{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:22:37Z","timestamp":1764994957858,"version":"3.46.0"},"reference-count":26,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:p>Twelve non-obese patients with radiolucent gallstones were fed on a standard diet. After 10 days (period A), six patients received 15 mg\/kg\/day of ursodeoxycholic acid (UDCA) (group I) and the other six (group II) the same dose of chenodeoxycholic acid (CDCA) for 15 days (period B). An intravenous injection of 20 micro Ci of 14C-UDCA and of 14C-CDCA was given on the 11th day of period B to the patients of group I and II respectively. Stools were collected at the end of period A and B and one bile sample was collected on the 12th day of period B. The faecal bile acid loss was higher during chenotherapy (36.12 mumol\/kg\/day) than during ursotherapy (23.94 mumol\/kg\/day), as was the proportion of lithocholic acid (73% vs 43%) in the faeces. Decay constant rate of faecal radioactivity was 0.365 day-1 in group I and 0.642 in group II. The results indicate that faecal bile acid excretion and turnover rate are greater during CDCA than UDCA, while UDCA increases the bile acid pool size to an even greater extent than does CDCA (150.2 vs 94.9 mumol\/kg). This is probably because the former is more slowly degraded to poorly reabsorbable compounds. In fact, the bile saturation index was 0.66 in group I and 1.05 in group II, even though biliary CDCA in the latter had risen to 69.6%.<\/jats:p>","DOI":"10.1136\/gut.20.8.698","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"698-704","source":"Crossref","is-referenced-by-count":30,"title":["Faecal bile acid loss and bile acid pool size during short-term treatment with ursodeoxycholic and chenodeoxycholic acid in patients with radiolucent gallstones."],"prefix":"10.1136","volume":"20","author":[{"given":"G","family":"Salvioli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Salati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/gut.17.6.405","article-title":"Lithocholate metabolism during chenotherapy for gallstone dissolution. 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Metabolism of lithocholate in healthy man."},{"key":"ref_7","first-page":"\"67","article-title":"Effect of oral chenodeoxycholic acid on bile acid kinetics and biliary lipid composition in women with cholelithiasis","volume":"69","author":"circulation, Enterohepatic","year":"1973","unstructured":"Enterohepatic circulation. Gastroenterology, 69, 67-76. Danzinger, R. G., Hofmann, A. F., Thistle, J. L., and Schoenfield, L. J. (1973). Effect of oral chenodeoxycholic acid on bile acid kinetics and biliary lipid composition in women with cholelithiasis. Journal of Clinical Investigation, 52, 2809-2821.","journal-title":"Gastroenterology"},{"key":"ref_8","first-page":"127","article-title":"Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function","volume":"47","author":"Davignon, J.; Simmonds, W.J.; Ahrens, E.H.","year":"1968","unstructured":"Davignon, J., Simmonds, W. J., and Ahrens, E. H. Jr (1968). 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Journal of Lipid Research, 16, 155-158.","journal-title":"Journal of Lipid Research"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1432-1033.1976.tb10576.x","article-title":"Sulfated bile acids in germ-free and conventional mice","volume":"66","author":"Eyssen, H.J.; Parmentier, G.G.; Mertens, J.A.","year":"1976","unstructured":"Eyssen, H. J., Parmentier, G. G., and Mertens, J. A. (1976). Sulfated bile acids in germ-free and conventional mice. European Journal of Biochemistry, 66, 507-514.","journal-title":"European Journal of Biochemistry"},{"key":"ref_11","first-page":"1220","article-title":"Formation of lithocholic acid from chenodeoxycholic acid and ursodeoxycholic acid by intestinal bacteria","volume":"73","author":"Federowski, T.; Salen, G.; Mosbach, E.H.","year":"1977","unstructured":"Federowski, T., Salen, G., and Mosbach, E. H. (1977a). 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Changes in biliary lipid and biliary bile acid composition in patients after administration of ursodeoxycholic acid. Journal of Lipid Research, 19, 723-728.","journal-title":"Journal of Lipid Research"},{"key":"ref_17","first-page":"690","article-title":"Dissolution of cholesterol gallstones by long-term administration of ursodeoxycholic acid","volume":"72","author":"Makino, I.; Shinozaki, K.; Yoshino, K.; Nakagawa, S.","year":"1975","unstructured":"Makino, I., Shinozaki, K., Yoshino, K., and Nakagawa, S. (1975). Dissolution of cholesterol gallstones by long-term administration of ursodeoxycholic acid. Japanese Journal of Gastroenterology, 72, 690-702.","journal-title":"Japanese Journal of Gastroenterology"},{"key":"ref_18","first-page":"1297","article-title":"Ursodeoxycholic acid treatment of gallstones. Doseresponse study and possible mechanism of action","volume":"2","author":"Maton, P.N.; Murphy, G.M.; Dowling, R.H.","year":"1977","unstructured":"Maton, P. N., Murphy, G. M., and Dowling, R. H. (1977). Ursodeoxycholic acid treatment of gallstones. Doseresponse study and possible mechanism of action. Lancet, 2, 1297-1301.","journal-title":"Lancet"},{"key":"ref_19","first-page":"261","article-title":"Bile salt malabsorption in regional ileitis, ileal resection, and mannitolinduced diarrhea","volume":"47","author":"Meihoff, W.E.; Kern, F.","year":"1968","unstructured":"Meihoff, W. E., and Kern, F. Jr (1968). Bile salt malabsorption in regional ileitis, ileal resection, and mannitolinduced diarrhea. Journal of Clinical Investigation, 47, 261-267.","journal-title":"Jr"},{"key":"ref_20","first-page":"253","article-title":"Metabolism of bile acids. V. Metabolism of ursodeoxycholic acid in Rhesus monkey","volume":"26","author":"Ota, M.; Matsumoto, N.; Kuramoto, T.; Hoshita, T.","year":"1977","unstructured":"Ota, M., Matsumoto, N., Kuramoto, T., and Hoshita, T. (1977). Metabolism of bile acids. V. Metabolism of ursodeoxycholic acid in Rhesus monkey. Hiroshima Journal of Medical Sciences, 26, 253-262.","journal-title":"Hiroshima Journal of Medical Sciences"},{"key":"ref_21","first-page":"32","article-title":"Sulphated faecal bile acid excretion-an underestimated factor (Abstract)","volume":"54","author":"Podesta, M.T.; Murphy, G.M.; Sladen, G.E.; Dowling, R.H.","year":"1978","unstructured":"Podesta, M. T., Murphy, G. M., Sladen, G. E., and Dowling, R. H. (1978). Sulphated faecal bile acid excretion-an underestimated factor (Abstract). Clinical Science and Molecular Medicine, 54, 32 P.","journal-title":"Clinical Science and Molecular Medicine"},{"key":"ref_22","first-page":"345","article-title":"Changes induced by ursodeoxycholic acid (UDCA) on the lipid composition of bile and plasma of subjects with cholesterol gallstone (CG). 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Journal of Laboratory and Clinical Medicine, 70, 627-639.","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0022-2275(20)36852-8","article-title":"Hyocholic acid as internal standard for quantitation of human fecal bile acids","volume":"14","author":"Subbiah, M.T.R.","year":"1973","unstructured":"Subbiah, M. T. R. (1973). Hyocholic acid as internal standard for quantitation of human fecal bile acids. Journal of Lipid Research, 14, 692-694.","journal-title":"Journal of Lipid Research"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0016-5085(19)33056-2","article-title":"A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates","volume":"65","author":"Thomas, P.J.; Hofmann, A.F.","year":"1973","unstructured":"Thomas, P. J., and Hofmann, A. F. (1973). 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