{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:10Z","timestamp":1787017090727,"version":"build-2736575974"},"reference-count":20,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1979,9]]},"abstract":"<jats:p>Oesophageal biopsies were obtained from 74 patinets undergoing upper gastrointestinal fibreoptic endoscopy. Thirteen patients with histological evidence of inflammation had a raised alkaline phosphatase activity (2.7 +\/- 1.6 nmol\/mg protein\/min) compared with 49 normal controls (1.2 +\/- 0.68  nmol\/mg protein\/min: P less than 0.001). The acid phosphatase level was lower (8.4+\/- 4.0 vs. 5.8 +\/- 2.2 nmol\/mg protein\/min: P less than 0.05) and the glucuronidase activity raised (0.44 +\/- 0.17 vs 0.81 +\/- 0.32 nmol\/mg protein\/min: P less than 0.001) and their ratio declined (24.0 +\/- 1.9 nmol\/mg protein\/min: P less than 0.001) in patients with oesophagitis. This may be due to differential secretion of membrane coating granules, a form of lysosome found isophagitis--was assessed by point counting. The volume density rose from 10.9 +\/- 4.25% in normal biopsies to 46.4+\/-12.5% (P less than 0.001) in oesophagitis. These results show a consistent pattern that possibly indicates an intermediate stage between the clinically, histologically, and biochemically normal oesophagus and one that is inflamed on endoscopy.<\/jats:p>","DOI":"10.1136\/gut.20.9.769","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"769-774","source":"Crossref","is-referenced-by-count":6,"title":["Changes in enzyme activity in normal and histologically inflamed oesophageal epithelium."],"prefix":"10.1136","volume":"20","author":[{"given":"D","family":"Hopwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P E","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K R","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I A","family":"Bouchier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1979,9,1]]},"reference":[{"key":"ref_1","first-page":"387","article-title":"Histologic abnormalities in reflux esophagitis","volume":"99","author":"Behar, J.; Sheahan, D.C.","year":"1975","unstructured":"Behar, J., and Sheahan, D. 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