{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:37:18Z","timestamp":1791121038142,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:p>Collagenisation of the space of Disse was systematically assessed to determine its relationship to the clinical and histological manifestations of chronic alcoholic liver disease. Ninety-four chronic alcoholics who had been submitted to biopsy were assessed by clinical manifestations of hepatic dysfunction and by a 17-parameter Combined Clinical and Laboratory Index (CCLI). Liver biopsies were scored for light (LM) and electron-microscopy (EM) abnormalities using a universal scoring system for both. Thirty-five patients with normal liver histology (LM) had an average collagen score of 0.6 +\/- 0.1. Twelve cirrhotic patients and 29 with fatty liver, both groups with mild clinical manifestations, did not differ significantly. In 18 cirrhotic patients and five with fatty liver, both groups having severe clinical manifestations, the mean scores were 2.1 +\/- 0.8 (P less than 0.02) and 2.5 +\/- 0.6 (P less than 0.01) respectively. Collagenisation also correlated with CCLI (P less than 0.001), serum bilirubin (P less than 0.001), serum aspartate transferase (SGOT) (P less than 0.003), and clinical evidence of portal hypertension and histological changes of necrosis, inflammation, and terminal hepatic vein sclerosis. These results suggest that collagenisation of the Disse space may be important in the pathogenesis of alcoholic liver disease.<\/jats:p>","DOI":"10.1136\/gut.20.8.673","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"673-679","source":"Crossref","is-referenced-by-count":110,"title":["Collagenisation of the Disse space in alcoholic liver disease."],"prefix":"10.1136","volume":"20","author":[{"given":"H","family":"Orrego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Medline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Blendis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Kreaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1979,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.7326\/0003-4819-66-1-41","article-title":"Idiopathic portal hypertension: Comparison with the portal hypertension of cirrhosis and extrahepatic portal vein obstruction","volume":"66","author":"Boyer, J.L.; Sen Gupta, K.P.; Biswas, S.K.; Pal, N.C.; Basu Mallick, K.C.; Iber, F.L.; Basu, A.K.","year":"1967","unstructured":"Boyer, J. L., Sen Gupta, K. P., Biswas, S. K., Pal, N. C., Basu Mallick, K. C., Iber, F. L., and Basu, A. K. (1967). Idiopathic portal hypertension: Comparison with the portal hypertension of cirrhosis and extrahepatic portal vein obstruction. Annals of Internal Medicine, 66, 41-68.","journal-title":"Annals of Internal Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00005792-196703000-00006","article-title":"The early stage of liver injury in the alcoholic","volume":"46","author":"Edmondson, H.A.; Peters, R.L.; Frankel, H.H.; Borowsky, S.","year":"1967","unstructured":"Edmondson, H. A., Peters, R. L., Frankel, H. H., and Borowsky, S. (1967). The early stage of liver injury in the alcoholic. Medicine Baltimore, 46, 119-129.","journal-title":"Medicine Baltimore"},{"key":"ref_3","article-title":"Alcohol-induced susceptibility to hypoxic damage: Possible role in the pathogenesis of alcoholic liver disease","volume-title":"Alcohol and the","author":"Israel, Y.; Orrego, H.; Khanna, J.M.; Stewart, D.J.; Phillips, M.J.; Kalant, H.","year":"1977","unstructured":"Israel, Y., Orrego, H., Khanna, J. M., Stewart, D. J., Phillips, M. J., and Kalant, H. (1977). Alcohol-induced susceptibility to hypoxic damage: Possible role in the pathogenesis of alcoholic liver disease. In Alcohol and the"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0016-5085(19)31793-7","article-title":"Current concepts of liver structure as related to function","volume":"73","author":"Rankin","year":"1977","unstructured":"Rankin. Plenum Press: New York. Jones, A. L., and Schmucker, D. L. (1977). Current concepts of liver structure as related to function. Gastroenterology, 73, 833-851.","journal-title":"Gastroenterology"},{"key":"ref_5","author":"Kluge, T.; Sommerschild, H.; Flatmark, A.","year":"1970","unstructured":"Kluge, T., Sommerschild, H., and Flatmark, A. (1970)."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0016-5085(19)32475-8","article-title":"Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis","volume":"69","author":"Layden, T.J.; Schwarz, J.; Boyer, J.L.","year":"1975","unstructured":"Layden, T. J., Schwarz, J., and Boyer, J. L. (1975). Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis. Gastroenterology, 69, 724-738.