{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:55:30Z","timestamp":1779933330000,"version":"3.53.1"},"reference-count":36,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1980,2]]},"abstract":"<jats:p>Intraluminal manometric studies were performed in 14 chagasic patients with megaoesophagus, 10 chagasic patients with megacolon, and 15 control subjects. Basal lower oesophageal sphincter pressure was 20.27+\/-1.16 mmHg (mean+\/-SEM) in controls as compared wtih 15.16+\/-1.53 mmHg in chagasics with megaoesophagus and 14.38+\/-1.50 mmHg in chagasics with megacolon. Dose-response studies to intravenous pentagastrin showed that the chagasic patients exhibited a lower sensitivity to the stimulant than did the controls, as demonstrated by shifting of the dose-response curve to the right and higher individual values of the dose for half maximal contraction (D50). No difference was noted between the calculated maximal contraction (Vmax) of oesophageal sphincter of controls and chagasics. These data are compatible with the hypothesis of an interaction between pentagastrin and cholinergic nervous excitation on oesophageal sphincteric smooth muscle.<\/jats:p>","DOI":"10.1136\/gut.21.2.85","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"85-90","source":"Crossref","is-referenced-by-count":19,"title":["Lower oesophageal sphincter response to pentagastrin in chagasic patients with megaoesophagus and megacolon."],"prefix":"10.1136","volume":"21","author":[{"given":"W","family":"Padovan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R O","family":"Dantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U G","family":"Meneghelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R B","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L E","family":"Troncon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,2,1]]},"reference":[{"key":"ref_1","first-page":"834","article-title":"Studies on sphincter competence (Abstract)","volume":"66","author":"Behar, J.; Kastendieck, J.","year":"1974","unstructured":"Behar, J., and Kastendieck, J. (1974). Studies on sphincter competence (Abstract). Gastroenterology, 66, 834.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/208170a0","article-title":"Effect of gastrin on isolated smooth muscle preparations","volume":"208","author":"Bennett, A.","year":"1965","unstructured":"Bennett, A. (1965). Effect of gastrin on isolated smooth muscle preparations. Nature (London), 208, 170-173.","journal-title":"Nature (London)"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1001\/archsurg.1971.01350010008002","article-title":"Transabdominal vagectomy and lower esophageal function","volume":"102","author":"Blackman, A.H.; Rakatansky, H.; Nasrullah, M.; Thayer, Jr, W.R.","year":"1971","unstructured":"Blackman, A. H., Rakatansky, H., Nasrullah, M., and Thayer, W. R., Jr. (1971). Transabdominal vagectomy and lower esophageal function. Archives of Surgery, 102, 6-8.","journal-title":"Archives of Surgery"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/00000441-193912000-00001","article-title":"A law of devervation","volume":"198","author":"Cannon, W.B.","year":"1939","unstructured":"Cannon, W. B. (1939). A law of devervation. American Journal of Medical Sciences, 198, 737-750.","journal-title":"American Journal of Medical Sciences"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/00000658-196409000-00010","article-title":"Achalasia of the esophagus: pathologic and etiologic considerations","volume":"160","year":"1964","unstructured":"Cassella, R. R., Brown, A. L. Jr, Sayre, G. P., and Ellis, F. H. Jr. (1964). Achalasia of the esophagus: pathologic and etiologic considerations. Annals of Surgery, 160, 474-487..","journal-title":"Annals of Surgery"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.7326\/0003-4819-83-3-390","article-title":"The lower esophageal sphincter. Physiologic and clinical aspects","volume":"83","author":"Castell, D. 0","year":"1975","unstructured":"Castell, D. 0. (1975). The lower esophageal sphincter. Physiologic and clinical aspects. Annals of Internal Medicine, 83, 390-401.","journal-title":"Annals of Internal Medicine"},{"key":"ref_7","first-page":"864","article-title":"'Cardiospasm' in achalasia: demonstration of an abnormally elevated esophagogastric sphincter pressure with partial relaxation on swallowing (Abstract)","volume":"48","author":"Cohen, B.R.","year":"1965","unstructured":"Cohen, B. R. (1965). 