{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:31:12Z","timestamp":1790281872624,"version":"4.1.0"},"reference-count":28,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"accepted":{"date-parts":[[2010,9,14]]},"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The indications for intestinal transplantation (ITx) are still debated. Knowing survival rates and causes of death on home parenteral nutrition (HPN) will improve decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective 5-year study compared 389 non-candidates (no indication, no contraindication) and 156 candidates (indication, no contraindication) for ITx. Indications were: HPN failure (liver failure; multiple episodes of catheter-related venous thrombosis or sepsis; severe dehydration), high-risk underlying disease (intra-abdominal desmoids; congenital mucosal disorders; ultra-short bowel), high morbidity intestinal failure. Causes of death were defined as: HPN-related, underlying disease, or other cause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The survival rate was 87% in non-candidates, 73% in candidates with HPN failure, 84% in those with high-risk underlying disease, 100% in those with high morbidity intestinal failure and 54%, in ITx recipients (one non-candidate and 21 candidates) (p&lt;0.001). The primary cause of death on HPN was underlying disease-related in patients with HPN duration \u22642\u2005years, and HPN-related in those on HPN duration &gt;2\u2005years (p=0.006). In candidates, the death HRs were increased in those with desmoids (7.1; 95% CI 2.5 to 20.5; p=0.003) or liver failure (3.4; 95% CI 1.6 to 7.3; p=0.002) compared to non-candidates. In deceased candidates, the indications for ITx were the causes of death in 92% of those with desmoids or liver failure, and in 38% of those with other indications (p=0.041). In candidates with catheter-related complications or ultra-short bowel, the survival rate was 83% in those who remained on HPN and 78% after ITx (p=0.767).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HPN is confirmed as the primary treatment for intestinal failure. Desmoids and HPN-related liver failure constitute indications for life-saving ITx. Catheter-related complications and ultra-short bowel might be indications for pre-emptive\/rehabilitative ITx. In the early years after commencing HPN a life-saving ITx could be required for some patients at higher risk of death from their underlying disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/gut.2010.223255","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T21:09:57Z","timestamp":1289423397000},"page":"17-25","source":"Crossref","is-referenced-by-count":254,"title":["Long-term follow-up of patients on home parenteral nutrition in Europe: implications for intestinal transplantation"],"prefix":"10.1136","volume":"60","author":[{"given":"Loris","family":"Pironi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Colomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Lyszkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"H\u00e9buterne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Gambarara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gottrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cuerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Messing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Staun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Van Gossum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Home Artificial Nutrition & Chronic Intestinal Failure Working Group of the European Society for Clinical Nutrition and Metabolism (ESPEN)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,11,10]]},"reference":[{"key":"2025112111044338000_60.1.17.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.10.002"},{"key":"2025112111044338000_60.1.17.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00710.x"},{"key":"2025112111044338000_60.1.17.3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.043"},{"key":"2025112111044338000_60.1.17.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)70064-X"},{"key":"2025112111044338000_60.1.17.5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.005002080.x"},{"key":"2025112111044338000_60.1.17.6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.012"},{"key":"2025112111044338000_60.1.17.7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/SLA.0b013e3181b67725","article-title":"Five hundred intestinal and multivisceral transplantations at a single center: major advances with new challenges","volume":"250","author":"Abu-Elmagd","year":"2009","journal-title":"Ann Surg"},{"key":"2025112111044338000_60.1.17.8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.09.069"},{"key":"2025112111044338000_60.1.17.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804605"},{"key":"2025112111044338000_60.1.17.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0909351"},{"key":"2025112111044338000_60.1.17.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70388-4"},{"key":"2025112111044338000_60.1.17.12","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200105150-00001"},{"key":"2025112111044338000_60.1.17.13","unstructured":"2008 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 1998\u20132007. 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