{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T07:25:16Z","timestamp":1777188316216,"version":"3.51.4"},"reference-count":27,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,5]]},"abstract":"<jats:p>Estimates were made of the arsenic concentration in liver specimens from nine patients having idiopathic portal hypertension (IP), and in four livers these were found to be significantly higher than those in patients with cirrhosis and in control subjects. The splenovenogram revealed extensive portosystemic collateral circulation. Corrected sinusoidal pressure and blood flow studies showed higher levels in four patients than in normal subjects. Microscopic examination of liver tissues revealed periportal fibrosis. The higher hepatic arsenic levels that were found were due to the inadvertent drinking of water contaminated with arsenic, adulterated opium, and indigenous medicines. A history of opium intake was not forthcoming but two patients had drunk water contaminated with arsenic and two others had taken bhasams (Ayurvedic medicines prepared by repeated oxidation of ores). Though the aetiology of idiopathic portal hypertension is not known, it is possible that arsenic intake may be one of the factors.<\/jats:p>","DOI":"10.1136\/gut.20.5.378","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"378-384","source":"Crossref","is-referenced-by-count":86,"title":["Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis) in India."],"prefix":"10.1136","volume":"20","author":[{"given":"D V","family":"Datta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P N","family":"Chhuttani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R N","family":"Chakravarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,5,1]]},"reference":[{"key":"ref_1","first-page":"351","article-title":"The presence of high levels of arsenic in the liver biopsy specimens of patients with idiopathic portal hypertension raises important questions. It is possible that arsenic plays a part in the pathogenesis of this disorder","volume":"55","author":"Mallik, K.C.Sen Gupta; P., K.; Basu, A.K.; Biswas, S.K.; Pal, N.C.; Boyer, J.","year":"1967","unstructured":"The presence of high levels of arsenic in the liver biopsy specimens of patients with idiopathic portal hypertension raises important questions. It is possible that arsenic plays a part in the pathogenesis of this disorder. However, with the data that are available Basu Mallik, K. C.. Sen Gupta, K. P., Basu, A. K., Biswas, S. K., Pal, N. C., and Boyer, J. (1967). Non-cirrhotic portal fibrosis with portal hypertension: a new syndrome. Indian Journal of Medical Research, 55, 351-359.","journal-title":"Indian Journal of Medical Research; Non-cirrhotic portal fibrosis with portal hypertension: a new syndrome"},{"key":"ref_2","first-page":"41","article-title":"at present, it is not possible to determine whether or not arsenic plays a similar role in the pathogenesis of cryptogenic cirrhosis. From the epidemiological point of view, it is important and establishes the Basu Mallik","volume":"66","author":"Boyer, J.L.; Sen Gupta, K.P.; Biswas, S.K.; Pal, N.C.","year":"1967","unstructured":"Boyer, J. L., Sen Gupta, K. P., Biswas, S. K., Pal, N. C., at present, it is not possible to determine whether or not arsenic plays a similar role in the pathogenesis of cryptogenic cirrhosis. From the epidemiological point of view, it is important and establishes the Basu Mallik, K. C., lber, F. L., and Basu, A. K. (1967). Idiopathic portal hypertension. Annals of Internal Medicine, 66, 41-68.","journal-title":"Annals of Internal Medicine; Idiopathic portal hypertension"},{"key":"ref_3","first-page":"43","article-title":"The use of Indocyanine green in the source of arsenic. We have already shown that measurement of hepatic blood flow and as a test of hepatic opium, bhasams, and the village water supply are important souices of arsenic intake in northern function","volume":"21","author":"Caesar, J.; Shaldon, S.; Chiandussi, L.; Guevara, L.; Sherlock, S.","year":"1961","unstructured":"Caesar, J., Shaldon, S., Chiandussi, L., Guevara, L., and Sherlock, S. (1961). The use of Indocyanine green in the source of arsenic. We have already shown that measurement of hepatic blood flow and as a test of hepatic opium, bhasams, and the village water supply are important souices of arsenic intake in northern function. Clinical Science, 21, 43-57.","journal-title":"Clinical Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1212\/WNL.17.3.269","volume":"17","author":"Chhuttani, P.N.; Chawla, L.S.; Sharma, T.D.","year":"1967","unstructured":"Chhuttani, P. N., Chawla, L. S., and Sharma, T. D. (1967). Arsenical neuropathy. Neurology, 17, 269-274.","journal-title":"Arsenical neuropathy. Neurology"},{"key":"ref_5","article-title":"At present we are engaged in a large scale","volume-title":"Tropical Gastroenterology","author":"India","year":"1975","unstructured":"India. At present we are engaged in a large scale Datta, D. V. (1975). Tropical Gastroenterology. Edited by"},{"key":"ref_6","first-page":"511","article-title":"Non-cirrhotic portal fibrosis ('Idiopathic' portal hypertension in India)","volume":"24","author":"Datta, D.V.","year":"1976","unstructured":"Datta, D. V. (1976a). Non-cirrhotic portal fibrosis ('Idiopathic' portal hypertension in India). 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American Journal of Medicine, 61, 459-464.","journal-title":"American Journal of Medicine"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.5.378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:39:43Z","timestamp":1765010383000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.5.378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,5]]},"references-count":27,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1979,5,1]]},"published-print":{"date-parts":[[1979,5]]}},"alternative-id":["10.1136\/gut.20.5.378"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.5.378","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,5]]}}}