{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:41:55Z","timestamp":1757706115321,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,8]]},"abstract":"<jats:p>Sixty patients with gastric ulcers were treated for four weeks with either 1 g cimetidine per day or with identical tablets containing lactose. The healing rate, assessed by endoscopy, was 23 out of 35 (66%) in the patients given cimetidine and 13 out of 25 (52%) in those given placebo. The difference between the groups is not significant. During each of the four weeks of the study the cimetidine group experienced significantly fewer attacks of pain and consumed less antacids than the placebo treated patients.<\/jats:p>","DOI":"10.1136\/gut.20.8.730","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"730-734","source":"Crossref","is-referenced-by-count":25,"title":["Double-blind controlled trial of cimetidine in the healing of gastric ulcer."],"prefix":"10.1136","volume":"20","author":[{"given":"P J","family":"Ciclitira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Machell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Farthing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Dick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J O","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1979,8,1]]},"reference":[{"key":"ref_1","series-title":"Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists","first-page":"287","article-title":"Treatment of gastric ulcer by cimetidine a multicentre trial","author":"Bader, J.P.; Morin, T.; Bernier, J.J.; Bertrand, J.; Betourne, C.; Gastard, J.; Lambert, R.; Ribet, A.; Sarles, H.; Toulet, J.","year":"1977","unstructured":"Bader, J. P., Morin, T., Bernier, J. J., Bertrand, J., Betourne, C., Gastard, J., Lambert, R., Ribet, A., Sarles, H., and Toulet, J. (1977). Treatment of gastric ulcer by cimetidine a multicentre trial. In Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists, pp. 287-292. Edited by W. L. Burland and M. A. Simkins. Excerpta Medica: Amsterdam."},{"key":"ref_2","series-title":"of cimetidine in the treatment of gastric ulcer. In Cimetidine: Proceedings of the Second International Symposium on Histamine H2Receptor Antagonists","first-page":"283","article-title":"A controlled trial","author":"Burford, W.L.","year":"1976","unstructured":"Ciclitira, P. J., Machell, R. J., Farthing, M. J., Dick, A. P., and Hunter, J. 0. (1976). A controlled trial of cimetidine in the treatment of gastric ulcer. In Cimetidine: Proceedings of the Second International Symposium on Histamine H2Receptor Antagonists. pp. 283-286. Edited by W. L. Burford and M. A. Simkins. Excerpta Medica: Amsterdam."},{"key":"ref_3","first-page":"793","article-title":"Clinical trail of the triterpenoid liquorice compound in gastric and duodenal ulcer","volume":"2","author":"Doll, R.; Hill, I.D.; Hutton, C.; Underwood, D.J.U.","year":"1962","unstructured":"Doll, R., Hill, I. D., Hutton, C., and Underwood, D. J. U. (1962). Clinical trail of the triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet, 2, 793-796.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0016-5085(78)90773-4","article-title":"Cimetidine and placebo in the treatment of benign gastric ulcer","volume":"74","author":"Dyck, W.P.; Belsito, A.; Fleshier, B.; Liebermann, T.R.; Dickinson, P.B.; Wood, J.M.","year":"1978","unstructured":"Dyck, W. P., Belsito, A., Fleshier, B., Liebermann, T. R., Dickinson, P. B., and Wood, J. M. (1978). Cimetidine and placebo in the treatment of benign gastric ulcer. Gastroenterology, 74, 410-415.","journal-title":"Gastroenterology"},{"key":"ref_5","article-title":"Cimetidine, antacid, and hospitaliza-","author":"Englert, Jr., E.; Freston, J.W.; Graham, D.Y.; Finklestein, W.; Kruss, D.M.; Priest, R.J.; Raskin, J.B.; Rhodes, J.B.; Rogers, A.I.; Wenger, J.; Wilcox, L.L.; Crossley, R.J.","year":"1978","unstructured":"Englert, E., Jr., Freston, J. W., Graham, D. Y., Finklestein, W., Kruss, D. M., Priest, R. J., Raskin, J. B., Rhodes, J. B., Rogers, A. I., Wenger, J., Wilcox, L. L., and Crossley, R. J. (1978). Cimetidine, antacid, and hospitaliza-"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.20.8.730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T21:40:01Z","timestamp":1757281201000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.20.8.730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,8]]},"references-count":5,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1979,8,1]]},"published-print":{"date-parts":[[1979,8]]}},"alternative-id":["10.1136\/gut.20.8.730"],"URL":"https:\/\/doi.org\/10.1136\/gut.20.8.730","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1979,8]]}}}