{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:32:36Z","timestamp":1773869556764,"version":"3.50.1"},"reference-count":34,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>\n                  <jats:bold>Background and aims:<\/jats:bold> There is a need for genetic biomarkers to guide prognosis and management of gastric mucosa-associated lymphoid tissue (MALT) lymphomas. We assessed the incidence and clinical significance of the MALT lymphoma-associated genetic abnormalities t(11;18)\/<jats:italic>API2-MALT1<\/jats:italic>, t(1;14)\/<jats:italic>BCL10-IGH<\/jats:italic>, t(14;18)\/<jats:italic>IGH-MALT1<\/jats:italic>, t(3;14)\/<jats:italic>FOXP1-IGH<\/jats:italic>, and extra copies of <jats:italic>MALT1<\/jats:italic> and <jats:italic>FOXP1<\/jats:italic> in gastric MALT lymphomas from Japan.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> The presence of translocations and copy number changes involving <jats:italic>MALT1<\/jats:italic>, <jats:italic>IGH<\/jats:italic> and <jats:italic>FOXP1<\/jats:italic> were assessed in 90 cases of gastric MALT lymphoma using interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridisation (FISH). In cases carrying a <jats:italic>MALT1<\/jats:italic> translocation, FISH for <jats:italic>API2-MALT1<\/jats:italic> was performed, whereas in those carrying an <jats:italic>IGH<\/jats:italic> translocation, FISH was performed for <jats:italic>BCL10<\/jats:italic>, <jats:italic>BCL6<\/jats:italic>, <jats:italic>BCL2<\/jats:italic>, <jats:italic>c-MYC<\/jats:italic> and\/or <jats:italic>CCND1<\/jats:italic>.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> t(11;18)\/<jats:italic>API2-MALT1<\/jats:italic> was detected in 18 of 87 (21%) cases and was significantly associated with <jats:italic>Helicobacter pylori<\/jats:italic>-negativity, resistance to <jats:italic>H pylori<\/jats:italic> eradication and Bcl10 nuclear expression. Four of 68 (6%) cases carried a translocation involving <jats:italic>IGH<\/jats:italic> and <jats:italic>FOXP1<\/jats:italic> (n\u200a=\u200a1), <jats:italic>BCL2<\/jats:italic> (n\u200a=\u200a1) or an unknown partner (n\u200a=\u200a2). Neither t(1;14)\/<jats:italic>BCL10-IGH<\/jats:italic> nor t(14;18)\/<jats:italic>IGH-MALT1<\/jats:italic> was detected. Extra copies of <jats:italic>MALT1<\/jats:italic> and <jats:italic>FOXP1<\/jats:italic> were detected in 18 of 71 (25%) cases and 10 of 59 (17%) cases, respectively. The presence of extra copies of <jats:italic>MALT1<\/jats:italic> was significantly associated with progression or relapse of lymphoma, and was an independent adverse prognostic factor for event-free survival as determined by multivariate analysis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> t(11;18)\/<jats:italic>API2-MALT1<\/jats:italic> is frequent, whereas <jats:italic>IGH<\/jats:italic>-involved translocations are rare in gastric MALT lymphoma in Japan. The presence of extra copies of <jats:italic>MALT1<\/jats:italic>, often suggestive of partial or complete trisomy 18, is a frequent genetic aberration in gastric MALT lymphoma, which appears to predict adverse clinical behaviour.<\/jats:p>","DOI":"10.1136\/gut.2007.123729","type":"journal-article","created":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T20:40:40Z","timestamp":1180039240000},"page":"1358-1363","source":"Crossref","is-referenced-by-count":80,"title":["Clinical impact of genetic aberrations in gastric MALT lymphoma: a comprehensive analysis using interphase fluorescence <i>in situ<\/i> hybridisation"],"prefix":"10.1136","volume":"56","author":[{"given":"Shotaro","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris M","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Goatly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison H","family":"Banham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Ohji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masazumi","family":"Tsuneyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Qing","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2007,5,24]]},"reference":[{"key":"2025090723065149000_56.10.1358.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1409"},{"key":"2025090723065149000_56.10.1358.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061663"},{"key":"2025090723065149000_56.10.1358.3","doi-asserted-by":"crossref","unstructured":"Hu H, Wang B, Borde M. et al Foxp1 is an essential transcriptional regulator of B cell development. 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