{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:49:46Z","timestamp":1791910186116,"version":"4.3.4"},"reference-count":52,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To obtain a better understanding of nociceptive processing in patients with oesophagitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    Eleven patients with grade B oesophagitis were compared with an age and sex matched group of 16 healthy subjects. A probe was positioned in the lower part of the oesophagus. After preconditioning of the tissue, painful mechanical stimuli were applied as distensions with a bag using an impedance planimetric method. Distensions were done before and after pharmacological impairment of distension induced smooth muscle contractions. Thermal stimulation was performed by recirculating water at 1 and 60\u00b0C in the bag. The area under the temperature curve (AUC) represented caloric load. The referred pain area (being a proxy for the central pain mechanisms) to the mechanical stimuli was drawn at maximum pain intensities.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Patients were hyposensitive to mechanical stimuli, as assessed by the distending volume (F\u200a=\u200a8.1, p\u200a=\u200a0.005). After relaxation of smooth muscle with butylscopolamine, the difference between the two groups was more evident (F\u200a=\u200a27.4, p&lt;0.001). AUC for cold stimulation was 1048.6 (242.7) \u00b0C\u00d7s in controls and 889.8 (202.6) \u00b0C\u00d7s in patients (p\u200a=\u200a0.5). For heat stimuli, AUC values were 323.3 (104.1) and 81.3 (32.3) \u00b0C\u00d7s in controls and patients, respectively (p\u200a=\u200a0.04). The referred pain area to the mechanical stimulations was larger and more widespread in patients (49.3 (6.2) cm\n                    <jats:sup>2<\/jats:sup>\n                    compared with controls 23.9 (7) cm\n                    <jats:sup>2<\/jats:sup>\n                    ; p\u200a=\u200a0.02).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The data indicate that peripheral sensitisation of heat sensitive receptors and pathways combined with facilitation of central pain mechanisms may explain the symptoms in patients with oesophagitis.\n                  <\/jats:p>","DOI":"10.1136\/gut.2005.067769","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T22:53:39Z","timestamp":1123628019000},"page":"926-932","source":"Crossref","is-referenced-by-count":56,"title":["Multimodal pain stimulations in patients with grade B oesophagitis"],"prefix":"10.1136","volume":"55","author":[{"given":"A M","family":"Drewes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Funch-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Arendt-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,8,9]]},"reference":[{"key":"2025112109574556000_55.7.926.1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.0953-0673.2003.01725.x","volume":"18","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"2025112109574556000_55.7.926.2","first-page":"A77","volume":"110","year":"1996","journal-title":"Gastroenterol"},{"key":"2025112109574556000_55.7.926.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.885"},{"key":"2025112109574556000_55.7.926.4","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000007857.15694.15"},{"key":"2025112109574556000_55.7.926.5","doi-asserted-by":"publisher","DOI":"10.1080\/003655298750026697"},{"key":"2025112109574556000_55.7.926.6","first-page":"S31","volume":"98","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"2025112109574556000_55.7.926.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30124.x"},{"key":"2025112109574556000_55.7.926.8","unstructured":"Sengupta JN, Gebhart GF. 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