{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:08:08Z","timestamp":1791900488283,"version":"4.3.4"},"reference-count":48,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>\n                  <jats:bold>Background:<\/jats:bold> Lymphocytic colitis is characterised by chronic diarrhoea and specific microscopic changes in a macroscopically normal colonic mucosa. We report clinical features and treatment outcome in a large patient cohort.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Patients were searched for in 24 Swedish gastroenterology clinics. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical notes.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Lymphocytic colitis was diagnosed in 199 cases. The female:male ratio was 2.4:1. Median age at diagnosis was 59 (48\u201370) years. The most frequent symptoms were diarrhoea (96%), abdominal pain (47%), and weight loss (41%). The course was chronic intermittent in 30% of patients, chronic continuous in 7%, and a single attack in 63%, and in these cases the disease duration was 6 (4\u201311) months. Seventy nine (40%) patients reported associated diseases, of which thyroid disorders, coeliac disease, and diabetes mellitus were the most common. In 34 first or second degree relatives of 24 (12%) patients, a family history of ulcerative colitis, Crohn\u2019s disease, collagenous colitis, or coeliac disease was reported. Drug induced disease was suspected in 19 (10%) patients. A non-significant peak of disease onset was seen in December-January. More than 80% of treated patients improved on corticosteroids, including budesonide.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> A family history of other bowel disorders is a new finding. The sudden onset and single attack of limited duration may support a possible infectious cause in some cases. Drugs may cause lymphocytic colitis.<\/jats:p>","DOI":"10.1136\/gut.2003.023440","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T20:34:27Z","timestamp":1079037267000},"page":"536-541","source":"Crossref","is-referenced-by-count":181,"title":["Lymphocytic colitis: a retrospective clinical study of 199 Swedish 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