{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:37:08Z","timestamp":1765615028041,"version":"3.48.0"},"reference-count":1,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,12]]},"abstract":"<jats:p>Manometric studies of the sigmoid colon were performed on 17 healthy volunteers and on 49 constipated patients, after a long period of fasting (18--20 hours). Motility was recorded using perfused catheters at basal level during 45 minutes, then 60 minutes after a 0.5 mg intravenous injection of neostigmine, and, finally, 30 minutes during and after a meal. Motor activity was assessed by a motility index (per cent of activity x mean amplitude of waves). In both normal and constipated patients, the basal motility index was very low (respectively 82 +\/- 16 and 110 +\/- 113). This low level of activity was due to the long fasting period imposed on all the subjects. After neostigmine the motility index increased in both controls (347 +\/- 256) and constipated patients (311 +\/- 325); this test, however was found to be unreliable. The meal increased the motility index to significantly higher values than after neostigmine in controls (538 +\/- 215). In constipated patients the mean meal motility index was comparable with that of controls (577 +\/- 549) with a large distribution of individual values. Using the mean meal motility index +\/- 2 SD of the control group as a term of comparison, the patients were segregated into three groups: 'hypomotor' patients (eight cases), 'normomotor' patients (33 cases), and 'hypermotor' patients (eight cases). From the evidence of this series of clinically well-defined constipated patients, it was concluded that only the meal test is able to segregate three significant patterns of sigmoid activity and that a large number (68%) of constipated patients exhibit normal sigmoid motor activity.<\/jats:p>","DOI":"10.1136\/gut.20.12.1095","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"1095-1101","source":"Crossref","is-referenced-by-count":37,"title":["Motor activity of the sigmoid colon in chronic constipation: comparative study with normal subjects."],"prefix":"10.1136","volume":"20","author":[{"given":"P","family":"Meunier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rochas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,12,1]]},"reference":[{"key":"ref_1","unstructured":"As in the original study by Chaudary and Truediffered from those in the above-mentioned studies, love (1961), we observed a significant increase of probably accounts for the discordant results that we motility parameters with neostigmine stimulation; observed.","article-title":"As in the original study by Chaudary and Truediffered from those in the above-mentioned studies, love (1961), we observed a significant increase of probably accounts for the discordant results that we motility parameters with neostigmine stimulation; observed"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.12.1095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:33:13Z","timestamp":1765614793000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.12.1095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,12]]},"references-count":1,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1979,12,1]]},"published-print":{"date-parts":[[1979,12]]}},"alternative-id":["10.1136\/gut.20.12.1095"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.12.1095","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1979,12]]}}}