{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:51:34Z","timestamp":1784119894749,"version":"3.55.0"},"reference-count":60,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Gastric emptying is frequently delayed in critical illness which compromises the success of nasogastric nutrition. The underlying motor dysfunctions are poorly defined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aims:<\/jats:bold>\n                    To characterise antro-pyloro-duodenal motility during fasting, and in response to gastric and duodenal nutrient, as well as to evaluate the relationship between gastric emptying and motility, in the critically ill.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects:<\/jats:bold>\n                    Fifteen mechanically ventilated patients from a mixed intensive care unit; 10 healthy volunteers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Antro-pyloro-duodenal pressures were recorded during fasting, after intragastric administration (100 ml; 100 kcal), and during small intestinal infusion of liquid nutrient (6 hours; 1 kcal\/min). Gastric emptying was measured using a\n                    <jats:sup>13<\/jats:sup>\n                    C octanoate breath test.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    In healthy subjects, neither gastric nor small intestinal nutrient affected antro-pyloro-duodenal pressures. In patients, duodenal nutrient infusion reduced antral activity compared with both fasting and healthy subjects (0.03 (0\u20132.47) waves\/min\n                    <jats:italic>v<\/jats:italic>\n                    0.14 (0\u20132.2) fasting (p\u200a=\u200a0.016); and\n                    <jats:italic>v<\/jats:italic>\n                    0.33 (0\u20132.57)\/min in healthy subjects (p\u200a=\u200a0.005)). Basal pyloric pressure and the frequency of phasic pyloric pressure waves were increased in patients during duodenal nutrient infusion (3.12 (1.06) mm Hg; 0.98 (0.13)\/min) compared with healthy subjects (\u22120.44 (1.25) mm Hg; p&lt;0.02 after 120 minutes; 0.29 (0.15)\/min; p\u200a=\u200a0.0002) and with fasting (\u22120.06 (1.05) mm Hg; p&lt;0.03 after 160 minutes; 0.49 (0.13)\/min; (p\u200a=\u200a0.0001). Gastric emptying was delayed in patients (gastric emptying coefficient 2.99 (0.2)\n                    <jats:italic>v<\/jats:italic>\n                    3.47 (0.1); p\u200a=\u200a0.015) and inversely related to the number of pyloric pressure waves (\n                    <jats:italic>r<\/jats:italic>\n                    \u200a=\u200a\u22120.563, p\u200a=\u200a0.029).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Stimulation of pyloric and suppression of antral pressures by duodenal nutrient are enhanced in the critically ill and related to decreased gastric emptying.\n                  <\/jats:p>","DOI":"10.1136\/gut.2005.065672","type":"journal-article","created":{"date-parts":[[2005,5,29]],"date-time":"2005-05-29T20:18:16Z","timestamp":1117397896000},"page":"1384-1390","source":"Crossref","is-referenced-by-count":91,"title":["Antro-pyloro-duodenal motor responses to gastric and duodenal 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