{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:49:36Z","timestamp":1791910176641,"version":"4.3.4"},"reference-count":42,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>\n                  <jats:bold>Background and aims:<\/jats:bold> Activation of the vanilloid receptor subtype 1 (VR-1) results in release of proinflammatory peptides which initiate an inflammatory cascade known as neurogenic inflammation. We investigated its role in an acute model of surgically induced oesophagitis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Oesophagitis was induced by pyloric ligation in wild-type and VR-1 deficient mice. A subset of animals were administered the VR-1 antagonist capsazepine, famotidine, or omeprazole one hour before surgery. Five hours after surgery, myeloperoxidase activity (MPO), histological damage scores, intragastric pH, and immunocytochemical analysis of substance P (SP) receptor endocytosis were determined.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Oesophagitis induced knockout mice exhibited significantly lower levels of MPO activity, histological damage scores, and SP receptor endocytosis than wild-type mice. Inflammatory parameters were significantly reduced by acid inhibition and capsazepine in wild-type mice.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> We conclude that acute acid induced oesophagitis is reduced in animals lacking VR-1. This suggests that acid induced oesophagitis may act through VR-1 and that inhibition of the receptor may reduce inflammation.<\/jats:p>","DOI":"10.1136\/gut.2005.066795","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T22:53:39Z","timestamp":1123628019000},"page":"34-40","source":"Crossref","is-referenced-by-count":40,"title":["Attenuation of acid induced oesophagitis in VR-1 deficient mice"],"prefix":"10.1136","volume":"55","author":[{"given":"K","family":"Fujino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Takami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C R","family":"Mantyh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,8,9]]},"reference":[{"key":"2025090712522310000_55.1.34.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01071906"},{"key":"2025090712522310000_55.1.34.2","doi-asserted-by":"crossref","first-page":"G1322","DOI":"10.1152\/ajpgi.2001.281.5.G1322","volume":"281","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2025090712522310000_55.1.34.3","first-page":"713","volume":"5","year":"2003","journal-title":"Gut"},{"key":"2025090712522310000_55.1.34.4","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90112-0"},{"key":"2025090712522310000_55.1.34.5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898641"},{"key":"2025090712522310000_55.1.34.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5282.1722"},{"key":"2025090712522310000_55.1.34.7","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0744-8_24"},{"key":"2025090712522310000_55.1.34.8","first-page":"34","volume":"90","year":"2003","journal-title":"Ann Allerg Asthma Im"},{"key":"2025090712522310000_55.1.34.9","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.032797"},{"key":"2025090712522310000_55.1.34.10","doi-asserted-by":"publisher","DOI":"10.1038\/32904"},{"key":"2025090712522310000_55.1.34.11","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5336.275"},{"key":"2025090712522310000_55.1.34.12","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1993.1156"},{"key":"2025090712522310000_55.1.34.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.6.756"},{"key":"2025090712522310000_55.1.34.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00459-X"},{"key":"2025090712522310000_55.1.34.15","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0016-5085(78)90417-1","volume":"75","year":"1978","journal-title":"Gastroenterology"},{"key":"2025090712522310000_55.1.34.16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90379-R"},{"key":"2025090712522310000_55.1.34.17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12356.x"},{"key":"2025090712522310000_55.1.34.18","doi-asserted-by":"publisher","DOI":"10.1038\/22761"},{"key":"2025090712522310000_55.1.34.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155"},{"key":"2025090712522310000_55.1.34.20","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.035063"},{"key":"2025090712522310000_55.1.34.21","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.043893"},{"key":"2025090712522310000_55.1.34.22","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(88)90029-4"},{"key":"2025090712522310000_55.1.34.23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0021-5198(19)52665-8","volume":"32","year":"1982","journal-title":"Jpn J Pharmacol"},{"key":"2025090712522310000_55.1.34.24","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"2025090712522310000_55.1.34.25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8841"},{"key":"2025090712522310000_55.1.34.26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00287.2001"},{"key":"2025090712522310000_55.1.34.27","doi-asserted-by":"crossref","unstructured":"Mathews P, As\u00eds Q, Facer P, et al. 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