'Cardiospasm' in achalasia: demonstration of an abnormally elevated esophagogastric sphincter pressure with partial relaxation on swallowing (Abstract). Gastroenterology, 48, 864.","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0016-5085(19)33182-8","article-title":"The lower esophageal sphincter","volume":"63","author":"Cohen, S.; Harris, L.D.","year":"1972","unstructured":"Cohen, S., and Harris, L. D. (1972). The lower esophageal sphincter. Gastroenterology, 63, 1066-1073.","journal-title":"Gastroenterology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0016-5085(19)33392-X","article-title":"Lower esophageal sphincter dysfunction in achalasia","volume":"61","author":"Cohen, S.; Lipshutz, W.","year":"1971","unstructured":"Cohen, S., and Lipshutz, W. (1971). Lower esophageal sphincter dysfunction in achalasia. Gastroenterology, 61, 814-820.","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1172\/JCI106601","article-title":"Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasia","volume":"50","author":"Cohen, S.; Lipshutz, W.; Hughes, W.","year":"1971","unstructured":"Cohen, S., Lipshutz, W., and Hughes, W. (1971). Role of gastrin supersensitivity in the pathogenesis of lower esophageal sphincter hypertension in achalasia. Journal of Clinical Investigation, 50, 1241-1247.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_11","first-page":"299","article-title":"Manometric study of the effect of vagotomy on the gastroesophageal sphincter","volume":"10","author":"Crispin, J.S.; McIver, D.K.; Lind, J.F.","year":"1967","unstructured":"Crispin, J. S., McIver, D. K., and Lind, J. F. (1967). Manometric study of the effect of vagotomy on the gastroesophageal sphincter. Canadian Jouirnal of Surgery, 10, 299-303.","journal-title":"Canadian Jouirnal of Surgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0016-5085(19)32858-6","article-title":"The nature of gastrin's action on the lower esophageal sphincter (letter)","volume":"67","author":"Davison, J.S.","year":"1974","unstructured":"Davison, J. S. (1974). The nature of gastrin's action on the lower esophageal sphincter (letter). Gastroenterology, 67, 558-559.","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1001\/archinte.1976.03630050009004","article-title":"Instrumentation and methods for intraluminal esophageal manometry","volume":"136","author":"Dodds, W.J.","year":"1976","unstructured":"Dodds, W. J. (1976). Instrumentation and methods for intraluminal esophageal manometry. Archives of Internal Medicine, 136, 515-523.","journal-title":"Archives of Internal Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF01237786","article-title":"Effect of increased intra-abdominal pressure on lower esophageal sphincter pressure","volume":"20","author":"Dodds, W.J.; Hogan, W.J.; Miller, W.N.; Stef, J.J.; Arndorfer, R.C.; Lydon, S.B.","year":"1975","unstructured":"Dodds, W. J., Hogan, W. J., Miller, W. N., Stef, J. J., Arndorfer, R. C., and Lydon, S. B. (1975). Effect of increased intra-abdominal pressure on lower esophageal sphincter pressure. American Journal of Digestive Diseases, 20, 298-308.","journal-title":"American Journal of Digestive Diseases"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0021-9258(17)45254-9","article-title":"A comparison of estimates of Michaelis-Menten kinetic constants from various linear transformations","volume":"240","author":"Dowd, J.E.; Riggs, D.S.","year":"1965","unstructured":"Dowd, J. E., and Riggs, D. S. (1965). A comparison of estimates of Michaelis-Menten kinetic constants from various linear transformations. Journal of Biological Chemistry, 240, 863-869.","journal-title":"Journal of Biological Chemistry"},{"key":"ref_16","article-title":"Measurements and comparisons of lower esophageal sphincter pressures and serum gastrin levels in patients with gastroesophageal reflux","author":"Farrell, R.L.; Castell, D.O.; McGuigan, J.E.","year":"1974","unstructured":"Farrell, R. L., Castell, D. O., and McGuigan, J. E. (1974). Measurements and comparisons of lower esophageal sphincter pressures and serum gastrin levels in patients with gastroesophageal reflux."