{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:20:42Z","timestamp":1791030042179,"version":"4.1.0"},"reference-count":45,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background and aim:<\/jats:bold>\n                    1.4-Dihydroxy-2-naphthoic acid (DHNA), a bifidogenic growth stimulator from\n                    <jats:italic>Propionibacterium freudenreichii<\/jats:italic>\n                    , is thought to have a beneficial effect as a prebiotic; however, its in vivo effect on intestinal inflammation remains unknown. The aim of this study was to determine whether oral administration of DHNA can ameliorate dextran sodium sulphate (DSS) induced colitis and to determine the possible underlying mechanisms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Method:<\/jats:bold>\n                    Colitis was induced in mice by treatment with 2.0% DSS for seven days. DHNA (0.6 or 2.0 mg\/kg) was given in drinking water prior to (preventive study) or after (therapeutic study) DSS administration. Colonic damage was histologically scored, and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expression and \u03b27 positive cell infiltration were determined by immunohistochemistry. mRNA levels of proinflammatory cytokines (interleukin (IL)-1\u03b2, IL-6 and tumour necrosis factor \u03b1 (TNF-\u03b1)) were determined by quantitative real time polymerase chain reaction. In addition, bacterial flora in the caecum, concentrations of short chain acids, and luminal pH were examined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    DHNA improved survival rate and histological damage score in mice administered DSS in both the preventive and therapeutic studies. DHNA significantly attenuated the enhanced expression of MAdCAM-1, the increased \u03b27 positive cell number, and the increased mRNA levels of IL-1\u03b2, IL-6, and TNF-\u03b1 in DSS treated colon. In addition, the decreased number of\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    induced by DSS was recovered by DHNA. Preventive effects on decrease in butyrate concentration and decrease in pH level in mice administered DSS were also observed in the DHNA preventive study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    DHNA, a novel type of prebiotic, attenuates colonic inflammation not only by balancing intestinal bacterial flora but also by suppressing lymphocyte infiltration through reduction of MAdCAM-1.\n                  <\/jats:p>","DOI":"10.1136\/gut.2005.070490","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T20:23:56Z","timestamp":1132345436000},"page":"681-688","source":"Crossref","is-referenced-by-count":70,"title":["<i>Propionibacterium freudenreichii<\/i>\n                    component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing"],"prefix":"10.1136","volume":"55","author":[{"given":"Y","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tsuzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Matsuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Hokari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Komoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"2025120601021672000_55.5.681.1","first-page":"5S","volume":"92","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025120601021672000_55.5.681.2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80068-P"},{"key":"2025120601021672000_55.5.681.3","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1128\/IAI.66.11.5224-5231.1998","volume":"66","year":"1998","journal-title":"Infect Immun"},{"key":"2025120601021672000_55.5.681.4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.6.2359"},{"key":"2025120601021672000_55.5.681.5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118878"},{"key":"2025120601021672000_55.5.681.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70535-9"},{"key":"2025120601021672000_55.5.681.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70013-2"},{"key":"2025120601021672000_55.5.681.8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01211184","volume":"31","year":"1996","journal-title":"J Gastroenterol"},{"key":"2025120601021672000_55.5.681.9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1572-0241.1999.872_a.x","volume":"94","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"2025120601021672000_55.5.681.10","doi-asserted-by":"publisher","DOI":"10.1159\/000051913"},{"key":"2025120601021672000_55.5.681.11","doi-asserted-by":"crossref","first-page":"415S","DOI":"10.1093\/ajcn\/73.2.415s","volume":"73","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"2025120601021672000_55.5.681.12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.024"},{"key":"2025120601021672000_55.5.681.13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01038.x"},{"key":"2025120601021672000_55.5.681.