{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:22:31Z","timestamp":1791588151205,"version":"4.3.4"},"reference-count":16,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background and aims:<\/jats:bold>\n                    The risk of colorectal cancer is increased in ulcerative colitis (UC). Patients with UC have diverse colonoscopic appearances. Determining colonoscopic markers for cancer risk could allow patient risk stratification.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    Following on from an earlier study which demonstrated a correlation between inflammation severity and neoplasia risk, a case control study was performed to look for colonoscopic markers of colorectal neoplasia risk in UC. Each patient with neoplasia detected between 1988 and 2002 was matched with two non-dysplastic colitic controls. Data were collected on post-inflammatory polyps, scarring, strictures, backwash ileitis, a shortened, tubular, or featureless colon, severe inflammation, and normal looking surveillance colonoscopies.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Cases (n\u200a=\u200a68) and controls (n\u200a=\u200a136) were well matched. On univariate analysis, cases were significantly more likely to have post-inflammatory polyps (odds ratio (OR) 2.14 (95% confidence interval 1.24\u20133.70)), strictures (OR 4.22; 1.08\u201315.54), shortened colons (OR 10.0; 1.17\u201385.6), tubular colons (OR 2.03; 1.00\u20134.08), or segments of severe inflammation (OR 3.38; 1.41\u201310.13), and less likely to have had a macroscopically normal looking colonoscopy (OR 0.40; 0.21\u20130.74). After multivariate analysis, a macroscopically normal looking colonoscopy (OR 0.38; 0.19\u20130.73), post-inflammatory polyps (2.29; 1.28\u20134.11), and strictures (4.62; 1.03\u201320.8) remained significant. The five year risk of colorectal cancer following a normal looking colonoscopy was no different from that of matched general population controls.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Macroscopic colonoscopic features help predict neoplasia risk in UC. Features of previous\/ongoing inflammation signify an increased risk. A macroscopically normal looking colonoscopy returns the cancer risk to that of the general population: it should be possible to reduce surveillance frequency to five years in this cohort.\n                  <\/jats:p>","DOI":"10.1136\/gut.2003.038505","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T21:48:21Z","timestamp":1100209701000},"page":"1813-1816","source":"Crossref","is-referenced-by-count":358,"title":["Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk"],"prefix":"10.1136","volume":"53","author":[{"given":"M D","family":"Rutter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B P","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K 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