},{"key":"ref_17","article-title":"Lower esophageal sphincter (LES) and gastric acid (GA) responses to intravenous infusions of synthetic human gastrin heptadecapeptide","author":"Freeland, G.R.; Higgs, R.H.; Castell, D.O.; McGuigan, J.E.","year":"1975","unstructured":"Freeland, G. R., Higgs, R. H., and Castell, D. O., and McGuigan, J. E. (1975). Lower esophageal sphincter (LES) and gastric acid (GA) responses to intravenous infusions of synthetic human gastrin heptadecapeptide"},{"key":"ref_18","first-page":"257","article-title":"ReacJo de fixagdo do complemento para diagn6stico da molestia de Chagas pela tecnica quantitativa: vantagens do metodo e sua aplicacao em Saude Publica","volume":"41","author":"de Freitas, J.L.P.","year":"1952","unstructured":"de Freitas, J. L. P. (1952). ReacJo de fixagdo do complemento para diagn6stico da molestia de Chagas pela tecnica quantitativa: vantagens do metodo e sua aplicacao em Saude Publica. Hospital (Rio), 41, 257-267.","journal-title":"Hospital (Rio)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1056\/NEJM197410172911616","article-title":"Does gastrin act via cholinergic neurons to maintain basal lower-esophageal sphincter pressure? (Letter)","volume":"291","author":"Goyal, R.K.","year":"1974","unstructured":"Goyal, R. K. (1974). Does gastrin act via cholinergic neurons to maintain basal lower-esophageal sphincter pressure? (Letter). New England Journal of Medicine, 291, 849-850.","journal-title":"New England Journal of Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM197311012891820","article-title":"Lower-esophageal sphincter response to pentagastrin (letter)","volume":"289","author":"Grossman, M.I.","year":"1973","unstructured":"Grossman, M. I. (1973). Lower-esophageal sphincter response to pentagastrin (letter). New England Journal of Medicine, 289, 981.","journal-title":"New England Journal of Medicine"},{"key":"ref_21","first-page":"10","article-title":"Increased response of the lower esophageal sphincter after truncal vagotomy (Abstract)","volume":"23","author":"Higgs, R. H.; Castell, D. 0","year":"1975","unstructured":"Higgs, R. H., and Castell, D. 0. (1975). Increased response of the lower esophageal sphincter after truncal vagotomy (Abstract). Clinical Research, 23, 16A. Koeberle, F. (1956). Patogenese dos megas. Revista Goiana de Medicina, 2, 101-1 10.","journal-title":"Clinical Research; Patogenese dos megas"},{"key":"ref_22","article-title":"Patogenia da molestia de Chagas","author":"Koeberle, F.","year":"1957","unstructured":"Koeberle, F. (1957). Patogenia da molestia de Chagas."},{"key":"ref_23","article-title":"Patogenia do Megaesofago Brasileiro e Europeu. Thesis. Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo","author":"Koberle, F.","year":"1962","unstructured":"Koberle, F. (1962). Patogenia do Megaesofago Brasileiro e Europeu. Thesis. Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1139\/y68-039","article-title":"The effect of atropine on the gastroesophageal sphincter","volume":"46","author":"Lind, J.F.; Crispin, J.S.; McIver, D.K.","year":"1968","unstructured":"Lind, J. F., Crispin, J. S., and McIver, D. K. (1968). The effect of atropine on the gastroesophageal sphincter. Canadian Journal ofPhysiology and Pharmacology, 46, 233-238.","journal-title":"Canadian Journal ofPhysiology and Pharmacology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0016-5085(19)33495-X","article-title":"A comparison of the site of action of gastrin I on lower esophageal sphincter and antral circular smooth muscle","volume":"61","author":"Lipshutz, W.; Tuch, A.F.; Cohen, S.","year":"1971","unstructured":"Lipshutz, W., Tuch, A. F., and Cohen, S. (1971). A comparison of the site of action of gastrin I on lower esophageal sphincter and antral circular smooth muscle. Gastroenterology, 61, 454-460.","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/gut.9.6.688","article-title":"The effect of vagotomy on the human gastroesophageal sphincter","volume":"9","author":"Mann, C.V.; Hardcastle, J.D.","year":"1968","unstructured":"Mann, C. V., and Hardcastle, J. D. (1968). The effect of vagotomy on the human gastroesophageal sphincter. Gut, 9, 688-695.","journal-title":"Gut"},{"key":"ref_27","first-page":"818","article-title":"Effect of transabdominal vagotomy on the human gastroesophageal high-pressure zone","volume":"73","author":"Mazur, J.M.; Skinner, D.B.; Jones, E.L.; Zuidema, G.D.","year":"1973","unstructured":"Mazur, J. M., Skinner, D. B., Jones, E. L., and Zuidema, G. D. (1973). Effect of transabdominal vagotomy on the human gastroesophageal high-pressure zone. SurgerY, 73, 818-822.","journal-title":"SurgerY"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0016-5085(19)33219-6","article-title":"Lower