{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:40:23Z","timestamp":1773085223917,"version":"3.50.1"},"reference-count":33,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Hyperdynamic circulation in portal hypertensive rats depends on central neural c-\n                      <jats:italic>fos<\/jats:italic>\n                      gene expression, but how the portal hypertensive signal activates central c-\n                      <jats:italic>fos<\/jats:italic>\n                      expression remains obscure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To elucidate the afferent pathway from the gut to the central cardiovascular regulatory nuclei in portal hypertensive rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Cervical vagus nerves and the coeliac ganglion were treated with topical capsaicin to denervate the sensory afferents. Surgical portal vein stenosis (PVS) was performed 3 weeks after denervation. Effectiveness of vagal afferent denervation was confirmed by absent oesophagus to brainstem transfer of the neural tracer cholera toxin-conjugated horseradish peroxidase. Fos, the protein product of the c-\n                      <jats:italic>fos<\/jats:italic>\n                      gene, was detected by immunohistochemistry in central cardiovascular regulatory nuclei. Vagal nerve activity was measured after acute portal hypertension induced by an inflatable cuff around the portal vein. Cardiac output and mean arterial pressure were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In vagal capsaicin-treated rats, no horseradish peroxidase was detected in the brainstem after oesophageal injection. In vagal capsaicin-treated rats subjected to PVS, Fos expression was significantly decreased in both the solitary tract nucleus and paraventricular nucleus compared with untreated PVS rats. Acute portal hypertension stimulated vagal nerve electrical activity. The hyperdynamic circulation was completely abrogated in vagal capsaicin-treated PVS rats. Capsaicin induced no neural or haemodynamic changes in either sham-operated controls or coeliac ganglion-treated PVS rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In portal hypertensive rats, central cardiovascular regulatory nuclei initiate hyperdynamic circulation in response to a gut signal associated with portal hypertension. Portal hypertension signals to the central nuclei via capsaicin-sensitive vagal afferent nerves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2007.135020","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T20:44:21Z","timestamp":1202849061000},"page":"966-973","source":"Crossref","is-referenced-by-count":33,"title":["Central neural activation of hyperdynamic circulation in portal hypertensive rats depends on vagal afferent nerves"],"prefix":"10.1136","volume":"57","author":[{"given":"H","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Schuelert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"McDougall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,2,12]]},"reference":[{"key":"2025120601065936000_57.7.966.1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1172\/JCI102813","article-title":"The cardiac output at rest in Laennec\u2019s cirrhosis.","volume":"32","author":"Kowalski","year":"1953","journal-title":"J Clin Invest"},{"key":"2025120601065936000_57.7.966.2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2362.1982.tb02240.x","article-title":"Changes in splanchnic blood flow in portal hypertensive rats.","volume":"12","author":"Blanchet","year":"1982","journal-title":"Eur J Clin Invest"},{"key":"2025120601065936000_57.7.966.3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20993"},{"key":"2025120601065936000_57.7.966.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01163.x"},{"key":"2025120601065936000_57.7.966.5","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.30417"},{"key":"2025120601065936000_57.7.966.6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00526-V"},{"key":"2025120601065936000_57.7.966.7","doi-asserted-by":"publisher","DOI":"10.1007\/s002100000359"},{"key":"2025120601065936000_57.7.966.8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260601"},{"key":"2025120601065936000_57.7.966.9","unstructured":"Paxino G WC . 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