{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:57:08Z","timestamp":1787803028744,"version":"build-2784847793"},"reference-count":89,"publisher":"BMJ","issue":"suppl 1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>\n                    The incidence of oesophageal adenocarcinoma is increasing and the prognosis is poor. There is a strong predominance of white males, and heredity plays a minor role. The established risk factors are Barrett\u2019s oesophagus, gastro-oesophageal reflux, and obesity. Infection with\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    and use of non-steroidal anti-inflammatory drugs might reduce the risk. Medications that relax the lower oesophageal sphincter might contribute to increasing the risk. Among dietary factors, low intake of fruit, vegetables, and cereal fibres seem to increase the risk of oesophageal adenocarcinoma. The role of tobacco smoking is probably limited and alcohol consumption is not a risk factor. It is uncertain which factors cause the increasing incidence. Increasing prevalences of reflux and obesity, and decreasing prevalence of\n                    <jats:italic>H pylori<\/jats:italic>\n                    infection may contribute to this development; however, the sex distributions of these factors do not match the incidence trends well. Endoscopic surveillance for oesophageal adenocarcinoma among persons with reflux and obesity is discussed, but presently there is no evidence that strongly supports such a strategy.\n                  <\/jats:p>","DOI":"10.1136\/gut.2004.041517","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T19:02:38Z","timestamp":1108148558000},"page":"i1-i5","source":"Crossref","is-referenced-by-count":175,"title":["Adenocarcinoma of oesophagus: what exactly is the size of the problem and who is at risk?: \n            Table 1"],"prefix":"10.1136","volume":"54","author":[{"given":"J","family":"Lagergren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,2,11]]},"reference":[{"key":"2025121304173404000_54.suppl_1.i1.1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10420"},{"key":"2025121304173404000_54.suppl_1.i1.2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00052937"},{"key":"2025121304173404000_54.suppl_1.i1.3","unstructured":"Survival of Cancer Patients in Europe: The EUROCARE II Study . Lyon: International Agency for Research on Cancer, 1999."},{"key":"2025121304173404000_54.suppl_1.i1.4","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430190030008"},{"key":"2025121304173404000_54.suppl_1.i1.5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840143"},{"key":"2025121304173404000_54.suppl_1.i1.6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880201)61:3<612::AID-CNCR2820610332>3.0.CO;2-Q"},{"key":"2025121304173404000_54.suppl_1.i1.7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890715)64:2<526::AID-CNCR2820640228>3.0.CO;2-B"},{"key":"2025121304173404000_54.suppl_1.i1.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460100089030"},{"key":"2025121304173404000_54.suppl_1.i1.9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/0016-5085(93)90420-H","volume":"104","year":"1993","journal-title":"Gastroenterology"},{"key":"2025121304173404000_54.suppl_1.i1.10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950101)75:1+<154::AID-CNCR2820751305>3.0.CO;2-Z"},{"key":"2025121304173404000_54.suppl_1.i1.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2049::AID-CNCR1>3.0.CO;2-2"},{"key":"2025121304173404000_54.suppl_1.i1.12","first-page":"1904","volume":"149","year":"1987","journal-title":"Kraeftstatistik nr.19. Ugeskr Laeger"},{"key":"2025121304173404000_54.suppl_1.i1.13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00008469-199204000-00008","volume":"1","year":"1992","journal-title":"Eur J Cancer Prev"},{"key":"2025121304173404000_54.suppl_1.i1.14","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.5.941"},{"key":"2025121304173404000_54.suppl_1.i1.15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970502)71:3<340::AID-IJC5>3.0.CO;2-Y"},{"key":"2025121304173404000_54.suppl_1.i1.16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/ijc.2910540309","volume":"54","year":"1993","journal-title":"Int J Cancer"},{"key":"2025121304173404000_54.suppl_1.i1.17","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010801)92:3<549::AID-CNCR1354>3.0.CO;2-L"},{"key":"2025121304173404000_54.suppl_1.i1.18","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352846"},{"key":"2025121304173404000_54.suppl_1.i1.19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.3.323"},{"key":"2025121304173404000_54.suppl_1.i1.20","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-1-52"},{"key":"2025121304173404000_54.suppl_1.i1.21","first-page":"86","volume":"33","year":"1986","journal-title":"Hepatogastroenterology"},{"key":"2025121304173404000_54.suppl_1.i1.22","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/0016-5085(92)90784-V","volume":"102","year":"1992","journal-title":"Gastroenterology"},{"key":"2025121304173404000_54.suppl_1.i1.23","unstructured":"Eng C , Spechler SJ, Ruben R, et al. Familial Barrett\u2019s esophagus and adenocarcinoma of the gastroesophageal junction. Cancer Epidemiol Biomarkers Prev 1993;2:397\u20139."