{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:55:24Z","timestamp":1793069724516,"version":"4.5.0"},"reference-count":38,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim:<\/jats:title>\n                    <jats:p>To detect precancerous dysplasia or asymptomatic cancer, patients suffering from inflammatory bowel disease often undergo colonoscopic surveillance based on American or British guidelines. It is recommended that surveillance is initiated after 8\u201310 years of extensive colitis, or after 15\u201320 years for left-sided disease. These starting points, however, are not based on solid scientific evidence. Our aim was to assess the time interval between onset of inflammatory bowel disease (IBD) and colorectal carcinoma (CRC), and subsequently evaluate how many patients developed cancer before their surveillance was recommended to commence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A nationwide automated pathology database (PALGA) was consulted to identify patients with IBD-associated colorectal carcinoma in seven university medical centres in The Netherlands between January 1990 and June 2006. Data were collected retrospectively from patient charts. Time intervals between onset of disease and cancer diagnosis were calculated in months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      149 patients were identified with confirmed diagnoses of IBD and CRC (ulcerative colitis n\u200a=\u200a89\/Crohn\u2019s disease n\u200a=\u200a59\/indeterminate colitis n\u200a=\u200a1). Taking\n                      <jats:italic>date of diagnosis<\/jats:italic>\n                      as the entry point, 22% of patients developed cancer before the 8 or 15 year starting points of surveillance, and 28% if surveillance was commenced 10 or 20 years after diagnosis for extensive or left-sided disease, respectively. Using\n                      <jats:italic>onset of symptoms<\/jats:italic>\n                      to calculate the time interval, 17\u201322% of patients would present with cancer prior to the surveillance starting points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results show that the diagnosis of colorectal cancer is delayed or missed in a substantial number of patients (17\u201328%) when conducting surveillance strictly according to formal guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2007.143453","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T20:45:11Z","timestamp":1205354711000},"page":"1246-1251","source":"Crossref","is-referenced-by-count":180,"title":["High frequency of early colorectal cancer in inflammatory bowel disease"],"prefix":"10.1136","volume":"57","author":[{"given":"M W M D","family":"Lutgens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F P","family":"Vleggaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E I","family":"Schipper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C F","family":"Stokkers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"van der Woude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Hommes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Dijkstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"van Bodegraven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Samsom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,3,12]]},"reference":[{"key":"2025120618240934000_57.9.1246.1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.526"},{"key":"2025120618240934000_57.9.1246.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00287.x"},{"key":"2025120618240934000_57.9.1246.3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00079.2004"},{"key":"2025120618240934000_57.9.1246.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.08.023"},{"key":"2025120618240934000_57.9.1246.5","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50044"},{"key":"2025120618240934000_57.9.1246.6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.suppl_5.v10"},{"key":"2025120618240934000_57.9.1246.7","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive.","volume":"29","author":"Casparie","year":"2007","journal-title":"Cellular Oncol"},{"key":"2025120618240934000_57.9.1246.8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341210"},{"key":"2025120618240934000_57.9.1246.9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-198101000-00002","article-title":"The risk of cancer following colectomy and ileorectal anastomosis for extensive mucosal ulcerative colitis.","volume":"193","author":"Grundfest","year":"1981","journal-title":"Ann Surg"},{"key":"2025120618240934000_57.9.1246.10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/bjs.1800651211","article-title":"Cancer of the rectum following colectomy and ileorectal anastomosis for ulcerative colitis.","volume":"65","author":"Baker","year":"1978","journal-title":"Br J Surg"},{"key":"2025120618240934000_57.9.1246.11","first-page":"41","article-title":"Carcinoma of the colon and rectum associated with chronic ulcerative colitis.","volume":"103","author":"Thorlakson","year":"1956","journal-title":"Surg Gynecol Obstet"},{"key":"2025120618240934000_57.9.1246.12","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90683-5"},{"key":"2025120618240934000_57.9.1246.13","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/0016-5085(88)90541-0","article-title":"Colorectal