{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:16:25Z","timestamp":1790907385082,"version":"4.1.0"},"reference-count":40,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of this study was to compare the costs and cost-effectiveness (C\/E) of early hepatitis C virus (HCV) RNA testing (alternative-US recommendations) after occupational exposure to HCV with existing follow-up strategies: (1) French, anti-HCV antibodies and alanine transaminase (ALT) activity at months 1, 3 and 6; (2) European, monthly ALT activity for 4 months and anti-HCV antibodies at month 6; (3) and baseline-US, anti-HCV antibodies and ALT activity at month 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A decision tree simulated each strategy for 7300 healthcare workers (HCWs) exposed to HCV each year in France, taking into account the impact of early diagnosis on the response to antiviral treatment and the deterioration of HCW quality of life after exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>For a HCV transmission risk of 0.5% after exposure, the French strategy led to the highest costs\/person (\u20ac181.40) and the baseline-US strategy to the lowest (\u20ac126.60) (\u20ac178.50) for alternative-US). The shortest mean time to HCV infection diagnosis (1 month) and the lowest number of chronic hepatitis C (CHC) patients (1.9\/7300 HCWs exposed) was obtained with the alternative-US strategy (vs 6 months and 7.9 CHC, respectively with baseline-US). Compared with the alternative-US, the French strategy was associated with higher costs and lower utilities, and the European with a higher incremental C\/E ratio. Compared with the baseline-US strategy, the alternative-US strategy C\/E ratio was \u20ac2020 per quality-adjusted life year saved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In HCWs exposed to HCV, a strategy based on early HCV RNA testing shortens the period during which the HCW\u2019s wait for his HCV status, leads to lower risk of progression to CHC and is reasonably cost-effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2007.145516","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T20:45:06Z","timestamp":1222721106000},"page":"105-110","source":"Crossref","is-referenced-by-count":15,"title":["Costs and cost-effectiveness of different follow-up schedules for detection of occupational hepatitis C virus infection"],"prefix":"10.1136","volume":"58","author":[{"given":"S","family":"Deuffic-Burban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Abiteboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Lot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Branger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bouvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yazdanpanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2008,9,29]]},"reference":[{"key":"2025120618082163000_58.1.105.1","unstructured":"RAISIN. Surveillance des Accidents avec Exposition au Sang dans les \u00e9tablissements de sant\u00e9 fran\u00e7ais. R\u00e9sultats ann\u00e9e 2004: R\u00e9seau d\u2019Alerte, d\u2019Investigation et de Surveillance des Infections Nosocomiales (RAISIN). Saint-Maurice, France: RAISN, 2006."},{"key":"2025120618082163000_58.1.105.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20230"},{"key":"2025120618082163000_58.1.105.3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2807\/esm.10.10.00573-en","article-title":"European recommendations for the management of healthcare workers occupationally exposed to hepatitis B virus and hepatitis C virus.","volume":"10","author":"Puro","year":"2005","journal-title":"Euro Surveill"},{"key":"2025120618082163000_58.1.105.4","first-page":"1","volume":"2","author":"Circulaire DGS\/DH\/DRT N\u00b099\/680 du 8 d\u00e9cembre 1999 relative aux recommandations \u00e0 mettre en oeuvre devant un risque de transmission du VHB et du VHC par le sang et les liquides biologiques","year":"2000","journal-title":"Bull Epidemiol Hebd"},{"key":"2025120618082163000_58.1.105.5","first-page":"1","article-title":"Updated US Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis.","volume":"50","author":"US Public Health Service","year":"2001","journal-title":"MMWR Recomm Rep"},{"key":"2025120618082163000_58.1.105.6","doi-asserted-by":"publisher","DOI":"10.2307\/30148418"},{"key":"2025120618082163000_58.1.105.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)93064-3"},{"key":"2025120618082163000_58.1.105.8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0676.1996.tb00755.x","article-title":"A prospective study of hepatitis C virus infection after needlestick accidents.","volume":"16","author":"Arai","year":"1996","journal-title":"Liver"},{"key":"2025120618082163000_58.1.105.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.01564.x"},{"key":"2025120618082163000_58.1.105.10","first-page":"1678","article-title":"Lack of transmission of hepatitis C virus following needlestick accidents.","volume":"46","author":"Hasan","year":"1999","journal-title":"Hepatogastroenterology"},{"issue":"(Suppl 2)","key":"2025120618082163000_58.1.105.11","first-page":"22","article-title":"Risk of hepatitis C virus transmission following percutaneous exposure in healthcare workers.","volume":"31","author":"De Carli","year":"2003","journal-title":"Infection"},{"key":"2025120618082163000_58.1.105.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91381-1"},{"key":"2025120618082163000_58.1.105.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80094-7"},{"key":"2025120618082163000_58.1.105.14","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(92)90001-P"},{"key":"2025120618082163000_58.1.105.15","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410130081008"},{"key":"2025120618082163000_58.1.105.16","doi-asserted-by":"publisher","DOI":"10.1086\/502059"},{"key":"2025120618082163000_58.1.105.17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1469"},{"key":"2025120618082163000_58.1.105.18","doi-asserted-by":"publisher","DOI":"10.1086\/497131"},{"key":"2025120618082163000_58.1.105.19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290311"},{"key":"2025120618082163000_58.1.105.20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/JCM.36.4.872-877.1998","article-title":"Different hepatitis C virus (HCV) RNA load profiles following seroconversion among injecting drug users without correlation with HCV genotype and serum alanine aminotransferase levels.","volume":"36","author":"Beld","year":"1998","journal-title":"J Clin Microbiol"},{"key":"2025120618082163000_58.1.105.21","doi-asserted-by":"crossref","unstructured":"Gold RG Siegel JE Russell LB Weinstein MC . Cost-effectiveness in health and medicine. New York: Oxford University Press, 1996.","DOI":"10.1093\/oso\/9780195108248.001.0001"},{"key":"2025120618082163000_58.1.105.22","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21197"},{"key":"2025120618082163000_58.1.105.23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01494.x"},{"key":"2025120618082163000_58.1.105.24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611213352115"},{"key":"2025120618082163000_58.1.105.25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342601"},{"key":"2025120618082163000_58.1.105.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200107053450107"},{"key":"2025120618082163000_58.1.105.27","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20742"},{"key":"2025120618082163000_58.1.105.28","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260701"},{"key":"2025120618082163000_58.1.105.29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107113250205"},{"key":"2025120618082163000_58.1.105.30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00280.x"},{"key":"2025120618082163000_58.1.105.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(99)00146-9"},{"key":"2025120618082163000_58.1.105.32","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1996)10:5<269::AID-JCLA7>3.0.CO;2-3"},{"key":"2025120618082163000_58.1.105.33","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.5.2027-2030.2004"},{"key":"2025120618082163000_58.1.105.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(01)00355-9"},{"key":"2025120618082163000_58.1.105.35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011232"},{"key":"2025120618082163000_58.1.105.36","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.01.034"},{"key":"2025120618082163000_58.1.105.37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300504"},{"key":"2025120618082163000_58.1.105.38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40976.x"},{"key":"2025120618082163000_58.1.105.39","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(95)71256-8"},{"key":"2025120618082163000_58.1.105.40","unstructured":"World Health Organization. Macroeconomics and health: investing in health for economic development. Report of the Commission on Macroeconomics and Health. Geneva: WHO, 2001."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2007.145516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:08:32Z","timestamp":1765073312000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2007.145516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,29]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,12,17]]},"published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1136\/gut.2007.145516"],"URL":"https:\/\/doi.org\/10.1136\/gut.2007.145516","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,29]]}}}