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.02025.x"},{"key":"2025120601021672000_55.5.681.15","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20031031"},{"key":"2025120601021672000_55.5.681.16","first-page":"77","volume":"69","year":"1993","journal-title":"Lab Invest"},{"key":"2025120601021672000_55.5.681.17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00026.2002"},{"key":"2025120601021672000_55.5.681.18","doi-asserted-by":"publisher","DOI":"10.1038\/331041a0"},{"key":"2025120601021672000_55.5.681.19","doi-asserted-by":"publisher","DOI":"10.1038\/363461a0"},{"key":"2025120601021672000_55.5.681.20","first-page":"97","volume":"151","year":"1997","journal-title":"Am J Pathol"},{"key":"2025120601021672000_55.5.681.21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2463"},{"key":"2025120601021672000_55.5.681.22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-3565(24)38885-8","volume":"295","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"2025120601021672000_55.5.681.23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01690.x"},{"key":"2025120601021672000_55.5.681.24","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.66.679"},{"key":"2025120601021672000_55.5.681.25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/np50025a002","volume":"46","year":"1983","journal-title":"J Nat Prod"},{"key":"2025120601021672000_55.5.681.26","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90599-5"},{"key":"2025120601021672000_55.5.681.27","first-page":"238","volume":"69","year":"1993","journal-title":"Lab Invest"},{"key":"2025120601021672000_55.5.681.28","first-page":"219","volume":"234","year":"1976","journal-title":"Zentralbl Bakteriol [Orig A]"},{"key":"2025120601021672000_55.5.681.29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/jn\/124.1.52","volume":"124","year":"1994","journal-title":"J Nutr"},{"key":"2025120601021672000_55.5.681.30","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90305-A"},{"key":"2025120601021672000_55.5.681.31","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.6.856"},{"key":"2025120601021672000_55.5.681.32","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.7.933"},{"key":"2025120601021672000_55.5.681.33","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.4049\/jimmunol.151.10.5239","volume":"151","year":"1993","journal-title":"J Immunol"},{"key":"2025120601021672000_55.5.681.34","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80005-9"},{"key":"2025120601021672000_55.5.681.35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00467.2004"},{"key":"2025120601021672000_55.5.681.36","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/0016-5085(92)91182-4","volume":"103","year":"1992","journal-title":"Gastroenterology"},{"key":"2025120601021672000_55.5.681.37","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.01.012"},{"key":"2025120601021672000_55.5.681.38","doi-asserted-by":"crossref","unstructured":"Hoentjen FZX, Tannock GW, Dieleman LA. The prebiotic combination inulin and oligofructose prevents colitis in HLA-B27 transgenic rats. Can J Gastroenterol. 2004;18: (suppl A),.","DOI":"10.1097\/00042737-200601000-00102"},{"key":"2025120601021672000_55.5.681.39","unstructured":"Keusch GTGS. Enteric microbial ecology and infection, part 1 bacteria. In: Haubrich WS, Schaffner F, Berk JE, eds. Bockus gastroenterology, vol 2, 5th Edn. Philadelphia: Saunders, 1995:1115\u20131130."},{"key":"2025120601021672000_55.5.681.40","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/ajcn\/30.11.1799","volume":"30","year":"1977","journal-title":"Am J Clin Nutr"},{"key":"2025120601021672000_55.5.681.41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05613.x"},{"key":"2025120601021672000_55.5.681.42","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19870073"},{"key":"2025120601021672000_55.5.681.43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0016-5085(82)80339-9","volume":"83","year":"1982","journal-title":"Gastroenterology"},{"key":"2025120601021672000_55.5.681.44","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1046\/j.1440-1746.2002.02709.x","volume":"17","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"2025120601021672000_55.5.681.45","doi-asserted-by":"publisher","DOI":"10.1007\/s005350300022"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2005.070490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T09:02:26Z","timestamp":1765011746000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2005.070490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,18]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2006,4,11]]},"published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1136\/gut.2005.070490"],"URL":"https:\/\/doi.org\/10.1136\/gut.2005.070490","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,18]]}}}