{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:42:51Z","timestamp":1790206971689,"version":"4.1.0"},"reference-count":45,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Barrett\u2019s oesophagus is associated with abdominal obesity. Adiponectin is a peptide that is secreted from adipocytes and circulates in three multimeric forms: low molecular weight (LMW), middle molecular weight (MMW), and high molecular weight (HMW). The anti-inflammatory effects of adiponectin are specific to individual multimers, with LMW being most anti-inflammatory. We postulated that circulating levels of adiponectin and its multimers would be associated with the risk of Barrett\u2019s oesophagus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Outpatient clinic in North Carolina, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Cases of Barrett\u2019s oesophagus and controls undergoing upper endoscopy for gastro-oesophageal reflux disease (GORD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures:<\/jats:title>\n                    <jats:p>Adjusted odds ratios of plasma adiponectin levels and its multimers for Barrett\u2019s oesophagus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 112 cases of Barrett\u2019s oesophagus and 199 GORD controls. Total adiponectin was not associated with Barrett\u2019s oesophagus (3\n                      <jats:sup>rd<\/jats:sup>\n                      tertile vs 1\n                      <jats:sup>st<\/jats:sup>\n                      tertile adjusted odds ratio (aOR) \u200a=\u200a0.88; 95% confidence interval (CI) \u200a=\u200a0.44 to 1.78). High levels of LMW adiponectin were associated with a decreased risk of Barrett\u2019s oesophagus (3\n                      <jats:sup>rd<\/jats:sup>\n                      tertile vs 1\n                      <jats:sup>st<\/jats:sup>\n                      tertile aOR\u200a=\u200a0.33; 95% CI, 0.16 to 0.69), and a high LMW\/total ratio appeared particularly inversely associated with Barrett\u2019s oesophagus (3\n                      <jats:sup>rd<\/jats:sup>\n                      tertile vs 1\n                      <jats:sup>st<\/jats:sup>\n                      tertile aOR\u200a=\u200a0.27; 95% CI, 0.13 to 0.58).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>High levels of LMW adiponectin are associated with a decreased risk of Barrett\u2019s oesophagus among patients with GORD. Further human studies are required to confirm these findings, and in vitro studies are needed to understand if there is a mechanism whereby adiponectin may affect Barrett\u2019s metaplasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2008.171553","type":"journal-article","created":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T20:19:08Z","timestamp":1246479548000},"page":"1583-1589","source":"Crossref","is-referenced-by-count":73,"title":["Association of adiponectin multimers with Barrett\u2019s oesophagus"],"prefix":"10.1136","volume":"58","author":[{"given":"J H","family":"Rubenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Y","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Madanick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Spacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J L","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S D","family":"Bright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N J","family":"Shaheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"2025121222011522000_58.12.1583.1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.046"},{"key":"2025121222011522000_58.12.1583.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.026"},{"key":"2025121222011522000_58.12.1583.3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-11-199906010-00003"},{"key":"2025121222011522000_58.12.1583.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"2025121222011522000_58.12.1583.5","first-page":"1293","article-title":"Risk factors for Barrett\u2019s esophagus in community-based practice. GORGE consortium. Gastroenterology Outcomes Research Group in Endoscopy.","volume":"92","author":"Lieberman","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121222011522000_58.12.1583.6","first-page":"27","article-title":"The relationship between gastroesophageal reflux disease and its complications with Barrett\u2019s esophagus.","volume":"92","author":"Eisen","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"2025121222011522000_58.12.1583.7","doi-asserted-by":"publisher","DOI":"10.1080\/00365520500535402"},{"key":"2025121222011522000_58.12.1583.8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.016"},{"key":"2025121222011522000_58.12.1583.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02727.x"},{"key":"2025121222011522000_58.12.1583.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"2025121222011522000_58.12.1583.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01116.x"},{"key":"2025121222011522000_58.12.1583.12","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.131243"},{"key":"2025121222011522000_58.12.1583.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01823.x"},{"key":"2025121222011522000_58.12.1583.14","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"2025121222011522000_58.12.1583.15","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1182\/blood.V96.5.1723","article-title":"Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.","volume":"96","author":"Yokota","year":"2000","journal-title":"Blood"},{"key":"2025121222011522000_58.12.1583.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.02.130"},{"key":"2025121222011522000_58.12.1583.17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603051"},{"key":"2025121222011522000_58.12.1583.18","doi-asserted-by":"crossref","first-page":"s858","DOI":"10.1093\/ajcn\/86.3.858S","article-title":"Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence.","volume":"86","author":"Barb","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"2025121222011522000_58.12.1583.19","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9922-1"},{"key":"2025121222011522000_58.12.1583.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2008.01.023"},{"key":"2025121222011522000_58.12.1583.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.01.046"},{"key":"2025121222011522000_58.12.1583.22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311113200"},{"key":"2025121222011522000_58.12.1583.23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300365200"},{"key":"2025121222011522000_58.12.1583.24","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000119921.86460.37"},{"key":"2025121222011522000_58.12.1583.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.07.106"},{"key":"2025121222011522000_58.12.1583.26","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hym158"},{"key":"2025121222011522000_58.12.1583.27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1858"},{"key":"2025121222011522000_58.12.1583.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.12.103"},{"key":"2025121222011522000_58.12.1583.29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030214"},{"key":"2025121222011522000_58.12.1583.30","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.","volume":"20","author":"Hotta","year":"2000","journal-title":"Arterioscl, Thromb Vascul Biol"},{"key":"2025121222011522000_58.12.1583.31","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1868"},{"key":"2025121222011522000_58.12.1583.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.09.014"},{"key":"2025121222011522000_58.12.1583.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.03.014"},{"key":"2025121222011522000_58.12.1583.34","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"2025121222011522000_58.12.1583.35","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501149200"},{"key":"2025121222011522000_58.12.1583.36","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1316"},{"key":"2025121222011522000_58.12.1583.37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209338"},{"key":"2025121222011522000_58.12.1583.38","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(03)00006-0"},{"key":"2025121222011522000_58.12.1583.39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03411-5"},{"key":"2025121222011522000_58.12.1583.40","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-0437-03"},{"key":"2025121222011522000_58.12.1583.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00090-1"},{"key":"2025121222011522000_58.12.1583.42","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031804"},{"key":"2025121222011522000_58.12.1583.43","first-page":"5699","article-title":"Association of serum adiponectin levels with breast cancer risk.","volume":"9","author":"Miyoshi","year":"2003","journal-title":"Clin Cancer Res"},{"key":"2025121222011522000_58.12.1583.44","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1975"},{"key":"2025121222011522000_58.12.1583.45","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.metabol.2008.01.027","article-title":"A dietary pattern characterized by high consumption of whole-grain cereals and low-fat dairy products and low consumption of refined cereals is positively associated with plasma adiponectin levels in healthy women.","volume":"57","author":"Yannakoulia","year":"2008","journal-title":"Metabol: Clin Exp"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.2008.171553","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:01:22Z","timestamp":1765605682000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.2008.171553"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,30]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,11,18]]},"published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1136\/gut.2008.171553"],"URL":"https:\/\/doi.org\/10.1136\/gut.2008.171553","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1168458.630643","asserted-by":"object"}]},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,30]]}}}