{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:55:43Z","timestamp":1790862943622,"version":"4.1.0"},"reference-count":28,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2008,6,10]]},"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim:<\/jats:title>\n                    <jats:p>\n                      It has been demonstrated that polymorphisms within inflammation-related genes are associated with the risk of gastric carcinoma (GC) in people infected with\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      . Recently, polymorphisms in the gene encoding the interferon gamma receptor 1 (\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      ) were found to be associated with increased susceptibility to\n                      <jats:italic>H pylori<\/jats:italic>\n                      infection. We aimed to determine the association between polymorphisms in the\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      gene and development of chronic gastritis and GC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In a case\u2013control study including 733 controls, 213 patients with chronic gastritis and 393 patients with GC, the\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      \u2212611*G\/*A, \u221256*C\/*T, +1004*A\/*C and +1400*T\/*C polymorphisms were genotyped. A second independent case\u2013control study including 100 controls and 65 patients with GC was used for confirmation of the original results. The effect of the \u221256*C\/*T promoter polymorphism in the level of expression of the\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      gene was evaluated by an\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      \u221256*C\/*T allele specific luciferase reporter assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In patients with early onset GC (defined as being less than 40 years of age at the time of diagnosis) we found a significant over-representation of the\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      \u221256*T\/*T homozygous genotype with an odds ratio (OR) of 4.1 (95% confidence interval (CI) 1.6 to 10.6). This result was confirmed in a second independent case\u2013control study. In the luciferase reporter assay we observed a 10-fold increase (p&lt;0.001) in luciferase expression associated with the\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      \u221256*T allele.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Our results indicate that the\n                      <jats:italic>IFNGR1<\/jats:italic>\n                      \u221256C\/T polymorphism is a relevant host susceptibility factor for GC development. Our data also indicate that this genetic polymorphism is functionally relevant and may be related to the early development of GC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2007.143578","type":"journal-article","created":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T20:44:58Z","timestamp":1214945098000},"page":"1504-1508","source":"Crossref","is-referenced-by-count":49,"title":["The interferon gamma receptor 1 (\n                    <i>IFNGR1<\/i>\n                    ) \u221256C\/T gene polymorphism is associated with increased risk of early gastric carcinoma"],"prefix":"10.1136","volume":"57","author":[{"given":"P","family":"Canedo","sequence":"first","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"},{"name":"Faculty of Medicine, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Corso","sequence":"additional","affiliation":[{"name":"Department of Human Pathology and Oncology, Surgical Oncology Unit, University of Siena, Istituto Toscano Tumori, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Lunet","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Faculty of Medicine, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Suriano","sequence":"additional","affiliation":[{"name":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, 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