{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:00:51Z","timestamp":1791126051803,"version":"4.1.0"},"reference-count":41,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2007,10,23]]},"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Infection with the hepatitis C virus (HCV) causes acute hepatitis. This disease has a high probability of becoming chronic and leading to cirrhosis, but a more deadly consequence is hepatocellular carcinoma. Interferon \u03b1 (IFN\u03b1)-based treatment combined with ribavirin is the major therapeutic choice available for the treatment of chronic HCV infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims:<\/jats:title>\n                  <jats:p>The scavenger receptor class B type I (SR-BI) or its human homologue CD36 and LIMPII Analogous-1 (hSR-BI\/CLA-1) has recently been shown to interact with HCV envelope glycoprotein E2, thus suggesting that it might participate in entry of the virus into host cells. This rationale underlies current interest in the potential role of IFN\u03b1 in hSR-BI\/CLA-1 expression in HepG2 cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>It was shown that endogenous hepatocyte expression of hSR-BI\/CLA-1 was suppressed by exposure to IFN\u03b1. Decreased hSR-BI\/CLA-1 expression in IFN\u03b1-treated cells was due to lower transcriptional activity of the promoter. A potential pathway for the effect of IFN\u03b1 on hSR-BI\/CLA-1 promoter activity was identified when the inhibitory action of IFN was abrogated in signal transducer and activator of transcription 1 (STAT1)\/STAT2 knocked-down cells. Exposure of HepG2 cells to IFN\u03b1 elicited a rapid phosphorylation of STAT1\/STAT2, a known target of IFN\u03b1 signalling. In addition, the mutagenesis of a STAT1\/STAT2 response element in the hSR-BI\/CLA-1 promoter abolished the ability of IFN\u03b1 to suppress promoter activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Together, these results indicate that the STAT1\/STAT2 pathway participates in IFN\u03b1 inhibtion of hSR-BI\/CLA-1 expression, and raise the possibility that lowering the expression of this gene may be of therapeutic value for treating HCV infections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/gut.2006.111443","type":"journal-article","created":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T21:05:55Z","timestamp":1194901555000},"page":"664-671","source":"Crossref","is-referenced-by-count":26,"title":["Interferon \u03b1 decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes"],"prefix":"10.1136","volume":"57","author":[{"given":"K","family":"Murao","sequence":"first","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Imachi","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Yu","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W M","family":"Cao","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Nishiuchi","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Chen","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Li","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A M","family":"Ahmed","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N C W","family":"Wong","sequence":"additional","affiliation":[{"name":"2 Departments of Medicine and Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Health Sciences Center, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ishida","sequence":"additional","affiliation":[{"name":"1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,11,12]]},"reference":[{"key":"2025090800031362000_57.5.664.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450107"},{"key":"2025090800031362000_57.5.664.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-4-200002150-00008"},{"key":"2025090800031362000_57.5.664.3","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00077-7"},{"key":"2025090800031362000_57.5.664.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81289-1"},{"key":"2025090800031362000_57.5.664.5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405695101"},{"key":"2025090800031362000_57.5.664.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5390.938"},{"key":"2025090800031362000_57.5.664.7","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf529"},{"key":"2025090800031362000_57.5.664.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12766"},{"key":"2025090800031362000_57.5.664.9","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.546-559.2003"},{"key":"2025090800031362000_57.5.664.10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305289200"},{"key":"2025090800031362000_57.5.664.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402253101"},{"key":"2025090800031362000_57.5.664.12","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.518"},{"key":"2025090800031362000_57.5.664.13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.28.17551"},{"key":"2025090800031362000_57.5.664.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90061-6"},{"key":"2025090800031362000_57.5.664.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000067429.46333.7B"},{"key":"2025090800031362000_57.5.664.16","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0330"},{"key":"2025090800031362000_57.5.664.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.131"},{"key":"2025090800031362000_57.5.664.18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1507\/endocrj.46.27","article-title":"Evidence for a potential role for HDL as an important source of cholesterol in human adrenocortical tumors via the CLA-1 pathway.","volume":"46","author":"Imachi","year":"1999","journal-title":"Endocr J"},{"key":"2025090800031362000_57.5.664.19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/labinvest.3780029","article-title":"Human scavenger receptor B1 is involved in recognition of apoptotic thymocytes by thymic nurse cells.","volume":"80","author":"Imachi","year":"2000","journal-title":"Lab Invest"},{"key":"2025090800031362000_57.5.664.20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411600200"},{"key":"2025090800031362000_57.5.664.21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.10.3252"},{"key":"2025090800031362000_57.5.664.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.52.33068"},{"key":"2025090800031362000_57.5.664.23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.30.18959"},{"key":"2025090800031362000_57.5.664.24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0168-8278(01)00262-8","article-title":"Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells.","volume":"36","author":"Garcia","year":"2002","journal-title":"J Hepatol"},{"key":"2025090800031362000_57.5.664.25","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1055\/s-0028-1093713","article-title":"Radioimmunoassay of arginine vasopressin in human plasma.","volume":"7","author":"Uhlich","year":"1975","journal-title":"Horm Metab Res"},{"key":"2025090800031362000_57.5.664.26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.24.15241"},{"key":"2025090800031362000_57.5.664.27","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90105-L"},{"key":"2025090800031362000_57.5.664.28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094823"},{"key":"2025090800031362000_57.5.664.29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.446"},{"key":"2025090800031362000_57.5.664.30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0831128100"},{"key":"2025090800031362000_57.5.664.31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302267200"},{"key":"2025090800031362000_57.5.664.32","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02356-06"},{"key":"2025090800031362000_57.5.664.33","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0376"},{"key":"2025090800031362000_57.5.664.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2004.08.004"},{"key":"2025090800031362000_57.5.664.35","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0022-2275(20)37431-9","article-title":"Alternative forms of the scavenger receptor BI (SR-BI).","volume":"38","author":"Webb","year":"1997","journal-title":"J Lipid Res"},{"key":"2025090800031362000_57.5.664.36","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.006"},{"key":"2025090800031362000_57.5.664.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.081"},{"key":"2025090800031362000_57.5.664.38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215770"},{"key":"2025090800031362000_57.5.664.39","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.778-809.2001"},{"key":"2025090800031362000_57.5.664.40","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1128\/MCB.16.12.6937","article-title":"Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons.","volume":"16","author":"Meinke","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2025090800031362000_57.5.664.41","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2004.37.6.635"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2006.111443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T07:03:24Z","timestamp":1757315004000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2006.111443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,12]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,4,11]]},"published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1136\/gut.2006.111443"],"URL":"https:\/\/doi.org\/10.1136\/gut.2006.111443","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,12]]}}}