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"405","article-title":"Histologic fixatives suitable for diagnostic light and electron microscopy","volume":"100","author":"MacDowell, E.M.; Trump, B.F.","year":"1976","unstructured":"MacDowell, E. M., and Trump, B. F. (1976). Histologic fixatives suitable for diagnostic light and electron microscopy. Archives of Pathology and Laboratory Medicine, 100, 405-414.","journal-title":"Archives of Pathology and Laboratory Medicine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0016-5085(79)80136-5","article-title":"Effect of short-term therapy with propylthiouracil in patients with alcoholic liver disease","volume":"76","author":"Orrego, H.; Kalant, H.; Israel, Y.; Blake, J.E.; Medline, A.; Rankin, J.G.; Armstrong, A.; Kapur, B.M.","year":"1979","unstructured":"Orrego, H., Kalant, H., Israel, Y., Blake, J. E., Medline, A., Rankin, J. G., Armstrong, A., and Kapur, B. M. (1979). Effect of short-term therapy with propylthiouracil in patients with alcoholic liver disease. Gastroenterology, 76, 105-111.","journal-title":"Gastroenterology"},{"key":"ref_9","first-page":"985","article-title":"Electron microscopy of liver cells in cirrhotic nodules. I: The lateral cell membranes","volume":"46","author":"Phillips, M.J.; Steiner, J.W.","year":"1965","unstructured":"Phillips, M. J., and Steiner, J. W. (1965). Electron microscopy of liver cells in cirrhotic nodules. I: The lateral cell membranes. American Journal of Pathology, 46, 985-1005.","journal-title":"American Journal of Pathology"},{"key":"ref_10","first-page":"265","article-title":"Studies on hepatic fibrosis","volume":"10","author":"Popper, H.; Paronetto, F.; Schaffner, F.; Perez, V.","year":"1961","unstructured":"Popper, H., Paronetto, F., Schaffner, F., and Perez, V. (1961). Studies on hepatic fibrosis. Laboratory Investigation, 10, 265-290.","journal-title":"Laboratory Investigation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1530-0277.1978.tb04738.x","article-title":"Alcoholic liver disease: the problems of diagnosis","volume":"2","author":"Rankin, J.G.D.; Orrego, H.; Deschenes, J.; Medline, A.; Findlay, J.E.; Armstrong, A.I.M.","year":"1978","unstructured":"Rankin, J. G. D., Orrego, H., Deschenes, J., Medline, A., Findlay, J. E., and Armstrong, A. I. M. (1978). Alcoholic liver disease: the problems of diagnosis. AlcoholismClinical and Experimental Research, 2, 327-338.","journal-title":"AlcoholismClinical and Experimental Research"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0026-2862(73)90021-6","article-title":"The microcirculatory hepatic unit","volume":"6","author":"Rappaport, A.M.","year":"1973","unstructured":"Rappaport, A. M. (1973). The microcirculatory hepatic unit. Microvascular Research, 6, 212-228.","journal-title":"Microvascular Research"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7326\/0003-4819-70-3-497","article-title":"Portal hypertension without cirrhosis in alcoholic liver disease","volume":"70","author":"Reynolds, T.B.; Hildemura, R.; Michel, H.; Peters, R.","year":"1969","unstructured":"Reynolds, T. B., Hildemura, R., Michel, H., and Peters, R. (1969). Portal hypertension without cirrhosis in alcoholic liver disease. Annals of Internal Medicine, 70, 497-506.","journal-title":"Annals of Internal Medicine"},{"key":"ref_14","first-page":"161","article-title":"Non-cirrhotic portal fibrosis","volume":"51","author":"Sama, S.K.; Bhargava, S.; Nath, N.G.; Talwar, J.R.; Nayak, N.C.; Tandon, B.N.; Wig, K.L.","year":"1971","unstructured":"Sama, S. K., Bhargava, S., Nath, N. G., Talwar, J. R., Nayak, N. C., Tandon, B. N., and Wig, K. L. (1971). Non-cirrhotic portal fibrosis. American Journal ofMedicine, 51, 161-169.","journal-title":"American Journal ofMedicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0016-5085(63)80130-4","article-title":"Capillarization of hepatic sinusoids in man","volume":"44","author":"Schaffner, F.; Popper, H.","year":"1963","unstructured":"Schaffner, F., and Popper, H. (1963). Capillarization of hepatic sinusoids in man. Gastroenterology, 44, 239-242.","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1136\/gut.11.3.275","article-title":"Liver biopsy in the diagnosis of cirrhosis","volume":"11","author":"Scheuer, P.J.","year":"1970","unstructured":"Scheuer, P. J. (1970). Liver biopsy in the diagnosis of cirrhosis. Gut, 11, 275-278.","journal-title":"Gut"},{"key":"ref_17","first-page":"39","article-title":"Ultrastructure of hepatic fibrosis and fat-storing cells","volume-title":"Collagen Metabolism in the Liver","author":"Tanikawa, K.","year":"1975","unstructured":"Tanikawa, K. (1975). Ultrastructure of hepatic fibrosis and fat-storing cells. In Collagen Metabolism in the Liver, pp. 39-99. Edited by H. Popper and K. Becker. Stratton Intercontinental Medical Book Corporation: New York."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.8.673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T17:02:44Z","timestamp":1765645364000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.8.673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1979,8,1]]},"published-print":{"date-parts":[[1979,8]]}},"alternative-id":["10.1136\/gut.20.8.673"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.8.673","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,8]]}}}