{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:02:32Z","timestamp":1771642952749,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,2]]},"abstract":"<jats:p>Pancreatic polypeptide (PP) is a newly discovered hormonal peptide localised in a distinct endocrine cell type in the pancreas. PP circulates in plasma and in normal subjects levels rise substantially on the ingestion of food (mean rise 138 pmol\/l). In 10 patients with chronic pancreatitis with exocrine deficiency the PP response to a test breakfast was greatly reduced (mean rise 20 pmol\/l, P less than 0.001). PP response to the meal was normal in 10 patients with active coeliac disease and 12 patients with acute tropical sprue with steatorrhoea.<\/jats:p>","DOI":"10.1136\/gut.20.2.98","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"98-101","source":"Crossref","is-referenced-by-count":49,"title":["Impaired pancreatic polypeptide release in chronic pancreatitis with steatorrhoea."],"prefix":"10.1136","volume":"20","author":[{"given":"T E","family":"Adrian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H S","family":"Besterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C N","family":"Mallinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Garalotis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,2,1]]},"reference":[{"key":"ref_1","first-page":"161","article-title":"Mechanism of pancreatic polypeptide release in man","volume":"1","author":"Adrian, T.E.; Bloom, S.R.; Besterman, H.S.; Barnes, A.J.; Cooke, T.J.C.; Russell, R.C.G.; Faber, R.G.","year":"1977","unstructured":"Adrian, T. E., Bloom, S. R., Besterman, H. S., Barnes, A. J., Cooke, T. J. C., Russell, R. C. G., and Faber, R. G. (1977). Mechanism of pancreatic polypeptide release in man. Lancet, 1, 161-163.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/gut.17.12.940","article-title":"Distribution and release of human pancreatic polypeptide","volume":"17","author":"Adrian, T.E.; Bloom, S.R.; Bryant, M.G.; Polak, J.M.; Heitz, P.; Barnes, A.J.","year":"1976","unstructured":"Adrian, T. E., Bloom, S. R., Bryant, M. G., Polak, J. M., Heitz, P., and Barnes, A. J. (1976). Distribution and release of human pancreatic polypeptide. Gut, 17, 940-944.","journal-title":"Gut"},{"key":"ref_3","first-page":"785","article-title":"Gut hormone profile in coeliac disease","volume":"1","author":"Besterman, H.S.; Bloom, S.R.; Sarson, D.L.; Blackburn, A.M.; Johnston, D.I.; Patel, H.R.; Stewart, J.S.; Modigliani, R.; Guerin, S.; Mallinson, C.N.","year":"1977","unstructured":"Besterman, H. S., Bloom, S. R., Sarson, D. L., Blackburn, A. M., Johnston, D. I., Patel, H. R., Stewart, J. S., Modigliani, R., Guerin, S., and Mallinson, C. N. (1977). Gut hormone profile in coeliac disease Lancet. 1, 785-788.","journal-title":"Lancet"},{"key":"ref_4","first-page":"812","article-title":"Failure of secretin release in coeliac disease","volume":"17","author":"Bloom, S.R.; Patel, H.R.; Johnston, D.I.","year":"1976","unstructured":"Bloom, S. R., Patel, H. R., and Johnston, D. I. (1976). Failure of secretin release in coeliac disease. (Abstract). Gut, 17, 812.","journal-title":"(Abstract). Gut"},{"key":"ref_5","first-page":"318","volume-title":"Hormonal contaminants of insulin. In Gut Hormones","author":"Bloom, S.R.; West, A.M.; Polak, J.M.; Barnes, A.J.; Adrian, T.E.","year":"1978","unstructured":"Bloom, S. R., West, A. M., Polak, J. M., Barnes, A. J., and Adrian, T. E. (1978). Hormonal contaminants of insulin. In Gut Hormones, pp. 318-322. Edited by S. R. Bloom. Churchill Livingstone: Edinburgh."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00422096","article-title":"Gastric inhibitory polypeptide (GIP), gastrin and insulin: response to test meal in coeliac disease and after duodeno-pancreatectomy","volume":"12","author":"Creutzfeldt, W.; Ebert, R.; Arnold, R.; Frerichs, H.; Brown, J.C.","year":"1976","unstructured":"Creutzfeldt, W., Ebert, R., Arnold, R., Frerichs, H., and Brown, J. C. (1976). Gastric inhibitory polypeptide (GIP), gastrin and insulin: response to test meal in coeliac disease and after duodeno-pancreatectomy. Diabetologia, 12, 279-286.","journal-title":"Diabetologia"},{"key":"ref_7","first-page":"1149","article-title":"Pancreozymin secretion is impaired in sprue","volume":"56","author":"DiMagno, E.P.; Go, V.L.W.; Summerskill, W.H.J.","year":"1969","unstructured":"DiMagno, E. P., Go, V. L. W., and Summerskill, W. H. J. (1969). Pancreozymin secretion is impaired in sprue. (Abstract). Gastroenterology, 56, 1149.","journal-title":"(Abstract). Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1056\/NEJM197304192881603","article-title":"Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency","volume":"288","author":"DiMagno, E.P.; Go, V.L.W.; Summerskill, W.H.J.","year":"1973","unstructured":"DiMagno, E. P., Go, V. L. W., and Summerskill, W. H. J. (1973). Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. New England Journal of Medicine, 288, 813-815.","journal-title":"New England Journal of Medicine"},{"key":"ref_9","first-page":"146","article-title":"Regulation in healthy subjects of the secretion of human pancreatic polypeptide, a newly recognised pancreatic islet polypeptide","volume":"89","author":"Floyd, Jr., J.C.; Fajans, S.S.; Pek, S.","year":"1976","unstructured":"Floyd, J. C., Jr., Fajans, S. S., and Pek, S. (1976). Regulation in healthy subjects of the secretion of human pancreatic polypeptide, a newly recognised pancreatic islet polypeptide. Transaction of the Association of American Physicians, 89, 146-158.","journal-title":"Transaction of the Association of American Physicians"},{"issue":"49","key":"ref_10","first-page":"68","article-title":"Investigation of a physiological role for pancreatic polypeptide (PP) in man","volume":"13","year":"1978","unstructured":"Greenberg, G. R., McCloy, R. F., Bjdrnsson, 0. G., Adrian, T. E., Chadwick, V. S., Baron, J. H., and Bloom, S. R. (1978). Investigation of a physiological role for pancreatic polypeptide (PP) in man. Scandinavian Journal of Gastroenterology, 13, (Suppl. 49), 68.","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diab.23.4.257","article-title":"Glucagon responses to arginine in chronic pancreatitis","volume":"23","author":"Kalk, W.J.; Vinik, A.I.; Bank, S.; Buchanan, K.D.; Keller, P.; Jackson, W.P.U.","year":"1974","unstructured":"Kalk, W. J., Vinik, A. I., Bank, S., Buchanan, K. D., Keller, P., and Jackson, W. P. U. (1974). Glucagon responses to arginine in chronic pancreatitis. Diabetes, 23, 257-263.","journal-title":"Diabetes"},{"key":"ref_12","author":"Larsson, L.I.; Sundler, F.; Hakanson, R.","year":"1976","unstructured":"Larsson, L. I., Sundler, F., and Hakanson, R. 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Lancet, 1, 328-330.","journal-title":"Lancet"},{"key":"ref_15","first-page":"1102","article-title":"Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy","volume":"1","author":"Schwartz, T.W.; Rehfeld, J.F.; Stadil, F.; Larsson, L.-I.; Chance, R.E.; Moon, N.","year":"1976","unstructured":"Schwartz, T. W., Rehfeld, J. F., Stadil, F., Larsson, L.-I., Chance, R. E., and Moon, N. (1976). Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet, 1, 1102-1105.","journal-title":"Lancet"},{"key":"ref_16","first-page":"864","article-title":"Coeliac sprue disease","volume-title":"Gastrointestinal Disease, Pathophysiology, Diagnosis, Management","author":"Trier, J.S.","year":"1973","unstructured":"Trier, J. S. (1973). Coeliac sprue disease. In Gastrointestinal Disease, Pathophysiology, Diagnosis, Management, pp. 864-885. Edited by M. H. Sleisenger and J. S. Fordtran. 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Scandinavian Journal of Gastroenterology, 2, 81-89.","journal-title":"Scandinavian Journal of Gastroenterology; pH and concentration of pancreatic enzymes in aspirates from the human duodenum during digestion of a standard meal in patients with intestinal disorders"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.2.98","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:24:34Z","timestamp":1765635874000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.2.98"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,2]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1979,2,1]]},"published-print":{"date-parts":[[1979,2]]}},"alternative-id":["10.1136\/gut.20.2.98"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.2.98","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,2]]}}}