":"Funding, L.; Steensgaard, J.","year":"1971","unstructured":"Funding, L., and Steensgaard, J. (1971). Detection of the sedimentation coefficients of D-glucose-6-phosphate dehydrogenase from normal and deficient human erythrocytes by S-zonal ultracentrifugation. Scandinavian Journal of Clinical and Laboratory Investigation, 28, 445-452.","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"ref_9","first-page":"556","article-title":"The Arthus phenomenom in the colon of rabbits. 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(1977)."},{"key":"ref_12","article-title":"Circulating immune complexes in inflammatory bowel disease","author":"Jewell, D.P.; MacLennan, I.C.M.","year":"1973","unstructured":"Jewell, D. P., and MacLennan, I. C. M. (1973). Circulating immune complexes in inflammatory bowel disease."},{"key":"ref_13","first-page":"913","article-title":"Histologic and immunohistochemical features of 'Auer' colitis in rabbits","volume":"43","author":"Kraft, S.C.; Fitch, F.W.; Kirsner, J.B.","year":"1963","unstructured":"Kraft, S. C., Fitch, F. W., and Kirsner, J. B. (1963). Histologic and immunohistochemical features of 'Auer' colitis in rabbits. American Journal ofPathology, 43, 913-927.","journal-title":"American Journal ofPathology"},{"key":"ref_14","first-page":"263","article-title":"Immunological studies in ulcerative colitis. III. 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S., and Allison, A. C. (1971). Antibacterial antibodies in rectal and colonic mucosa in ulcerative colitis. Lancet, 1, 249-251.","journal-title":"Journal of Biological Chemistry; Antibacterial antibodies in rectal and colonic mucosa in ulcerative colitis"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1084\/jem.117.5.717","article-title":"In vitro studies of ulcerative colitis, II. Cytotoxic action of white blood cells from patients on human fetal colon cells","volume":"117","author":"Perlmann, P.; Broberger, 0","year":"1963","unstructured":"Perlmann, P., and Broberger, 0. (1963). In vitro studies of ulcerative colitis, II. Cytotoxic action of white blood cells from patients on human fetal colon cells. 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Advances in Immunology, 1, 283-317.","journal-title":"Advances in Immunology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.19.3.225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:51:57Z","timestamp":1757274717000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.19.3.225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,3]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1978,3,1]]},"published-print":{"date-parts":[[1978,3]]}},"alternative-id":["10.1136\/gut.19.3.225"],"URL":"https:\/\/doi.org\/10.1136\/gut.19.3.225","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,3]]}}}