{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:18:12Z","timestamp":1773980292086,"version":"3.50.1"},"reference-count":31,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2004,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The role of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    eradication in the management of gastro-oesophageal reflux disease (GORD) is controversial. We hypothesised that\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication leads to worsened control of reflux disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Consecutive patients with weekly reflux symptoms were prospectively recruited for endoscopy and symptom evaluation. Patients were enrolled if they had\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection and required long term acid suppressants. Eligible patients were randomly assigned to omeprazole triple therapy (\n                    <jats:italic>Hp<\/jats:italic>\n                    E group) or omeprazole with placebo antibiotics (\n                    <jats:italic>Hp<\/jats:italic>\n                    + group) for one week. Omeprazole 20 mg daily was given for eight weeks for healing of oesophagitis and symptom relief. This was followed by a maintenance dose of 10 mg daily for up to 12 months. The primary study end point was the probability of treatment failure within 12 months, which was defined as either incomplete resolution of symptoms or oesophagitis at the initial treatment phase, or relapse of symptoms and oesophagitis during the maintenance phase. Predictors of treatment failure were determined by Cox\u2019s proportional hazards model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 236 GORD patients were screened and 113 (47.9%) were positive for\n                    <jats:italic>H pylori<\/jats:italic>\n                    ; 104 (92%) patients were included in the intention to treat analysis (53 in the\n                    <jats:italic>Hp<\/jats:italic>\n                    E group and 51 in the\n                    <jats:italic>Hp<\/jats:italic>\n                    + group). Thirty one patients (30%) had erosive oesophagitis at baseline.\n                    <jats:italic>H pylori<\/jats:italic>\n                    was eradicated in 98% of the\n                    <jats:italic>Hp<\/jats:italic>\n                    E group and in 3.9% of the\n                    <jats:italic>Hp<\/jats:italic>\n                    + group. Overall, 15 patients (28.3%) in the\n                    <jats:italic>Hp<\/jats:italic>\n                    E group and eight patients (15.7%) in the\n                    <jats:italic>Hp<\/jats:italic>\n                    + group had treatment failure. The 12 month probability of treatment failure was 43.2% (95% confidence interval (CI) 29.9\u201356.5%) in the\n                    <jats:italic>Hp<\/jats:italic>\n                    E group and 21.1% (95% CI 9.9\u201332.3%) in the\n                    <jats:italic>Hp<\/jats:italic>\n                    + group (log rank test, p\u200a=\u200a0.043). In the Cox proportional hazards model, after adjustment for the covariates age, sex, erosive oesophagitis, hiatus hernia, degree of gastritis, and severity of symptoms at baseline,\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication was the only predictor of treatment failure (adjusted hazard ratio 2.47 (95% CI 1.05\u20135.85)).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    <jats:italic>H pylori<\/jats:italic>\n                    eradication leads to more resilient GORD.\n                  <\/jats:p>","DOI":"10.1136\/gut.2003.012641","type":"journal-article","created":{"date-parts":[[2004,1,14]],"date-time":"2004-01-14T16:55:32Z","timestamp":1074099332000},"page":"174-179","source":"Crossref","is-referenced-by-count":58,"title":["Effect of\n                    <i>Helicobacter pylori<\/i>\n                    eradication on treatment of gastro-oesophageal reflux disease: a double blind, placebo controlled, randomised trial"],"prefix":"10.1136","volume":"53","author":[{"given":"J C Y","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F K L","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Y L","family":"Ching","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W-K","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Leong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S C S","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J Y","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2004,1,14]]},"reference":[{"key":"2025112109044836000_53.2.174.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510263331703"},{"key":"2025112109044836000_53.2.174.2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/gut.44.2008.S1","volume":"44","year":"1999","journal-title":"Gut"},{"key":"2025112109044836000_53.2.174.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01207.x"},{"key":"2025112109044836000_53.2.174.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00460.x"},{"key":"2025112109044836000_53.2.174.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70075-1"},{"key":"2025112109044836000_53.2.174.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.4.539"},{"key":"2025112109044836000_53.2.174.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70544-5"},{"key":"2025112109044836000_53.2.174.8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.37.6.743"},{"key":"2025112109044836000_53.2.174.9","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00042737-200107000-00009","volume":"13","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025112109044836000_53.2.174.10","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29332"},{"key":"2025112109044836000_53.2.174.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04894-7"},{"key":"2025112109044836000_53.2.174.12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01189.x"},{"key":"2025112109044836000_53.2.174.13","first-page":"93","volume":"72","year":"1999","journal-title":"Yale J Biol Med"},{"key":"2025112109044836000_53.2.174.14","first-page":"1161","volume":"10","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"2025112109044836000_53.2.174.15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1136\/gut.43.4.458","volume":"43","year":"1998","journal-title":"Gut"},{"key":"2025112109044836000_53.2.174.16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2036.1998.00272.x","volume":"12","year":"1998","journal-title":"Aliment Pharmacol Ther"},{"key":"2025112109044836000_53.2.174.17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00544.x"},{"key":"2025112109044836000_53.2.174.18","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018835324210"},{"key":"2025112109044836000_53.2.174.19","first-page":"668","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025112109044836000_53.2.174.20","first-page":"II78","volume":"45","year":"1999","journal-title":"Gut"},{"key":"2025112109044836000_53.2.174.21","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9270(00)00775-9","volume":"95","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"2025112109044836000_53.2.174.22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2000.00032.x"},{"key":"2025112109044836000_53.2.174.23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/gut.44.4.468","volume":"44","year":"1999","journal-title":"Gut"},{"key":"2025112109044836000_53.2.174.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70118-6"},{"key":"2025112109044836000_53.2.174.25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01593.x"},{"key":"2025112109044836000_53.2.174.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70024-6"},{"key":"2025112109044836000_53.2.174.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00723-9"},{"key":"2025112109044836000_53.2.174.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341603"},{"key":"2025112109044836000_53.2.174.29","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1999.0029900319"},{"key":"2025112109044836000_53.2.174.30","doi-asserted-by":"crossref","first-page":"A14","DOI":"10.1016\/S0016-5085(08)80071-6","volume":"120","year":"2001","journal-title":"Gastroenterology"},{"key":"2025112109044836000_53.2.174.31","first-page":"167","volume":"16","year":"2002","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2003.012641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:04:55Z","timestamp":1763744695000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2003.012641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,14]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,1,14]]},"published-print":{"date-parts":[[2004,2]]}},"alternative-id":["10.1136\/gut.2003.012641"],"URL":"https:\/\/doi.org\/10.1136\/gut.2003.012641","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,14]]}}}