esophageal sphincter pressure changes after food ingestion","volume":"63","author":"Nebel, 0. T.; Castell, D. 0","year":"1972","unstructured":"Nebel, 0. T., and Castell, D. 0. (1972). Lower esophageal sphincter pressure changes after food ingestion. Gastroenterology, 63, 778-783.","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/gut.14.4.270","article-title":"Inhibition of the lower oesophageal sphincter by fat. A mechanism for fatty food intolerance","volume":"14","author":"Nebel, 0. T.; Castell, D. 0","year":"1973","unstructured":"Nebel, 0. T., and Castell, D. 0. (1973). Inhibition of the lower oesophageal sphincter by fat. A mechanism for fatty food intolerance. Gut, 14, 270-274.","journal-title":"Gut"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/BF01073080","article-title":"Gastric secretory and motility studies in chronic chagasic patients","volume":"22","author":"Padovan, W.V.; Meneghelli, U.G.; Alves de Godoy, R.","year":"1977","unstructured":"Padovan, WV., Meneghelli, U. G., and Alves de Godoy, R. (1977). Gastric secretory and motility studies in chronic chagasic patients. American Journal ofDigestive Diseases, 22, 618-622.","journal-title":"American Journal ofDigestive Diseases"},{"key":"ref_31","article-title":"Acid and pepsin secretion in chronic chagasic patients in response to graded doses of pentagastrin and pentagastrin plus urecholine. In preparation","year":"1979","unstructured":"Padovan, W., Alves de Godoy, R., Meneghelli, U. G., Oliveira, R. B., and Dantas, R. 0. (1979). Acid and pepsin secretion in chronic chagasic patients in response to graded doses of pentagastrin and pentagastrin plus urecholine. In preparation."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1172\/JCI107829","article-title":"Neural control of lower esophageal sphincter","volume":"54","author":"Rattan, S.; Goyal, R.K.","year":"1974","unstructured":"Rattan, S., and Goyal, R. K. (1974). Neural control of lower esophageal sphincter. Journal of Clinical Investigation, 54, 899-906.","journal-title":"Journal of Clinical Investigation"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1152\/ajplegacy.1972.222.4.967","article-title":"Cholinergic response of the lower esophageal sphincter","volume":"222","year":"1972","unstructured":"Roling, G. T., Farrell, R. L., and Castell, D. 0. (1972). Cholinergic response of the lower esophageal sphincter. American Journal ofPhysiology, 222, 967-972.","journal-title":"American Journal ofPhysiology"},{"key":"ref_34","first-page":"433","article-title":"Studies in achalasia of the cardia","volume":"26","author":"Trounce, J.R.; Deuchar, D.C.; Kauntze, R.; Thomas, G.A.","year":"1957","unstructured":"Trounce, J. R., Deuchar, D. C., Kauntze, R., and Thomas, G. A. (1957). Studies in achalasia of the cardia. Quarterly Journal of Medicine, 26, 433-443.","journal-title":"Quarterly Journal of Medicine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0016-5085(73)80038-1","article-title":"Evidence that acetylcholine released by gastrin and related polypeptides contribute to their effect on gastrointestinal motility","volume":"64","author":"Vizi, S.E.; Bertaccini, G.; Impicciatori, M.; Knoll, J.","year":"1973","unstructured":"Vizi, S. E., Bertaccini, G., Impicciatori, M., and Knoll, J. (1973). Evidence that acetylcholine released by gastrin and related polypeptides contribute to their effect on gastrointestinal motility. Gastroenterology, 64, 268-277.","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1172\/JCI108435","article-title":"Mechanism of action of pentagastrin on the lower esophageal sphincter","volume":"57","author":"Zwick, R.; Bowes, K.L.; Daniel, E.E.; Sarna, S.K.","year":"1976","unstructured":"Zwick, R., Bowes, K. L., Daniel, E. E., and Sarna, S. K. (1976). Mechanism of action of pentagastrin on the lower esophageal sphincter. Journal of Clinical Investigation, 57, 1644-1651.","journal-title":"Journal of Clinical Investigation"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.21.2.85","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:38:45Z","timestamp":1764988725000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.21.2.85"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1980,2,1]]},"published-print":{"date-parts":[[1980,2]]}},"alternative-id":["10.1136\/gut.21.2.85"],"URL":"https:\/\/doi.org\/10.1136\/gut.21.2.85","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,2]]}}}