{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:36:30Z","timestamp":1767836190538,"version":"3.49.0"},"reference-count":16,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p>Gynaecomastia has occurred unilaterally or bilaterally in five out of 25 male duodenal ulcer patients after more than four months treatment with cimetidine 1.6 g daily. All elected to continue treatment to 12 months and their breast enlargement regressed rapidly and disappeared after stopping treatment. During treatment all patients were found to have normal concentrations of plasma testosterone and oestradiol, and serum prolactin was normal in the two patients measured. Excision biopsy of the subareolar tissue in one patient revealed histology typical of the florid stage of gynaecomastia. Blockade of androgen-responsive receptors receptors in the target organ appears to be the most likely mechanism involved.<\/jats:p>","DOI":"10.1136\/gut.20.2.154","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"154-157","source":"Crossref","is-referenced-by-count":59,"title":["Gynaecomastia associated with cimetidine."],"prefix":"10.1136","volume":"20","author":[{"given":"R W","family":"Spence","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L R","family":"Celestin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,2,1]]},"reference":[{"key":"ref_1","first-page":"1764","article-title":"Gyn6comastie induite par un inhibiteur de la mono-amine-oxydase","volume":"74","author":"Arroyo, H.","year":"1966","unstructured":"Arroyo, H. (1966). Gyn6comastie induite par un inhibiteur de la mono-amine-oxydase. Presse Mddicale, 74, 1764.","journal-title":"Presse Mddicale"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/ajcp\/57.4.431","article-title":"Gynecomastia: clinico-pathologic study of 351 cases","volume":"57","author":"Bannayan, G.A.; Hajdu, S.I.","year":"1972","unstructured":"Bannayan, G. A., and Hajdu, S. I. (1972). Gynecomastia: clinico-pathologic study of 351 cases. American Journal of Clinical Pathology, 57, 431-437.","journal-title":"American Journal of Clinical Pathology"},{"issue":"247248","key":"ref_3","first-page":"letter.","article-title":"Galactorrhoea with cimetidine","volume":"2","author":"Bateson, M.C.; Browning, M.C.K.; Maconnachie, A.","year":"1977","unstructured":"Bateson, M. C., Browning, M. C. K., and Maconnachie, A. (1977). Galactorrhoea with cimetidine. 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(Letter).","journal-title":"New England Journal of Medicine"},{"key":"ref_8","series-title":"Cimetidine: Proceedings of the Second International Symposium on Histamine H2receptor Antagonists (International Congress Series 416)","first-page":"24","article-title":"A toxicological profile of cimetidine","author":"Leslie, G.B.; Walker, T.F.","year":"1977","unstructured":"Leslie, G. B., and Walker, T. F. (1977). A toxicological profile of cimetidine. In Cimetidine: Proceedings of the Second International Symposium on Histamine H2receptor Antagonists (International Congress Series 416), pp. 24-37. Edited by W. L. Burland and M. A. Simkins. Excerpta Medica: Amsterdam."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1056\/NEJM195302192480802","article-title":"Gynecomastia during digitalis therapy: report of 8 additional cases with liver-function studies","volume":"248","author":"Le Winn, E.B.","year":"1953","unstructured":"Le Winn, E. B. (1953). 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