{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:58:01Z","timestamp":1768622281596,"version":"3.49.0"},"reference-count":11,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1980,10]]},"abstract":"<jats:p>Cerebral oedema is the commonest immediate cause of death in fulminant hepatic failure and an investigation was carried out to determine the value of monitoring intracranial pressure (ICP) and to examine the effects of ICP of dexamethasone therapy and mannitol administration. ICP values in 10 patients at the time of insertion of a subdural pressure transducer (grade IV encephalopathy) averaged 15.5 +\/- SD 14.8 mmHg. Despite dexamethansone therapy, which had been started on admission, rises in ICP were subsequently observed in seven of the eight patients who died. In the two patients who survived, the highest reading were 47 and 35 mmHg. Mannitol consistently reversed or arrested ICP rises when pressure was &lt; 60 mmHg. ICP monitoring provides additional information in the managment of patients and is essential if mannitol therapy is to be used.<\/jats:p>","DOI":"10.1136\/gut.21.10.866","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"866-869","source":"Crossref","is-referenced-by-count":84,"title":["Clinical monitoring of intracranial pressure in fulminant hepatic failure."],"prefix":"10.1136","volume":"21","author":[{"given":"M A","family":"Hanid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Mellon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Silk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Strunin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"McCabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,10,1]]},"reference":[{"key":"ref_1","first-page":"615","article-title":"Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage","volume":"44","author":"Gazzard, B.G.; Portmann, B.; Murray-Lyon, I.M.; Williams, R.","year":"1975","unstructured":"Gazzard BG, Portmann B, Murray-Lyon IM, Williams R. Causes of death in fulminant hepatic failure and relationship to quantitative histological assessment of parenchymal damage. Q JMed 1975; 44: 615-26.","journal-title":"Q JMed"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0016-5085(19)33402-X","article-title":"Cerebral edema: a major complication of massive hepatic necrosis","volume":"61","author":"Ware, A.J.; D'Agostino, A.; Combes, B.","year":"1971","unstructured":"Ware AJ, D'Agostino A, Combes B. Cerebral edema: a major complication of massive hepatic necrosis. Gastroenterology 1971; 61: 877-84.","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"1","article-title":"Treatment of fulminant hepatic failure by polyacrylonitrile-membrane haemodialysis","volume":"2","author":"Silk, D.B.A.; Hanid, M.A.; Trewby, P.N.","year":"1977","unstructured":"Silk DBA, Hanid MA, Trewby PN et al. Treatment of fulminant hepatic failure by polyacrylonitrile-membrane haemodialysis. Lancet 1977; 2: 1-3.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0016-5085(79)80138-9","article-title":"Intracranial pressure in pigs with surgically induced acute liver failure","volume":"76","author":"Hanid, M.A.; Mackenzie, R.L.; Jenner, R.E.","year":"1979","unstructured":"Hanid MA, Mackenzie RL, Jenner RE et al. Intracranial pressure in pigs with surgically induced acute liver failure. Gastroenterology 1979; 76: 123-31.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/01.STR.7.4.410","article-title":"Mechanisms of postischemic brain edema: contribution of circulating factors","volume":"7","author":"Mchedlishvili, G.; Kapuscinski, A.; Nikolaishvili, L.","year":"1976","unstructured":"Mchedlishvili G, Kapuscinski A, Nikolaishvili L. Mechanisms of postischemic brain edema: contribution of circulating factors. 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JAMA 1975; 231: 822-5.","journal-title":"JAMA"},{"key":"ref_8","first-page":"595","article-title":"Prolonged continuous monitoring of intracranial pressure in severe Reye's syndrome","volume":"59","author":"Shaywitz, B.A.; Leventhal, J.M.; Kramer, M.S.; Venes, J.L.","year":"1977","unstructured":"Shaywitz BA, Leventhal JM, Kramer MS, Venes JL. Prolonged continuous monitoring of intracranial pressure in severe Reye's syndrome. Pediatrics 1977; 59: 595-605.","journal-title":"Pediatrics"},{"key":"ref_9","first-page":"606","article-title":"Intracranial pressure: monitoring and normalization therapy in children","volume":"59","author":"Mickell, J.J.; Reigel, D.H.; Cook, D.R.; Binda, R.E.; Safar, P.","year":"1977","unstructured":"Mickell JJ, Reigel DH, Cook DR, Binda RE, Safar P. Intracranial pressure: monitoring and normalization therapy in children. Pediatrics 1977; 59: 606-13.","journal-title":"Pediatrics"},{"issue":"149","key":"ref_10","article-title":"Continuous recording and control of ventricular fluid pressure in neurosurgical practice","volume":"1960","author":"Lundberg, N.","unstructured":"Lundberg N. Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psychiatr Neurologica Scand 1960, suppl 149.","journal-title":"Acta Psychiatr Neurologica Scand"},{"key":"ref_11","first-page":"697","article-title":"Changes in the blood-brain barrier in hepatic coma after hepatectomy","volume-title":"the rat. Gastroenterology","volume":"73","author":"Livingstone, A.S.; Potvin, M.; Goresky, C.A.; Finlayson, M.H.; Hinchey, E.J.","year":"1977","unstructured":"Livingstone AS, Potvin M, Goresky CA, Finlayson MH, Hinchey EJ. Changes in the blood-brain barrier in hepatic coma after hepatectomy in the rat. Gastroenterology 1977; 73: 697-704."}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.21.10.866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T19:32:02Z","timestamp":1757273522000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.21.10.866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1980,10,1]]},"published-print":{"date-parts":[[1980,10]]}},"alternative-id":["10.1136\/gut.21.10.866"],"URL":"https:\/\/doi.org\/10.1136\/gut.21.10.866","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,10]]}}}