{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:48:30Z","timestamp":1792705710908,"version":"4.5.0"},"reference-count":43,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Endoscopic therapy is increasingly being used in the treatment of high-grade intraepithelial neoplasia (HGIN) and mucosal adenocarcinoma (BC) in patients with Barrett\u2019s oesophagus. This report provides 5 year follow-up data from a large prospective study investigating the efficacy and safety of endoscopic treatment in these patients and analysing risk factors for recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Prospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Academic tertiary care centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Between October 1996 and September 2002, 61 patients with HGIN and 288 with BC were included (173 with short-segment and 176 with long-segment Barrett\u2019s oesophagus) from a total of 486 patients presenting with Barrett\u2019s neoplasia. Patients with submucosal or more advanced cancer were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions:<\/jats:title>\n                    <jats:p>Endoscopic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures:<\/jats:title>\n                    <jats:p>Rate of complete remission and recurrence rate, tumour-associated death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Endoscopic resection was performed in 279 patients, photodynamic therapy in 55, and both procedures in 13; two patients received argon plasma coagulation. The mean follow-up period was 63.6 (SD 23.1) months. Complete response (CR) was achieved in 337 patients (96.6%); surgery was necessary in 13 (3.7%) after endoscopic therapy failed. Metachronous lesions developed during the follow-up in 74 patients (21.5%); 56 died of concomitant disease, but none died of BC. The calculated 5 year survival rate was 84%. The risk factors most frequently associated with recurrence were piecemeal resection, long-segment Barrett\u2019s oesophagus, no ablative therapy of Barrett\u2019s oesophagus after CR, time until CR achieved &gt;10 months and multifocal neoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study showed that endoscopic therapy was highly effective and safe, with an excellent long-term survival rate. The risk factors identified may help stratify patients who are at risk for recurrence and those requiring more intensified follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2007.142539","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T22:44:23Z","timestamp":1210113863000},"page":"1200-1206","source":"Crossref","is-referenced-by-count":566,"title":["Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett\u2019s oesophagus"],"prefix":"10.1136","volume":"57","author":[{"given":"O","family":"Pech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Nachbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gossner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Rabenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Manner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Guenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Huijsmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,5,6]]},"reference":[{"key":"2025112109080317000_57.9.1200.1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji024"},{"key":"2025112109080317000_57.9.1200.2","first-page":"1669","article-title":"Predictors of progression to cancer in Barrett\u00e2\u0080\u0099s esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets.","volume":"95","author":"Reid","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"2025112109080317000_57.9.1200.3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25065"},{"key":"2025112109080317000_57.9.1200.4","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25111"},{"key":"2025112109080317000_57.9.1200.5","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4591"},{"key":"2025112109080317000_57.9.1200.6","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200509000-00010"},{"key":"2025112109080317000_57.9.1200.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02017-6"},{"key":"2025112109080317000_57.9.1200.8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/01.sla.0000184211.75970.85","article-title":"Early esophageal squamous cell and adenocarcinoma: pattern of lymphatic spread and prognostic factors for long term survival after surgical resection.","volume":"242","author":"Stein","year":"2005","journal-title":"Ann Surg"},{"key":"2025112109080317000_57.9.1200.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00718.x"},{"key":"2025112109080317000_57.9.1200.10","unstructured":"Hamilton SR Aaltonen LA , eds. 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