{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:00:49Z","timestamp":1789952449487,"version":"4.0.1"},"reference-count":51,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>\n                  <jats:bold>Background and aims:<\/jats:bold> Genome wide scans in inflammatory bowel disease (IBD) have indicated various susceptibility regions with replication of 16cen (<jats:italic>IBD1<\/jats:italic>), 12q (<jats:italic>IBD2<\/jats:italic>), 6p (<jats:italic>IBD3<\/jats:italic>), 14q11 (<jats:italic>IBD4<\/jats:italic>), and 3p21. As no linkage was previously found on IBD regions 3, 7, 12, and 16 in Flemish IBD families, a genome wide scan was performed to detect other susceptibility regions in this population.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> A cohort of 149 IBD affected relative pairs, all recruited from the Northern Flemish part of Belgium, were genotyped using microsatellite markers at 12 cM intervals, and analysed by Genehunter non-parametric linkage software. All families were further genotyped for the three main Crohn\u2019s disease associated variants in the NOD2\/CARD15 gene.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Nominal evidence for linkage was observed on chromosomes 1 (D1S197: multipoint non-parametric linkage (NPL) score 2.57, p\u200a=\u200a0.004; and at D1S305-D1S252: NPL 2.97, p\u200a=\u200a0.001), 4q (D4S406: NPL 1.95, p\u200a=\u200a0.03), 6q16 (D6S314: NPL 2.44, p\u200a=\u200a0.007), 10p12 (D10S197: NPL 2.05, p\u200a=\u200a0.02), 11q22 (D11S35-D11S927: NPL 1.95, p\u200a=\u200a0.02) 14q11-12 (D14S80: NPL 2.41, p\u200a=\u200a0.008), 20p12 (D20S192: NPL 2.7, p\u200a=\u200a0.003), and Xq (DXS990: NPL 1.70, p\u200a=\u200a0.04). A total of 51.4% of patients carried at least one NOD2\/CARD15 variant. Furthermore, epistasis was observed between susceptibility regions 6q\/10p and 20p\/10p.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> Genome scanning in a Flemish IBD population found nominal evidence for linkage on 1p, 4q, 10p12, and 14q11, overlapping with other genome scan results, with linkage on 14q11-12 supporting the <jats:italic>IBD4<\/jats:italic> locus. The results further show that epistasis is contributing to the complex model of IBD and indicate that population heterogeneity is not to be underestimated. Finally, NOD2\/CARD15 is clearly implicated in the Flemish IBD population.<\/jats:p>","DOI":"10.1136\/gut.2003.034033","type":"journal-article","created":{"date-parts":[[2004,6,11]],"date-time":"2004-06-11T23:18:02Z","timestamp":1086995882000},"page":"980-986","source":"Crossref","is-referenced-by-count":62,"title":["Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis"],"prefix":"10.1136","volume":"53","author":[{"given":"S","family":"Vermeire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rutgeerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Van Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Joossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Claessens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pierik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Vlietinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2004,6,11]]},"reference":[{"key":"2025090723343753000_53.7.980.1","unstructured":"Calkins BM, Mendelhoff AI. 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