{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:30:13Z","timestamp":1792294213573,"version":"4.4.0"},"reference-count":33,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The relationship between appendectomy and Crohn\u2019s disease is controversial. A Swedish\u2013Danish cohort study was conducted to assess the risk of developing Crohn\u2019s disease after an appendectomy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    709 353 appendectomy patients in Sweden (since 1964) and Denmark (since 1977) were followed for first hospitalisations for Crohn\u2019s disease to 2004. Standardised incidence ratios (SIR) served as relative risks.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Overall, 1655 Crohn\u2019s disease cases were observed during 11.1 million person-years of follow-up. Whereas appendectomy before the age of 10 years was not associated with the risk of Crohn\u2019s disease (SIR 1.00; 95% CI 0.80\u20131.25), the overall SIR of developing Crohn\u2019s disease was 1.52 (95% CI 1.45\u20131.59), being highest in the first 6\u200amonths (SIR 8.69; 95% CI 7.68\u20139.84). SIR diminished rapidly thereafter, with the risk of Crohn\u2019s disease reaching background levels after 5\u201310 years for Crohn\u2019s disease overall, as well as for Crohn\u2019s ileitis, ileocolonic Crohn\u2019s disease, Crohn\u2019s colitis and other\/unspecified Crohn\u2019s disease. A long-term increased risk of Crohn\u2019s disease up to 20 years after the appendectomy was seen only in appendectomy patients without appendicitis or mesenteric lymphadenitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The transient increased risk of Crohn\u2019s disease after an appendectomy is probably explained by diagnostic bias.\n                  <\/jats:p>","DOI":"10.1136\/gut.2007.121467","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T20:44:49Z","timestamp":1178743489000},"page":"1387-1392","source":"Crossref","is-referenced-by-count":78,"title":["The risk of developing Crohn\u2019s disease after an appendectomy: a population-based cohort study in Sweden and Denmark"],"prefix":"10.1136","volume":"56","author":[{"given":"Gilaad G","family":"Kaplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo 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