},{"key":"2025121304173404000_54.suppl_1.i1.24","first-page":"1855","volume":"91","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"2025121304173404000_54.suppl_1.i1.25","first-page":"761","volume":"5","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121304173404000_54.suppl_1.i1.26","first-page":"757","volume":"9","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121304173404000_54.suppl_1.i1.27","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1294"},{"key":"2025121304173404000_54.suppl_1.i1.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"2025121304173404000_54.suppl_1.i1.29","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(84)90090-8","volume":"87","year":"1984","journal-title":"Gastroenterology"},{"key":"2025121304173404000_54.suppl_1.i1.30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1056\/NEJM198510033131404","volume":"313","year":"1985","journal-title":"N Engl J Med"},{"key":"2025121304173404000_54.suppl_1.i1.31","first-page":"760","volume":"72","year":"1988","journal-title":"Br J Surg"},{"key":"2025121304173404000_54.suppl_1.i1.32","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0016-5085(89)80011-3","volume":"96","year":"1989","journal-title":"Gastroenterology"},{"key":"2025121304173404000_54.suppl_1.i1.33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.1.14"},{"key":"2025121304173404000_54.suppl_1.i1.34","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538065"},{"key":"2025121304173404000_54.suppl_1.i1.35","first-page":"212","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121304173404000_54.suppl_1.i1.36","first-page":"369","volume":"6","year":"1997","journal-title":"Cancer Epidemiol Biomarks Prev"},{"key":"2025121304173404000_54.suppl_1.i1.37","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530060048032"},{"key":"2025121304173404000_54.suppl_1.i1.38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"2025121304173404000_54.suppl_1.i1.39","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008913828105"},{"key":"2025121304173404000_54.suppl_1.i1.40","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29569"},{"key":"2025121304173404000_54.suppl_1.i1.41","first-page":"165","volume":"133","year":"2000","journal-title":"Ann Intern Med"},{"key":"2025121304173404000_54.suppl_1.i1.42","first-page":"749","volume":"7","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121304173404000_54.suppl_1.i1.43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/oxfordjournals.bmb.a011611","volume":"53","year":"1997","journal-title":"Br Med Bull"},{"key":"2025121304173404000_54.suppl_1.i1.44","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03520030047027"},{"key":"2025121304173404000_54.suppl_1.i1.45","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.2.104"},{"key":"2025121304173404000_54.suppl_1.i1.46","first-page":"85","volume":"4","year":"1995","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121304173404000_54.suppl_1.i1.47","first-page":"481","volume":"6","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121304173404000_54.suppl_1.i1.48","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.2.150"},{"key":"2025121304173404000_54.suppl_1.i1.49","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-11-199906010-00003"},{"key":"2025121304173404000_54.suppl_1.i1.50","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011290704728"},{"key":"2025121304173404000_54.suppl_1.i1.51","doi-asserted-by":"publisher","DOI":"10.1007\/BF00053153"},{"key":"2025121304173404000_54.suppl_1.i1.52","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/ijc.2910430502","volume":"43","year":"1989","journal-title":"Int J Cancer"},{"key":"2025121304173404000_54.suppl_1.i1.53","first-page":"2569","volume":"50","year":"1990","journal-title":"Cancer Res"},{"key":"2025121304173404000_54.suppl_1.i1.54","doi-asserted-by":"publisher","DOI":"10.1007\/BF01804984"},{"key":"2025121304173404000_54.suppl_1.i1.55","doi-asserted-by":"publisher","DOI":"10.1007\/BF01830731"},{"key":"2025121304173404000_54.suppl_1.i1.56","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.17.1277"},{"key":"2025121304173404000_54.suppl_1.i1.57","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ijc.2910450511","volume":"45","year":"1990","journal-title":"Int