{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T11:11:47Z","timestamp":1765624307025,"version":"3.48.0"},"reference-count":32,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,10]]},"abstract":"<jats:p>\n                    To study the effects of acute and chronic cholestasis on vitamin D metabolism we investigated six cases of acute extrahepatic obstructive jaundice and eight cases of primary biliary cirrhosis (PBC) (three supplemented with vitamin D). Plasma 25-hydroxyvitamin D (25OHD) was low in the patients with PBC unsupplemented with vitamin D but normal in obstructive jaundice. None of the patients with PBC showed radiological or histological evidence of osteomalacia. In PBC, dietary intake of vitamin D was low but response to ultra-violet irradiation of the skin was normal even in those with a considerably raised serum bilirubin. Patients with PBC or obstructive jaundice had low levels of 25 hydroxyvitamin D binding protein which correlated with the serum albumin. The half-life of intravenously injected\n                    <jats:sup>3<\/jats:sup>\n                    H vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    (\n                    <jats:sup>3<\/jats:sup>\n                    HD\n                    <jats:sub>3<\/jats:sub>\n                    ) and the subsequent production of\n                    <jats:sup>3<\/jats:sup>\n                    H 25OHD were normal in all the patients with obstructive jaundice and in most with PBC. The two patients with PBC who produced less\n                    <jats:sup>3<\/jats:sup>\n                    H 25OHD than expected were receiving vitamin D supplements. The urinary tritium (\n                    <jats:sup>3<\/jats:sup>\n                    H) excretion after the injection of\n                    <jats:sup>3<\/jats:sup>\n                    HD\n                    <jats:sub>3<\/jats:sub>\n                    correlated with the serum bilirubin. After the injection of\n                    <jats:sup>3<\/jats:sup>\n                    H 25OHD\n                    <jats:sub>3<\/jats:sub>\n                    the urinary excretion of\n                    <jats:sup>3<\/jats:sup>\n                    H was minimal and did not correlate with the serum bilirubin, suggesting that the radioactivity appearing in the urine after the\n                    <jats:sup>3<\/jats:sup>\n                    H vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    injection was associated with vitamin D metabolites other than 25OHD. Factors contributing to the low plasma 25OHD in primary biliary cirrhosis may be a low dietary intake of vitamin D, inadequate exposure to ultra-violet light, and a tendency to urinary wastage of vitamin D metabolites.\n                  <\/jats:p>","DOI":"10.1136\/gut.20.10.840","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"840-847","source":"Crossref","is-referenced-by-count":28,"title":["Vitamin D metabolism in acute and chronic cholestasis"],"prefix":"10.1136","volume":"20","author":[{"given":"R. T.","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Davie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Siklos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. M.","family":"Chalmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. O.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. E. M.","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/gut.15.10.788","article-title":"The relief of bone pain in primary biliary cirrhosis with calcium infusions","volume":"15","author":"Ajdukiewicz, A.B.; Agnew, J.E.; Byers, P.D.; Wills, M.R.; Sherlock, S.","year":"1974","unstructured":"Ajdukiewicz, A. B., Agnew, J. E., Byers, P. D., Wills, M. R., and Sherlock, S. (1974). The relief of bone pain in primary biliary cirrhosis with calcium infusions. Gut, 15, 788-793.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3181\/00379727-149-38853","article-title":"25-hydroxyvitamin D,: evidence of an entero-hepatic circulation in man","volume":"149","author":"Arnaud, S.B.; Goldsmith, R.S.; Lambert, P.W.; Go, V.L.W.","year":"1975","unstructured":"Arnaud, S. B., Goldsmith, R. S., Lambert, P. W., and Go, V. L. W. (1975). 25-hydroxyvitamin D,: evidence of an entero-hepatic circulation in man. Proceedings of the Society for Experimental Biology and Medicine, 149, 570-572.","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"ref_3","first-page":"299","article-title":"Malabsorption and bone disease in prolonged obstructive jaundice","volume":"25","author":"Atkinson, M.; Nordin, B.E.C.; Sherlock, S.","year":"1956","unstructured":"Atkinson, M., Nordin, B. E. C., and Sherlock, S. (1956). Malabsorption and bone disease in prolonged obstructive jaundice. 