{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:56:05Z","timestamp":1779256565426,"version":"3.51.4"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:p>The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.<\/jats:p>","DOI":"10.1136\/gut.20.1.55","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"55-58","source":"Crossref","is-referenced-by-count":15,"title":["Jejunal lysozyme activity and the Paneth cell in coeliac disease."],"prefix":"10.1136","volume":"20","author":[{"given":"M","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Eastwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,1,1]]},"reference":[{"key":"ref_1","first-page":"107","article-title":"Influence of local acidification of tissue bordering cancerous growths","volume":"46","author":"Black, C.E.; Ogle, R.S.","year":"1948","unstructured":"Black, C. 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Serum and urinary lysoxyme (muramidase) in monocytic and monomyeolocytic leukemia. Journal of Experimental Medicine, 124, 921-952.","journal-title":"Journal of Experimental Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/gut.16.7.553","article-title":"The Paneth cell, a source of intestinal lysozyme","volume":"16","author":"Peeters, T.; Van Trappen, G.","year":"1975","unstructured":"Peeters, T., and Van Trappen, G. (1975). The Paneth cell, a source of intestinal lysozyme. Gut, 16, 553-558.","journal-title":"Gut"},{"key":"ref_15","first-page":"594","article-title":"Inactivation of bacteriophage by lysozyme","volume":"18","author":"Ribble, J.C.; Hook, E.W.","year":"1959","unstructured":"Ribble, J. C., and Hook, E. W. (1959). Inactivation of bacteriophage by lysozyme. (Abstract). Federation Proceedings, 18, 594.","journal-title":"(Abstract). 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