cancer in patients with ulcerative colitis. A population study in central Israel.","volume":"94","author":"Gilat","year":"1988","journal-title":"Gastroenterology"},{"key":"2025120618240934000_57.9.1246.14","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.7.800"},{"key":"2025120618240934000_57.9.1246.15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM199011013231802","article-title":"Ulcerative colitis and colorectal cancer. A population-based study.","volume":"323","author":"Ekbom","year":"1990","journal-title":"N Engl J Med"},{"key":"2025120618240934000_57.9.1246.16","first-page":"193","article-title":"Carcinoma of the colon and rectum in inflammatory disease of the intestine.","volume":"156","author":"Johnson","year":"1983","journal-title":"Surg Gynecol Obstet"},{"key":"2025120618240934000_57.9.1246.17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0016-5085(83)80224-8","article-title":"Assessment of colorectal cancer risk in patients with ulcerative colitis: experience from a private practice.","volume":"85","author":"Katzka","year":"1983","journal-title":"Gastroenterology"},{"key":"2025120618240934000_57.9.1246.18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.10.1261"},{"key":"2025120618240934000_57.9.1246.19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.1.43"},{"key":"2025120618240934000_57.9.1246.20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.23.6.490"},{"key":"2025120618240934000_57.9.1246.21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.5.1.15"},{"key":"2025120618240934000_57.9.1246.22","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.2.206"},{"key":"2025120618240934000_57.9.1246.23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0016-5085(79)90279-8","article-title":"Cancer in universal and left-sided ulcerative colitis: factors determining risk.","volume":"77","author":"Greenstein","year":"1979","journal-title":"Gastroenterology"},{"key":"2025120618240934000_57.9.1246.24","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/00000658-197812000-00018","article-title":"Cancer risk in extensive ulcerative colitis.","volume":"188","author":"Kewenter","year":"1978","journal-title":"Ann Surg"},{"key":"2025120618240934000_57.9.1246.25","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5501.1442"},{"key":"2025120618240934000_57.9.1246.26","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1445-2197.1961.tb03129.x","article-title":"Carcinoma of the colon complicating ulcerative colitis.","volume":"30","author":"Russell","year":"1961","journal-title":"Aust NZ J Surg"},{"key":"2025120618240934000_57.9.1246.27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0016-5085(19)35241-2","article-title":"Carcinoma and ulcerative colitis: prognosis.","volume":"39","author":"Bargen","year":"1960","journal-title":"Gastroenterology"},{"key":"2025120618240934000_57.9.1246.28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM197107012850103","article-title":"Cancer risk and life expectancy of children with ulcerative colitis.","volume":"285","author":"Devroede","year":"1971","journal-title":"N Engl J Med"},{"key":"2025120618240934000_57.9.1246.29","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0140-6736(64)92474-2","article-title":"The cancer risk in ulcerative colitis.","volume":"19","author":"MacDougall","year":"1964","journal-title":"Lancet"},{"key":"2025120618240934000_57.9.1246.30","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh275"},{"key":"2025120618240934000_57.9.1246.31","first-page":"917","article-title":"Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level.","volume":"10","author":"Samowitz","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025120618240934000_57.9.1246.32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41442.x"},{"key":"2025120618240934000_57.9.1246.33","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.010"},{"key":"2025120618240934000_57.9.1246.34","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24052"},{"key":"2025120618240934000_57.9.1246.35","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70077-0"},{"key":"2025120618240934000_57.9.1246.36","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2036.2000.00698.x","article-title":"Colorectal cancer prevention in ulcerative colitis: a case\u00e2\u0080\u0093control study.","volume":"14","author":"Eaden","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2025120618240934000_57.9.1246.37","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.028"},{"key":"2025120618240934000_57.9.1246.38","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.038505"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2007.143453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:24:18Z","timestamp":1765074258000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2007.143453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,12]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2008,8,21]]},"published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1136\/gut.2007.143453"],"URL":"https:\/\/doi.org\/10.1136\/gut.2007.143453","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1119285.576405","asserted-by":"object"}]},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,12]]}}}