J Cancer"},{"key":"2025121304173404000_54.suppl_1.i1.58","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910580208"},{"key":"2025121304173404000_54.suppl_1.i1.59","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000201)85:3<340::AID-IJC8>3.0.CO;2-N"},{"key":"2025121304173404000_54.suppl_1.i1.60","first-page":"588","volume":"58","year":"1998","journal-title":"Cancer Res"},{"key":"2025121304173404000_54.suppl_1.i1.61","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.1998.08031.x"},{"key":"2025121304173404000_54.suppl_1.i1.62","doi-asserted-by":"publisher","DOI":"10.1159\/000007820"},{"key":"2025121304173404000_54.suppl_1.i1.63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01758.x"},{"key":"2025121304173404000_54.suppl_1.i1.64","first-page":"310","volume":"4","year":"2001","journal-title":"Helicobacter"},{"key":"2025121304173404000_54.suppl_1.i1.65","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh057"},{"key":"2025121304173404000_54.suppl_1.i1.66","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10887"},{"key":"2025121304173404000_54.suppl_1.i1.67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00523.x"},{"key":"2025121304173404000_54.suppl_1.i1.68","doi-asserted-by":"crossref","first-page":"3467S","DOI":"10.1093\/jn\/132.11.3467S","volume":"132","year":"2002","journal-title":"J Nutr"},{"key":"2025121304173404000_54.suppl_1.i1.69","first-page":"1055","volume":"10","year":"2001","journal-title":"Cancer Epidemiol Biomarks Prev"},{"key":"2025121304173404000_54.suppl_1.i1.70","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200108000-00010"},{"key":"2025121304173404000_54.suppl_1.i1.71","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000901)87:5<750::AID-IJC19>3.0.CO;2-6"},{"key":"2025121304173404000_54.suppl_1.i1.72","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21171"},{"key":"2025121304173404000_54.suppl_1.i1.73","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.20.1529"},{"key":"2025121304173404000_54.suppl_1.i1.74","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.21.1609"},{"key":"2025121304173404000_54.suppl_1.i1.75","first-page":"2929","volume":"58","year":"1998","journal-title":"Cancer Res"},{"key":"2025121304173404000_54.suppl_1.i1.76","first-page":"198","volume":"59","year":"1999","journal-title":"Cancer Res"},{"key":"2025121304173404000_54.suppl_1.i1.77","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70254-X"},{"key":"2025121304173404000_54.suppl_1.i1.78","first-page":"5767","volume":"60","year":"2000","journal-title":"Cancer Res"},{"key":"2025121304173404000_54.suppl_1.i1.79","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951001)76:7<1116::AID-CNCR2820760703>3.0.CO;2-I"},{"key":"2025121304173404000_54.suppl_1.i1.80","first-page":"1322","volume":"53","year":"1993","journal-title":"Cancer Res"},{"key":"2025121304173404000_54.suppl_1.i1.81","first-page":"97","volume":"7","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025121304173404000_54.suppl_1.i1.82","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.3.327"},{"key":"2025121304173404000_54.suppl_1.i1.83","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"2025121304173404000_54.suppl_1.i1.84","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071906"},{"key":"2025121304173404000_54.suppl_1.i1.85","first-page":"46","volume":"126","year":"1982","journal-title":"Canadian Medical Association Journal"},{"key":"2025121304173404000_54.suppl_1.i1.86","unstructured":"Cancer Registry. Cancer incidence in Sweden 1993, 1994 and 1995. Stockholm: National Board of Health and Welfare, 1996, 1997, and, 1998."},{"key":"2025121304173404000_54.suppl_1.i1.87","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ssu.2980060509","volume":"6","year":"1990","journal-title":"Semin Surg Oncol"},{"key":"2025121304173404000_54.suppl_1.i1.88","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.8.961"},{"key":"2025121304173404000_54.suppl_1.i1.89","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-3-200302040-00009"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2004.041517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T12:17:50Z","timestamp":1765628270000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2004.041517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,11]]},"references-count":89,"journal-issue":{"issue":"suppl 1","published-online":{"date-parts":[[2005,2,11]]},"published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1136\/gut.2004.041517"],"URL":"https:\/\/doi.org\/10.1136\/gut.2004.041517","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,11]]}}}