{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T04:41:09Z","timestamp":1765082469715,"version":"3.46.0"},"reference-count":23,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p>\n                    Eighty three patients were followed-up for four years after an admission to hospital with a chronic gastric ulcer proven by radiology (index ulcer). The index ulcer healed completely in 50 patients, but was unhealed at the time of discharge in the other 33. Significantly fewer patients whose index ulcer was healed compared with those whose ulcer was unhealed at discharge had had a recurrence by one (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b705), two, three and four years' (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b701) follow-up. Moreover, the rate of recurrence was significantly greater for those patients with unhealed, compared with those with a healed index ulcer (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b705) and by the end of the four-year period 61% of patients with unhealed, compared with 26% of those with healed index ulcers had had a recurrence. Patients over the age of 60 years with unhealed index ulcers had a significantly poorer prognosis than those of similar age whose index ulcer was healed at discharge (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b7025). The sex of the ulcer patient did not significantly influence ulcer recurrence. Large ulcers (&gt; 57 mm\n                    <jats:sup>2<\/jats:sup>\n                    ) were less often healed on initial discharge and were more frequently associated with recurrence at one (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b705), two (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b7025), three and four years (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b701) than smaller ulcers ([unk]57 mm\n                    <jats:sup>2<\/jats:sup>\n                    ). Heavy intake of analgesics adversely influenced the course of patients whose ulcer was unhealed (\n                    <jats:sc>p<\/jats:sc>\n                    &lt; 0\u00b705), but did not alter the recurrence rate in those whose ulcer was healed. Ulcer recurrence was not influenced by smoking habits or by alcohol consumption.\n                  <\/jats:p>","DOI":"10.1136\/gut.19.5.419","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"419-424","source":"Crossref","is-referenced-by-count":30,"title":["Effect of ulcer healing on the prognosis of chronic gastric ulcer"],"prefix":"10.1136","volume":"19","author":[{"given":"D. W.","family":"Piper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Shinners","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Greig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila L.","family":"Waller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,5,1]]},"reference":[{"key":"ref_1","first-page":"833","article-title":"Effective treatment of gastric ulceration with a bismuth preparation","volume":"15","author":"Boyes, B.E.; Woolf, I.L.; Wilson, R.Y.; Cowley, D.J.; Dymock, I.W.","year":"1974","unstructured":"Boyes, B. E., Woolf, I. L., Wilson, R. Y., Cowley, D. J., and Dymock, I. W. (1974). Effective treatment of gastric ulceration with a bismuth preparation (De-Nol) (Abstract). Gut, 15, 833.","journal-title":"(De-Nol) (Abstract). Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bjs.1800600704","article-title":"The surgical treatment of peptic ulcer: a 15-year review","volume":"60","author":"Callum, K.G.; Talbot, J.E.","year":"1973","unstructured":"Callum, K. G., and Talbot, J. E. (1973). The surgical treatment of peptic ulcer: a 15-year review. British Journal of Surgery, 60, 511-516.","journal-title":"British Journal of Surgery"},{"key":"ref_3","series-title":"of cimetidine in the treatment of gastric ulcer. In Cimetidine: Proceedings of the Second International Symposium on Histamine H2Receptor Antagonists","first-page":"283","article-title":"A controlled trial","author":"Ciclitira, P.J.; Machell, R.J.; Farthing, M.J.; Dick, A.P.; Hunter, J.","year":"1977","unstructured":"Ciclitira, P. J., Machell, R. J., Farthing, M. J., Dick, A. P., and Hunter, J. (1977). A controlled trial of cimetidine in the treatment of gastric ulcer. In Cimetidine: Proceedings of the Second International Symposium on Histamine H2Receptor Antagonists, pp. 283-286. Edited by W. L. Burland and M. A. Simkins. Excerpta Medica: Amsterdam and Oxford."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/003693306400900501","article-title":"Medical treatment of gastric ulcer","volume":"9","author":"Doll, R.","year":"1964","unstructured":"Doll, R. (1964). Medical treatment of gastric ulcer. Scottish Medical Journal, 9, 183-196.","journal-title":"Scottish Medical Journal"},{"key":"ref_5","first-page":"793","article-title":"Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer","volume":"2","author":"Doll, R.; Hill, I.D.; Hutton, C.; Underwood, II, D.J.","year":"1962","unstructured":"Doll, R., Hill, I. D., Hutton, C., and Underwood, D. J., II. (1962). 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A double blind controlled trial. Personal communication","author":"Landecker, K.D.; Hunt, J.H.; Gillespie, P.; Piper, D.W.","year":"1977","unstructured":"Landecker, K. D., Hunt, J. H., Gillespie, P., and Piper, D. W. (1977). Cimetidine and gastric ulcer healing. A double blind controlled trial. Personal communication."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2165\/00003495-197611040-00001","article-title":"Carbenoxolone sodium: its role in ulcer healing","volume":"11","author":"Langman, M.J.S.","year":"1976","unstructured":"Langman, M. J. S. (1976). Carbenoxolone sodium: its role in ulcer healing. Drugs, 11, 241-244.","journal-title":"Drugs"},{"key":"ref_14","series-title":"Cimetidine: Proceedings of the Second International Symnposium on Histamine H2-Receptor Antagonists","first-page":"287","article-title":"Treatment of gastric ulcer by cimetidine","author":"Burland, W.L.","year":"1977","unstructured":"Multicentre trial (1977). Treatment of gastric ulcer by cimetidine. In Cimetidine: Proceedings of the Second International Symnposium on Histamine H2-Receptor Antagonists, pp. 287-292. Edited by W. L. Burland and M. A. Simkins, Excerpta Medica: Amsterdam and Oxford."},{"key":"ref_15","first-page":"460","article-title":"Gastric ulcer","volume":"139","author":"Nielsen, J.; Amdrup, E.; Christiansen, P.; Fenger, C.; Jensen, H.E.; Lindskov, J.; Nielsen, S.A.D.","year":"1973","unstructured":"Nielsen, J., Amdrup, E., Christiansen, P., Fenger, C., Jensen, H. E., Lindskov, J., and Nielsen, S. A. D. (1973). Gastric ulcer. II. Surgical treatment. Acta Chirurgica Scandinavica, 139, 460-465.","journal-title":"II. Surgical treatment. 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A comparison between a gastroscopically controlled series treated medically and a series treated by surgery","volume":"2","author":"Swynnerton, B.F.; Tanner, N.C.","year":"1953","unstructured":"Swynnerton, B. F., and Tanner, N. C. (1953). Chronic gastric ulcer. A comparison between a gastroscopically controlled series treated medically and a series treated by surgery. British Medical Journal, 2, 841-847.","journal-title":"British Medical Journal"},{"key":"ref_23","article-title":"The incidence of chronic peptic ulcer found at necropsy, A study of 20 000 examinations performed","volume-title":"Leeds in 1930-49 and in England and Scotland in 1956","author":"Watkinson, G.","year":"1960","unstructured":"Watkinson, G. (1960). The incidence of chronic peptic ulcer found at necropsy, A study of 20 000 examinations performed in Leeds in 1930-49 and in England and Scotland in 1956."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.19.5.419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:08:07Z","timestamp":1765076887000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.19.5.419"}},"subtitle":["Four-year follow-up"],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1978,5,1]]},"published-print":{"date-parts":[[1978,5]]}},"alternative-id":["10.1136\/gut.19.5.419"],"URL":"https:\/\/doi.org\/10.1136\/gut.19.5.419","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1978,5]]}}}