{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:05:00Z","timestamp":1790910300064,"version":"4.1.0"},"reference-count":52,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2006,3,16]]},"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background and aims:<\/jats:bold>\n                    Oesophageal adenocarcinoma frequently develops on a background of metaplastic Barrett\u2019s epithelium. The development of malignancy is accompanied by genetic alterations, which may be promising biomarkers of disease progression.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A case control study was conducted nested within a large unselected population based cohort of Barrett\u2019s patients. Incident oesophageal malignancies and high grade dysplasias were identified. For each case up to five controls were matched on age, sex, and year of diagnosis. Biopsies from the time of diagnosis of Barrett\u2019s epithelium were stained immunohistochemically for TP53, cyclin D1, cyclooxygenase 2 (COX-2), and \u03b2-catenin proteins.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Twenty nine incident oesophageal malignancies and six cases of high grade dysplasia were identified. The odds of diffuse or intense TP53 staining were substantially elevated in biopsies from patients who developed oesophageal adenocarcinoma compared with controls (odds ratio (OR) 11.7 (95% confidence interval (CI) 1.93, 71.4)). This difference was also present when all cases were considered (OR 8.42 (95% CI 2.37, 30.0). Despite the association with TP53 staining, only 32.4% of cases had an initial biopsy showing diffuse\/intense TP53 staining. There were no significant associations between cyclin D1, COX-2, or \u03b2-catenin staining and case control status. The OR for positive staining for both TP53 and COX-2 was markedly increased in cases compared with controls (OR 27.3 (95% CI 2.89, 257.0)) although only 15% of cases had positive staining for both markers.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Immunohistochemical detection of TP53 expression is a biomarker of malignant progression in Barrett\u2019s oesophagus but sensitivity is too low to act as a criterion to inform endoscopic surveillance strategies. Additional biomarkers are required which when combined with TP53 will identify, with adequate sensitivity and specificity, Barrett\u2019s patients who are at risk of developing cancer.\n                  <\/jats:p>","DOI":"10.1136\/gut.2005.083295","type":"journal-article","created":{"date-parts":[[2006,5,8]],"date-time":"2006-05-08T21:40:08Z","timestamp":1147124408000},"page":"1390-1397","source":"Crossref","is-referenced-by-count":102,"title":["TP53 and progression from Barrett\u2019s metaplasia to oesophageal adenocarcinoma in a UK population cohort"],"prefix":"10.1136","volume":"55","author":[{"given":"L","family":"Murray","sequence":"first","affiliation":[{"name":"Centre for Clinical and Population Sciences, The Queen\u2019s University of Belfast, Mulhouse Building, The Royal Group of Hospitals, Belfast, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sedo","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Unit, Centre for 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