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Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary biliary cirrhosis. Lancet, 1, 721-724.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S0022-3476(76)81073-6","article-title":"in the management of rickets associated with extrahepatic biliary atresia","volume":"88","author":"Daum, F.; Rosen, J.F.; Roginsky, M.; Cohen, M.I.; Finberg, L.","year":"1976","unstructured":"Daum, F., Rosen, J. F., Roginsky, M., Cohen, M. I., and Finberg, L. (1976).25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia. Journal of Paediatrics, 88, 1041-1043.","journal-title":"Journal of Paediatrics"},{"key":"ref_12","first-page":"231","article-title":"Competitive protein-binding assay for 25 hydroxycholecalciferol","volume":"46","author":"Edelstein, S.; Charman, M.; Lawson, D.E.M.; E, Kodicek","year":"1974","unstructured":"Edelstein, S., Charman, M., Lawson, D. E. M., and Kodicek E. (1974). Competitive protein-binding assay for 25 hydroxycholecalciferol. Clinical Science and Molecular Medicine, 46, 231-240.","journal-title":"Clinical Science and Molecular Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1651-2227.1976.tb04408.x","article-title":"The osteodystrophy of prolonged obstructive liver disease in childhood","volume":"65","author":"Glasgow, J.F.T.; Thomas, P.S.","year":"1976","unstructured":"Glasgow, J. F. T., and Thomas, P. S. (1976). The osteodystrophy of prolonged obstructive liver disease in childhood. Acta Paediatrica Scandinavica, 65, 57-64.","journal-title":"Acta Paediatrica Scandinavica"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/244515a0","article-title":"Natural and synthetic sources of circulating 25-hydroxyvitamin D in man","volume":"244","author":"Haddad, Jr, J.G.; Hahn, T.J.","year":"1973","unstructured":"Haddad, J. G., Jr, and Hahn, T. J. (1973). Natural and synthetic sources of circulating 25-hydroxyvitamin D in man. Nature, 244, 515-517.","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1172\/JCI108575","article-title":"Radioimmunoassay of the binding protein for vitamin D and its metabolites in human serum: concentrations in normal subjects and patients with disorders of mineral homeostasis","volume":"58","author":"Haddad, Jr, J.G.; Walgate, J.","year":"1976","unstructured":"Haddad, J. G., Jr, and Walgate, J. (1976). Radioimmunoassay of the binding protein for vitamin D and its metabolites in human serum: concentrations in normal subjects and patients with disorders of mineral homeostasis. 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R., and Sherlock, S. (1978a). Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease. Gut, 19, 85-90.","journal-title":"Gut"},{"key":"ref_20","first-page":"650","article-title":"Serum 25-hydroxy-vitamin D in untreated parenchymal and cholestatic liver disease","volume":"2","author":"Long, R.G.; Skinner, R.K.; Wills, M.R.; Sherlock, S.","year":"1976","unstructured":"Long, R. G., Skinner, R. K., Wills, M. R., and Sherlock, S. (1976). Serum 25-hydroxy-vitamin D in untreated parenchymal and cholestatic liver disease. Lancet, 2, 650-652.","journal-title":"Lancet"},{"key":"ref_21","article-title":"Formation of vitamin D metabolites from 3H and","author":"Long, R.G.; Skinner, R.K.; Wills, M.R.; Sherlock, S.","year":"1978","unstructured":"Long, R. G., Skinner, R. K., Wills, M. R., and Sherlock, S. (1978b). 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(1979)."},{"key":"ref_25","first-page":"221","article-title":"and 25 hydroxyvitamin D in healthy children and adults","volume":"1","author":"Diet, sunlight","unstructured":"Diet, sunlight, and 25 hydroxyvitamin D in healthy children and adults. British Medical Journal, 1, 221-223.","journal-title":"British Medical Journal"},{"key":"ref_26","first-page":"575","article-title":"Studies of vitamin D deficiency in man","volume":"44","author":"Preece, M.A.; Tomlinson, S.; Ribot, C.A.; Pietrek, J.; Korn, H.T.; Davies, D.M.; Ford, J.A.; Dunnigan, M.G.; O'Riordan, J.L.H.","year":"1975","unstructured":"Preece, M. A., Tomlinson, S., Ribot, C. A., Pietrek, J., Korn, H. T., Davies, D. M., Ford, J. A., Dunnigan, M. G., and O'Riordan, J. L. H. (1975). Studies of vitamin D deficiency in man. 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