{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:49:30Z","timestamp":1791258570359,"version":"4.1.0"},"reference-count":47,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Colonoscopic surveillance for hereditary non-polyposis colorectal cancer (HNPCC) reduces death rates, but early interval cancers still occur, probably due to missed small, aggressive adenomas. Narrow band imaging (NBI), a novel endoscopic technology, highlights superficial mucosal capillaries and improves contrast for adenomas. This study examined whether a second pass with NBI in the proximal colon helped detect additional adenomas in patients with HNPCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>62 patients from HNPCC families (Amsterdam II or genetic criteria) attending for colonoscopic surveillance were examined twice from caecum to sigmoid\u2013descending junction, first with high definition white light and then a second pass with NBI in a back-to-back fashion. All polyps detected were removed for histopathological analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At least one adenoma in the proximal colon was detected during the initial white light pass in 17\/62 (27%). NBI detected additional adenomas in 17\/62 (27%). 26\/62 (42%) patients had at least one adenoma detected after both white light and NBI; absolute difference 15% (95% CI 4\u201325%), p\u200a=\u200a0.004 versus white light alone. The total number of adenomas increased from 25 before NBI to 46 after NBI examination, p&lt;0.001. The proportion of flat adenomas detected in the NBI pass, 9\/21 (45%), was higher than in the white light pass, 3\/25 (12%), p\u200a=\u200a0.03. Including white light examination of the sigmoid and rectum, overall 28\/62 (45%) patients had at least one adenoma detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Use of NBI in the proximal colon for patients undergoing HNPCC surveillance appears to improve adenoma detection, particularly those with a flat morphology. NBI could help reduce interval cancer rates. ClinicalTrials.gov Identifier:NCT00313755.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2007.128926","type":"journal-article","created":{"date-parts":[[2007,8,6]],"date-time":"2007-08-06T20:41:15Z","timestamp":1186432875000},"page":"65-70","source":"Crossref","is-referenced-by-count":153,"title":["Narrow band imaging for colonoscopic surveillance in hereditary non-polyposis colorectal cancer"],"prefix":"10.1136","volume":"57","author":[{"given":"J E","family":"East","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stavrinidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Guenther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H J W","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B P","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,8,6]]},"reference":[{"key":"2025121223063838000_57.1.65.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012242"},{"key":"2025121223063838000_57.1.65.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70168-5"},{"key":"2025121223063838000_57.1.65.3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.1.21"},{"key":"2025121223063838000_57.1.65.4","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50044"},{"key":"2025121223063838000_57.1.65.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38606.794560.EB"},{"key":"2025121223063838000_57.1.65.6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.032"},{"key":"2025121223063838000_57.1.65.7","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90688-6"},{"key":"2025121223063838000_57.1.65.8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.3.382"},{"key":"2025121223063838000_57.1.65.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00390.x"},{"key":"2025121223063838000_57.1.65.10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925265"},{"key":"2025121223063838000_57.1.65.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.12.009"},{"key":"2025121223063838000_57.1.65.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70034-5"},{"key":"2025121223063838000_57.1.65.13","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.029868"},{"key":"2025121223063838000_57.1.65.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41481.x"},{"key":"2025121223063838000_57.1.65.15","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00403-9"},{"key":"2025121223063838000_57.1.65.16","doi-asserted-by":"publisher","DOI":"10.1117\/1.1695563"},{"key":"2025121223063838000_57.1.65.17","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1809"},{"key":"2025121223063838000_57.1.65.18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-826040"},{"key":"2025121223063838000_57.1.65.19","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.11.989"},{"key":"2025121223063838000_57.1.65.20","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870433"},{"key":"2025121223063838000_57.1.65.21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-825961"},{"key":"2025121223063838000_57.1.65.22","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000204304.38797.34"},{"key":"2025121223063838000_57.1.65.23","unstructured":"Bryan R Billingham L Wallace M . 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