{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:13:03Z","timestamp":1789513983004,"version":"build-2803163510"},"reference-count":14,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p>\n                    The effect on ileostomy function of codeine phosphate, Lomotil, or Isogel was tested in 20 subjects at home living a normal life, studied over two three-day periods on and off treatment. Codeine phosphate 60 mg three times daily was associated with a reduction in the mean total weight of ileostomy output and the ileostomy outputs of water, sodium, and potassium (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b705). The proportion of faecal solids increased on codeine and the effluent appeared thicker but the output of faecal solids remained unchanged. Mean faecal fat increased on codeine. The transit rate from mouth to stoma was slower in four of the five subjects on codeine and a further two subjects withdrew from the trial with temporary intestinal obstruction while on the drug. Lomotil two tablets three times daily was associated with a small and statistically not quite significant fall in the mean total weight of ileostomy output and the ileostomy output of water. Sodium and potassium outputs in the effluent fell on Lomotil (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b705) but the other parameters remained unchanged. Isogel 15 ml three times daily was associated with an increase in the mean total weight of ileostomy output and the ileostomy outputs of water, sodium, potassium, and faecal solids (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b701). Although the effluent looked more viscid on Isogel, the proportion of faecal solids was unchanged. These results suggest that codeine phosphate has a beneficial effect on ileostomy function, reducing the loss of water and electrolytes, while Lomotil has a similar but less effective action in the dosage tested. By contrast, Isogel increases the ileostomy loss of water and electrolytes and will aggravate their depletion in patients with excessive fluid effluents. The increase in faecal fat associated with taking codeine phosphate suggests that it should be stopped before collecting specimens for faecal fat estimations.\n                  <\/jats:p>","DOI":"10.1136\/gut.19.5.377","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"377-383","source":"Crossref","is-referenced-by-count":66,"title":["Effect of codeine phosphate, Lomotil, and Isogel on ileostomy function"],"prefix":"10.1136","volume":"19","author":[{"given":"C. R.","family":"Newton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1978,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/gut.5.1.90","article-title":"Endoradiosonde study of propulsion and pressure activity induced by test meals, Prostigmine and diphenoxylate in the small intestine","volume":"5","author":"Barany, F.; Jacobson, B.","year":"1964","unstructured":"Barany, F., and Jacobson, B. (1964). Endoradiosonde study of propulsion and pressure activity induced by test meals, Prostigmine and diphenoxylate in the small intestine. Gut, 5, 90-95.","journal-title":"Gut"},{"key":"ref_2","first-page":"\"451","article-title":"Clinical studies on the influence of certain drugs in relation to biliary pain and to the variations in intrabiliary pressure","volume":"63","author":"Butsch, W.L.; McGowan, J.M.; Walters, W.","year":"1936","unstructured":"Butsch, W. L., McGowan, J. M., and Walters, W. (1936). Clinical studies on the influence of certain drugs in relation to biliary pain and to the variations in intrabiliary pressure. Surgery, Gynecology, and Obstetrics, 63, 451-456. Gudmand-H0yer, E., and Jarnum, S. (1970). Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn's disease. Gut, 11, 338-343.","journal-title":"Surgery, Gynecology, and Obstetrics; Incidence and clinical significance of lactose malabsorption in ulcerative colitis and Crohn's disease"},{"key":"ref_3","article-title":"Ileostomy: Surgery, Physiology, and Management. Grune and","author":"Hill, G.L.","year":"1976","unstructured":"Hill, G. L. (1976). Ileostomy: Surgery, Physiology, and Management. Grune and Stratton: New York."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/gut.15.12.982","article-title":"Impairment of 'ileostomy adaptation' in patients after ileal resection","volume":"15","author":"Hill, G.L.; Mair, W.S.J.; Goligher, J.C.","year":"1974","unstructured":"Hill, G. L., Mair, W. S. J., and Goligher, J. C. (1974). Impairment of 'ileostomy adaptation' in patients after ileal resection. Gut, 15, 982-987.","journal-title":"Gut"},{"key":"ref_5","first-page":"\"842","article-title":"A new method for studying gut transit times using radioopaque markers","volume":"10","author":"Hinton, J.M.; Lennard-Jones, J.E.; Young, A.C.","year":"1969","unstructured":"Hinton, J. M., Lennard-Jones, J. E., and Young, A. C. (1969). A new method for studying gut transit times using radioopaque markers. Gut, 10, 842-847. van de Kamer, J. H., ten Bokkel Huinink, H., and Weyers, H. A. (1949). Rapid method for the determination of fat in feces. Journal of Biological Chemistry, 177, 347-355.","journal-title":"Gut; Rapid method for the determination of fat in feces"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/gut.4.4.322","article-title":"The composition of ileostomy fluid","volume":"4","author":"Kanaghinis, T.; Lubran, M.; Coghill, N.F.","year":"1963","unstructured":"Kanaghinis, T., Lubran, M., and Coghill, N. F. (1963). The composition of ileostomy fluid. Gut, 4, 322-338.","journal-title":"Gut"},{"key":"ref_7","author":"Macy, I.G.; Hummel, F.C.; Shepherd, M.L.","year":"1943","unstructured":"Macy, I. G., Hummel, F. C., and Shepherd, M. L. (1943)."},{"key":"ref_8","first-page":"195","article-title":"Value of complex carbohydrates in diets of normal children","volume":"65","unstructured":"Value of complex carbohydrates in diets of normal children. American Journal of Diseases in Children, 65, 195-206.","journal-title":"American Journal of Diseases in Children"},{"key":"ref_9","first-page":"855","article-title":"Comparison of bowel function after colectomy and ileostomy or ileorectal anastomosis for inflammatory bowel disease (abstract)","volume":"13","author":"Newton, C.R.","year":"1972","unstructured":"Newton, C. R. (1972). Comparison of bowel function after colectomy and ileostomy or ileorectal anastomosis for inflammatory bowel disease (abstract). Gut, 13, 855.","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02617268","article-title":"The ileostomy: its physical characteristics and chemical behaviour","volume":"6","author":"Nuguid, T.P.; Bacon, H.E.; Boutwell, J.","year":"1963","unstructured":"Nuguid, T. P., Bacon, H. E., and Boutwell, J. (1963). The ileostomy: its physical characteristics and chemical behaviour. 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The effect of cellulose, hemicellulose and lignin on the weight of the stool: a contribution to the study of laxation in man. 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