{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:35:30Z","timestamp":1791279330396,"version":"4.1.0"},"reference-count":41,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Visceral hypersensitivity is an important pathophysiological factor in irritable bowel syndrome (IBS). Pre-clinical studies suggest that the \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u03b4 ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To assess the effect of pregabalin on the perception of rectal distension in hypersensitive IBS patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty-six patients with Rome-II-defined IBS (aged 18\u201346 years, 7 male) were included in a randomized, double-blind, placebo-controlled, parallel-group study in which they received either 3 weeks oral pregabalin (titrated: 50 mg tid days 1\u20133, 100 mg tid days 4\u20137, 150 mg tid days 8\u201311; fixed 200 mg tid days 12\u201321 \u00b14) or placebo control. Rectal sensitivity was assessed using a barostat technique, in which sensory thresholds were determined using the ascending method of limits, followed by tracking both before and after treatment. Only patients with a pain threshold of \u2a7d28 mmHg were included in the study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Pregabalin significantly increased the sensory thresholds from baseline for first sensation (p\u200a=\u200a0.045), desire to defecate (p\u200a=\u200a0.008) and pain (p\u200a=\u200a0.048) compared with placebo control. In addition, pregabalin significantly increased rectal compliance (p&lt;0.0001), although this appeared to be unrelated to the changes in sensitivity. Despite the occurrence of mild dizziness and somnolence, pregabalin was generally well tolerated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Pregabalin increased distension sensory thresholds to normal levels in IBS patients with rectal hypersensitivity. A concomitant increase in rectal compliance appeared to be unrelated to the reduction in sensitivity. These data suggest that \u03b1\n                    <jats:sub>2<\/jats:sub>\n                    \u03b4 ligands are worthy of further investigation in the treatment of visceral pain disorders, including IBS.\n                  <\/jats:p>","DOI":"10.1136\/gut.2006.110858","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T20:38:28Z","timestamp":1177015108000},"page":"1218-1225","source":"Crossref","is-referenced-by-count":180,"title":["Effect of a second-generation \u03b1\n                    <sub>2<\/sub>\n                    \u03b4 ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome"],"prefix":"10.1136","volume":"56","author":[{"given":"L A","family":"Houghton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Whorwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Sudworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J D","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,4,19]]},"reference":[{"key":"2025112109453644000_56.9.1218.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.2.125"},{"key":"2025112109453644000_56.9.1218.2","unstructured":"Houghton L A. 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