{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:19:46Z","timestamp":1765657186146,"version":"3.48.0"},"reference-count":10,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:p>A chronic colitis has been induced in rabbits having many of the histological features of human ulcerative colitis. Animals were first immunised with the common enterobacterial antigen of Kunin and haemagglutinating antibodies demonstrated in high titre. An immune complex colitis was then established by the injection of soluble immune complexes following mild irritation of the rectum with dilute formalin as previously described. The rabbits developed an acute colitis within the first week but, in contrast with unsensitised rabbits, the inflammation persisted and was still present at six months as assessed by proctoscopy and rectal biopsy. Kunin-sensitised rabbits receiving intravenous saline, antigen, or antibody alone did not develop a chronic colitis. It is suggested that hypersensitivity to colonic bacterial antigens may be one mechanism whereby an acute colitis becomes chronic.<\/jats:p>","DOI":"10.1136\/gut.20.1.1","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1-5","source":"Crossref","is-referenced-by-count":56,"title":["Chronic immune colitis in rabbits."],"prefix":"10.1136","volume":"20","author":[{"given":"A S","family":"Mee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H J","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/gut.15.4.294","article-title":"A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease","volume":"15","author":"Bartnik, W.Swarbrick; T., E.; Williams, C.","year":"1974","unstructured":"Bartnik, W. Swarbrick, E. T., and Williams, C. (1974). A study of peripheral leucocyte migration in agarose medium in inflammatory bowel disease. Gut, 15, 294-300.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1084\/jem.93.2.107","article-title":"The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera","volume":"93","author":"Boyden, S.V.","year":"1951","unstructured":"Boyden, S. V. (1951). The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. Journal of Experimental Medicine, 93, 107-120.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0016-5085(73)80090-3","article-title":"Enterobacterial common antigen-induced lymphocyte reactivity in inflammatory bowel disease","volume":"64","author":"Bull, D.M.; lgnaczak, T.F.","year":"1973","unstructured":"Bull, D. M., and lgnaczak, T. F. (1973). Enterobacterial common antigen-induced lymphocyte reactivity in inflammatory bowel disease. Gastroenterology, 64, 43-50.","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/path.1700960113","article-title":"The production of colonic autoantibodies in rabbits by immunisation with Escherichia coli","volume":"96","author":"Cooke, E.M.; Filipe, M.L.; Dawson, I.M.P.","year":"1968","unstructured":"Cooke, E. M., Filipe, M. L., and Dawson, I. M. P. (1968). The production of colonic autoantibodies in rabbits by immunisation with Escherichia coli. Journal of Pathology and Bacteriology, 96, 125-130.","journal-title":"Journal of Pathology and Bacteriology"},{"key":"ref_5","first-page":"187","article-title":"Immune complexes in ulcerative colitis and Crohn's disease","volume":"29","author":"Hodgson, H.J.F.; Potter, B.J.; Jewell, D.P.","year":"1977","unstructured":"Hodgson, H. J. F., Potter, B. J, and Jewell, D P. (1977a). Immune complexes in ulcerative colitis and Crohn's disease. Clinical and Experimental Immunology, 29, 187-196.","journal-title":"Clinical and Experimental Immunology"},{"year":"1977","author":"Hodgson, H.J.F.; Potter, B.J.; Jewell, D.P.","key":"ref_6","unstructured":"Hodgson, H. J. F., Potter, B. J., and Jewell, D. P. (1977b). C}"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.19.3.225","article-title":"Immune-complex mediated colitis in rabbits","volume":"19","unstructured":"Immune-complex mediated colitis in rabbits. Gut, 19, 225-232.","journal-title":"Gut"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.128.6.1339","article-title":"Immunological studies in ulcerative colitis. IV. Origin of autoantibodies","volume":"128","author":"Lagercrantz, R.; Hammarstrom, S.; Perlmann, P.; Gustafsson, B.E.","year":"1968","unstructured":"Lagercrantz, R., Hammarstrom, S., Perlmann, P., and Gustafsson, B. E. (1968). Immunological studies in ulcerative colitis. IV. Origin of autoantibodies. Journal of Experimental Medicine, 128, 1339-1352.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_9","first-page":"249","article-title":"Antibacterial antibodies in rectal and colonic mucosa in ulcerative colitis","volume":"1","author":"Monteiro, E.; Fossey, J.; Shiner, M.; Drasar, B.S.; Allison, A.C.","year":"1971","unstructured":"Monteiro, E., Fossey, J., Shiner, M., Drasar, B. S., and Allison, A. C. (1971). Antibacterial antibodies in rectal and colonic mucosa in ulcerative colitis. Lancet, 1, 249-251.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1749-6632.1965.tb18972.x","article-title":"Antigen from colon of germfree rats and antibodies in human ulcerative colitis","volume":"124","author":"Perlmann, P.; Hammarstrom, S.; Lagercrantz, R.; Gustafsson, B.E.","year":"1965","unstructured":"Perlmann, P., Hammarstrom, S., Lagercrantz, R., and Gustafsson, B. E. (1965). Antigen from colon of germfree rats and antibodies in human ulcerative colitis. Annals of the Newv York Academl of Sciences. 124, 377-394.","journal-title":"Annals of the Newv York Academl of Sciences"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.1.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T20:16:51Z","timestamp":1765657011000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.1.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1979,1,1]]},"published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1136\/gut.20.1.1"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.1.1","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}