{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:30:02Z","timestamp":1789500602726,"version":"build-2803163510"},"reference-count":45,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2005,11]]},"abstract":"\n Background:<\/jats:bold>\n Osteoporosis is an important cause of morbidity in patients with Crohn\u2019s disease. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis.\n <\/jats:p>\n \n Aim:<\/jats:bold>\n To investigate the influence of interleukin 6 (\n IL-6<\/jats:italic>\n ), collagen type 1\u03b11 (\n COL1A1<\/jats:italic>\n ), and vitamin D receptor gene (\n VDR<\/jats:italic>\n ) single nucleotide polymorphisms (SNP) on BMD in patients with Crohn\u2019s disease.\n <\/jats:p>\n \n Patients:<\/jats:bold>\n A cohort of 245 well characterised patients with Crohn\u2019s disease were recruited from the inflammatory bowel disease register at the Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne, and the Queen Elizabeth Hospital, Gateshead, UK.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n Patients were genotyped for\n IL-6<\/jats:italic>\n C-174G SNP,\n COL1A1<\/jats:italic>\n Sp1 binding site G T SNP,\n VDR Taq1<\/jats:italic>\n , and\n Fok1<\/jats:italic>\n SNPs, and\n CARD15<\/jats:italic>\n R702W, G908R, and L1007fs SNPs. BMD was measured at the lumbar spine (LSP) and hip using dual energy\n x<\/jats:italic>\n ray absorptiometry.\n <\/jats:p>\n \n Results:<\/jats:bold>\n A total of 158 female and 87 male patients, aged 24\u201370 years (mean 44), were recruited. There were no significant differences in the distribution of the tested SNPs when analysed for age, body mass index, pre\/post-menopausal status, smoking, or steroid use. Two hundred and thirteen patients were genotyped for the\n IL-6<\/jats:italic>\n SNP. LSP and total hip BMD was significantly lower in patients with the GG genotype (48%) than the CC genotype (15%) (p\u200a=\u200a0.041, p\u200a=\u200a0.014). One hundred and eighty patients were genotyped for the\n COL1A1<\/jats:italic>\n SNP. There was no significant difference in BMD at LSP. Hip BMD was significantly lower in heterozygous patients compared with homozygous wild-types (p\u200a=\u200a0.034). There were no significant differences in BMD between genotypes for the two\n VDR<\/jats:italic>\n SNPs or the\n CARD15<\/jats:italic>\n genotypes examined.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n IL-6<\/jats:italic>\n and\n COL1A1<\/jats:italic>\n gene polymorphisms influence BMD in patients with Crohn\u2019s disease but the particular\n VDR<\/jats:italic>\n gene polymorphisms studied do not have a major effect.\n <\/jats:p>","DOI":"10.1136\/gut.2005.064212","type":"journal-article","created":{"date-parts":[[2005,7,11]],"date-time":"2005-07-11T20:23:54Z","timestamp":1121113434000},"page":"1579-1584","source":"Crossref","is-referenced-by-count":33,"title":["Influence of\n IL-6<\/i>\n ,\n COL1A1<\/i>\n , and\n VDR<\/i>\n gene polymorphisms on bone mineral density in Crohn\u2019s disease"],"prefix":"10.1136","volume":"54","author":[{"given":"C 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