{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:56:56Z","timestamp":1765616216544,"version":"3.48.0"},"reference-count":9,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,4]]},"abstract":"<jats:p>An accurate morphometric method is described for quantifying the intraepithelial lymphocytes (IEL), the area of the epithelium, and the volume of the lamina propria in jejunal mucosa of coeliac patients. All measurements are related to a unit-length of muscularis mucosa which is unaltered by the disease process. The results show a significant decrease in the epithelial surface area and an increase in the volume of the lamina propria in coeliac jejunal mucosa compared with normal levels, even after treatment. The number of IEL is the same as normal before or after treatment. Other workers have shown an apparent increase in IEL in untreated disease which returns to normal levels after therapy. This discordance is explained and the importance of accurate quantitative methodology is stressed.<\/jats:p>","DOI":"10.1136\/gut.20.4.275","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"275-278","source":"Crossref","is-referenced-by-count":38,"title":["Measuring intraepithelial lymphocytes, surface area, and volume of lamina propria in the jejunal mucosa of coeliac patients."],"prefix":"10.1136","volume":"20","author":[{"given":"M","family":"Guix","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,4,1]]},"reference":[{"key":"ref_1","volume-title":"Quantitative methods in histology. In Recent Advances in Clinical Pathology, pp.401-416. Series 5","author":"Dunnill, M.S.","year":"1968","unstructured":"Dunnill, M. S. (1968). Quantitative methods in histology. In Recent Advances in Clinical Pathology, pp.401-416. Series 5. Edited by S. C. Dyke, Churchill: London."},{"key":"ref_2","article-title":"Lymphocytes in Coeliac disease","author":"Ferguson, A.","year":"1974","unstructured":"Ferguson, A. (1974). Lymphocytes in Coeliac disease. In Coeliac Disease, pp.265-276. Edited by W. I. J. M. Hekkens and A. S. Pena. Sternfert-Kroese: Leyden."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1136\/gut.18.11.921","article-title":"Intraepithelial lymphocytes of the small intestine","volume":"18","author":"Ferguson, A.","year":"1977","unstructured":"Ferguson, A. (1977). Intraepithelial lymphocytes of the small intestine. Gut, 18, 921-937.","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/gut.12.12.988","article-title":"Quantitation of intraepithelial lymphocytes in human jejunum","volume":"12","author":"Ferguson, A.; Murray, D.","year":"1971","unstructured":"Ferguson, A., and Murray, D. (1971). Quantitation of intraepithelial lymphocytes in human jejunum. Gut, 12, 988-994.","journal-title":"Gut"},{"key":"ref_5","article-title":"Ultrastructural analysis of plasma cells in coeliac patients","author":"Guix, M.; Skinner, J.M.; Whitehead, R.","year":"1978","unstructured":"Guix, M., Skinner, J. M., and Whitehead, R. (1978). Ultrastructural analysis of plasma cells in coeliac patients. (Submitted to Gut.)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/gut.15.4.278","article-title":"Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal","volume":"15","author":"Holmes, G.K.T.; Asquith, P.; Stokes, P.L.; W., Cooke; T.","year":"1974","unstructured":"Holmes, G. K. T., Asquith, P., Stokes, P. L., and Cooke W., T. (1974). Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal. Gut, 15, 278-283.","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/jcp.29.7.587","article-title":"Cellular infiltrate of the jejumun after reintroduction of dietary gluten in children with treated coeliac disease","volume":"29","author":"Lancaster-Smith, M.; Packer, S.; Kumar, P.J.; Harries, J.T.","year":"1976","unstructured":"Lancaster-Smith, M., Packer, S., Kumar, P. J., and Harries, J. T. (1976). Cellular infiltrate of the jejumun after reintroduction of dietary gluten in children with treated coeliac disease. Journal of Clinical Pathology, 29, 587-591.","journal-title":"Journal of Clinical Pathology"},{"key":"ref_8","article-title":"Statistical Package for Social Sciences","author":"Nie, N.H.; Hadlei Hull, C.; Jenkins, J.G.; Steinbrenner, K.; Bent, D.H.","year":"1975","unstructured":"Nie, N. H., Hadlei Hull, C., Jenkins, J. G., Steinbrenner, K., and Bent, D. H. (1975). Statistical Package for Social Sciences. 2nd Edition. McGraw-Hill: London.","edition":"2nd Edition"},{"key":"ref_9","first-page":"81","article-title":"The intraepithelial lymphocytes of the intestinum. Morphological observations and immunologic aspects of intestinal enteropathy","volume":"57","author":"Otto, H.F.","year":"1973","unstructured":"Otto, H. F. (1973). The intraepithelial lymphocytes of the intestinum. Morphological observations and immunologic aspects of intestinal enteropathy. Current Topics in Pathology, 57, 81-121.","journal-title":"Current Topics in Pathology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.4.275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T08:52:46Z","timestamp":1765615966000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.4.275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1979,4,1]]},"published-print":{"date-parts":[[1979,4]]}},"alternative-id":["10.1136\/gut.20.4.275"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.4.275","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1979,4]]}}}