{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:13:02Z","timestamp":1765620782398,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1978,4]]},"abstract":"<jats:p>The absorption of carbenoxolone sodium has been studied in 15 patients with gastric ulcer and eight patients with duodenal ulcer treated for four weeks. Blood levels of carbenoxolone showed a log distribution, varied markedly between patients, and were significantly higher after Biogastrone tablets (300 mg\/day) than after Duogastrone capsules (200 mg\/day). Serum carbenoxolone levels were similar in patients taking Biogastrone tablets before or after meals, and in patients taking Biogastrone tablets or Duogastrone capsules with or without antacids following chronic administration. Serum carbenoxolone levels were similar in patients whose gastric ulcers had or had not healed after four weeks' treatment. Serum carbenoxolone was significantly higher in patients who developed oedema, and was significantly correlated with age and with fall in plasma potassium. Carbenoxolone may exert its metabolic effects systemically, but its ulcer-healing effects topically; additional studies are needed to test this hypothesis.<\/jats:p>","DOI":"10.1136\/gut.19.4.330","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"330-335","source":"Crossref","is-referenced-by-count":8,"title":["Serum carbenoxolone in patients with gastric and duodenal ulcer: Absorption, efficacy and side-effects."],"prefix":"10.1136","volume":"19","author":[{"given":"J H","family":"Baron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J N","family":"Gribble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,4,1]]},"reference":[{"key":"ref_1","first-page":"115","article-title":"Factors affecting the absorption of carbenoxolone in patients with peptic ulcer","volume-title":"Fourth Symnposium on Carbenoxolone","author":"Baron, J.H.; Gribble, R.J.N.; Rhodes, C.; Wright, P.A.","year":"1975","unstructured":"Baron, J. H., Gribble, R. J. N., Rhodes, C., and Wright, P. A. (1975). Factors affecting the absorption of carbenoxolone in patients with peptic ulcer. In Fourth Symnposium on Carbenoxolone, pp. 115-128. Edited by F. A. Jones and D. V. Parke. Butterworths: London."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/gut.9.1.42","article-title":"Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone","volume":"9","author":"Doll, R.; Langman, M.J.S.; Shawdon, H.H.","year":"1968","unstructured":"Doll, R., Langman, M. J. S., and Shawdon, H. H. (1968). Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone. Gut, 9, 42-45.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.2042-7158.1970.tb10550.x","article-title":"The absorption and excretion of carbenoxolone in man","volume":"22","author":"Downer, H.F.; Galloway, R.W.; Horwich, L.; Parke, D.V.","year":"1970","unstructured":"Downer, H. F., Galloway, R. W., Horwich, L., and Parke, D. V. (1970). The absorption and excretion of carbenoxolone in man. Journal of Pharmacy and Pharmacology, 22, 479-487.","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"ref_4","first-page":"203","volume-title":"Development of the Duogastrone capsule. In A Symposium on Carbenoxolone Sodium","author":"Galloway, R.","year":"1968","unstructured":"Galloway, R. (1968). Development of the Duogastrone capsule. In A Symposium on Carbenoxolone Sodium, pp. 203-208. Edited by J. M. Robson and F. M. Sullivan. Butterworths: London."},{"key":"ref_5","first-page":"107","article-title":"An analysis of carbenoxolone plasma binding","volume-title":"and clearance in young and elderly people. In Fourth Symposium on Carbenoxolone","author":"Hayes, M.J.; Langman, M.J.S.","year":"1975","unstructured":"Hayes, M. J., and Langman, M. J. S. (1975). An analysis of carbenoxolone plasma binding and clearance in young and elderly people. In Fourth Symposium on Carbenoxolone, pp. 107-114. Edited by F. A. Jones and D. V. Parke. Butterworths: London."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/gut.11.7.555","article-title":"The absorption of carbenoxolone administered orally as a positioned-release capsule","volume":"11","author":"Lindup, W.E.; Parke, D.V.; Colin-Jones, D.","year":"1970","unstructured":"Lindup, W. E., Parke, D. V., and Colin-Jones, D. (1970). The absorption of carbenoxolone administered orally as a positioned-release capsule. Gut, 11, 555-558.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/cs0430393","article-title":"The fate of 14C carbenoxolone in patients with gastric ulcer","volume":"43","author":"Parke, D.V.; Hunt, T.C.; Iveson, P.","year":"1972","unstructured":"Parke, D. V., Hunt, T. C., and Iveson, P. (1972). The fate of 14C carbenoxolone in patients with gastric ulcer. Clinical Science, 43, 393-400.","journal-title":"Clinical Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.2042-7158.1974.tb09199.x","article-title":"A gas chromatographic determination of carbenoxolone in human serum","volume":"26","author":"Rhodes, C.; Wright, P.A.","year":"1974","unstructured":"Rhodes, C., and Wright, P. A. (1974). A gas chromatographic determination of carbenoxolone in human serum. Journal ofPharmacy and Pharmacology, 26, 894-898.","journal-title":"Journal ofPharmacy and Pharmacology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/gut.6.6.591","article-title":"Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects","volume":"6","author":"Turpie, A.G.G.; Thomson, T.J.","year":"1965","unstructured":"Turpie, A. G. G., and Thomson, T. J. (1965). Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut, 6, 591-594.","journal-title":"Gut"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.19.4.330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T10:09:02Z","timestamp":1765620542000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.19.4.330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1978,4,1]]},"published-print":{"date-parts":[[1978,4]]}},"alternative-id":["10.1136\/gut.19.4.330"],"URL":"https:\/\/doi.org\/10.1136\/gut.19.4.330","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1978,4]]}}}