{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:04:14Z","timestamp":1791223454918,"version":"4.1.0"},"reference-count":46,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    We investigated the effects of an interleukin 8 (IL-8) gene polymorphism on the risk of gastroduodenal diseases, the degree of\n                    <jats:italic>H pylori<\/jats:italic>\n                    induced gastritis, and\n                    <jats:italic>IL-8<\/jats:italic>\n                    gene transcription.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects:<\/jats:bold>\n                    The study was performed in 244 healthy control subjects and 690\n                    <jats:italic>H pylori<\/jats:italic>\n                    positive patients with non-cardia gastric cancer, gastric ulcer, duodenal ulcer, or gastritis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We identified the\n                    <jats:italic>IL-8<\/jats:italic>\n                    \u2212251 A\/T polymorphism by direct sequence analysis, and measured the gastritis score and serum pepsinogen (PG). The transcriptional promoter activity of the\n                    <jats:italic>IL-8<\/jats:italic>\n                    gene was assessed by luciferase assay.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    <jats:italic>IL-8<\/jats:italic>\n                    \u2212251A was associated with a higher risk of gastric cancer and gastric ulcer. Patients carrying\n                    <jats:italic>IL-8<\/jats:italic>\n                    \u2212251A showed an increased risk of gastric cancer (odds ratios (OR) 2.01 (95% confidence interval (CI) 1.38\u20132.92)) and gastric ulcer (OR 2.07 (95% CI 1.37\u20133.12)). Compared with patients younger than 49 years, atrophy and metaplasia scores in the antrum were significantly higher and the PG I\/II ratio significantly lower in \u2212251A carriers than in T\/T carriers. In the in vitro assay,\n                    <jats:italic>IL-8<\/jats:italic>\n                    \u2212251A showed enhanced promoter activity in response to IL-1\u03b2 or tumour necrosis factor \u03b1.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The\n                    <jats:italic>IL-8<\/jats:italic>\n                    \u2212251A allele may be associated with progression of gastric atrophy in patients with\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people.\n                  <\/jats:p>","DOI":"10.1136\/gut.2003.033050","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T18:13:06Z","timestamp":1108145586000},"page":"330-335","source":"Crossref","is-referenced-by-count":180,"title":["The polymorphism interleukin 8 \u2212251 A\/T influences the susceptibility of\n                    <i>Helicobacter pylori<\/i>\n                    related gastric diseases in the Japanese 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