{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:25:42Z","timestamp":1780593942257,"version":"3.54.1"},"reference-count":17,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1980,3]]},"abstract":"<jats:p>Fifty patients presenting sequentially with a history of recurrent aphthae were investigated for evidence of nutritional deficiencies and coeliac disease. In the group, two patients were found to have coeliac disease and their recurrent aphthae cleared soon after starting a gluten free diet. This study confirms the presence of an increased prevalence of nutritional deficiency and of coeliac disease in aphthous patients. However, it is recommended that jejunal biopsy be carried out in these cases only where there is evidence of malabsorption.<\/jats:p>","DOI":"10.1136\/gut.21.3.223","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"223-226","source":"Crossref","is-referenced-by-count":87,"title":["Coeliac disease associated with recurrent aphthae."],"prefix":"10.1136","volume":"21","author":[{"given":"M M","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Carmichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R I","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F D","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/bmj.2.5969.490","article-title":"Recurrent aphthae: treatment with vilamin Bl 2, folic acid, and iron","volume":"2","author":"Wray, D.; Ferguson, M.M.; Mason, D.K.; Hutcheon, A.W.; Dagg, J.H.","year":"1975","unstructured":"Wray D, Ferguson MM, Mason DK, Hutcheon, AW, Dagg JH. Recurrent aphthae: treatment with vilamin Bl 2, folic acid, and iron. Br MedJ 1975; 2: 490-3.","journal-title":"Br MedJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/bmj.1.6000.11","article-title":"Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration","volume":"1","author":"Ferguson, R.; Basu, M.K.; Asquith, P.; Cooke, W.T.","year":"1976","unstructured":"Ferguson R, Basu MK, Asquith P, Cooke WT. Jejunal mucosal abnormalities in patients with recurrent aphthous ulceration. Br MedJ 1976; 1: 11-3.","journal-title":"Br MedJ"},{"issue":"2","key":"ref_3","first-page":"1727","article-title":"An immunological study of coeliac disease and idiopathic steatorrhoea","volume":"1961","author":"Taylor, K.B.; Thomson, D.L.; Truelove, S.C.; Wright, R.","unstructured":"Taylor KB, Thomson DL, Truelove SC, Wright R. An immunological study of coeliac disease and idiopathic steatorrhoea. Br MedJ 1961; 2: 1727-31.","journal-title":"Br MedJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0016-5085(64)80046-9","article-title":"Serologic reactions to gluten and cow's milk proteins in gastrointestinal disease","volume":"46","author":"Taylor, K.B.; Truleove, S.C.; Wright, R.","year":"1964","unstructured":"Taylor KB, Truleove SC, Wright R. Serologic reactions to gluten and cow's milk proteins in gastrointestinal disease. Gastroenterology 1964; 46: 99-108.","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jcp.26.5.371","article-title":"Food antibodies in oral disease: a study of serum antibodies to food proteins in aphthous ulceration and other oral diseases","volume":"26","author":"Thomas, H.C.; Ferguson, A.; McLennan, J.G.; Mason, D.K.","year":"1973","unstructured":"Thomas HC, Ferguson A, McLennan JG, Mason DK. Food antibodies in oral disease: a study of serum antibodies to food proteins in aphthous ulceration and other oral diseases. J Clin Pathol 1973; 26: 371-4.","journal-title":"J Clin Pathol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1136\/jcp.29.6.484","article-title":"Anticonnective tissue and other antitissue 'antibodies' in the sera of patients with coeliac disease compared with the findings in a mixed hospital population","volume":"29","author":"Williamson, N.; Asquith, P.; Stokes, P.L.; Jowett, A.W.; Cooke, W.T.","year":"1976","unstructured":"Williamson N, Asquith P, Stokes PL, Jowett AW, Cooke WT. Anticonnective tissue and other antitissue 'antibodies' in the sera of patients with coeliac disease compared with the findings in a mixed hospital population. J Clin Pathol 1976; 29: 484-94.","journal-title":"J Clin Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0022-3476(62)80192-9","article-title":"Precipitins to antigens of wheat and cow's milk in celiac disease","volume":"61","author":"Heiner, D.C.; Lahey, M.E.; Wilson, J.F.; Gerrard, J.W.; Shwachman, H.; Khaw, K.T.","year":"1962","unstructured":"Heiner DC, Lahey ME, Wilson JF, Gerrard JW, Shwachman H, Khaw KT. Precipitins to antigens of wheat and cow's milk in celiac disease. J Pediatr 1962; 61: 813-30.","journal-title":"J Pediatr"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0003-9861(66)90408-5","article-title":"An immunological study of wheat gluten proteins and derivatives","volume":"177","author":"Beckwith, A.C.; Heiner, D.C.","year":"1966","unstructured":"Beckwith AC, Heiner DC. An immunological study of wheat gluten proteins and derivatives. Arch Biochem 1966; 177:239-247.","journal-title":"Arch Biochem"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/BF02231100","article-title":"Intraluminal biopsy of the small intestine","volume":"2","author":"Crosby, W.H.; Kugler, H.W.","year":"1957","unstructured":"Crosby WH, Kugler HW. Intraluminal biopsy of the small intestine. Am J Dig Dis 1957; 2: 236-41.","journal-title":"Am J Dig Dis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/0003-2697(64)90115-0","article-title":"Method for assay of intestinal disaccharidases","volume":"7","author":"Dahlquist, A.","year":"1964","unstructured":"Dahlquist A. Method for assay of intestinal disaccharidases. Ann Biochem 1964; 7: 18-25.","journal-title":"Ann Biochem"},{"key":"ref_11","article-title":"The intestinal mucosa in health and disease","author":"Lee, F.D.","year":"1970","unstructured":"Lee FD. The intestinal mucosa in health and disease. University of Dundee: MD Thesis, 1970."},{"key":"ref_12","first-page":"485","article-title":"Presence of circulating antibodies to gluten and milk fractions in patients with nontropical sprue","volume":"36","author":"Alarcon-Segovia, D.; Herskovic, T.; Wakim, K.G.; Green, P.A.; Scudamore, H.H.","year":"1964","unstructured":"Alarcon-Segovia D, Herskovic T, Wakim KG, Green PA, Scudamore HH. Presence of circulating antibodies to gluten and milk fractions in patients with nontropical sprue. Am JMed 1964; 36: 485-99.","journal-title":"Am JMed"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(70)90624-0","article-title":"Precipitins to aqueous extract of flour in coeliac disease (Letter)","volume":"1","author":"Rossipal, E.","year":"1970","unstructured":"Rossipal, E. Precipitins to aqueous extract of flour in coeliac disease (Letter). Lancet 1970; 1: 251-2.","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/bmj.1.5792.75","article-title":"Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children","volume":"1","author":"Ferguson, A.; Carswell, F.","year":"1972","unstructured":"Ferguson A, Carswell F. Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children. Br MedJ 1972; 1: 75-7.","journal-title":"Br MedJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/bmj.3.5725.725","article-title":"Enterocyte in coeliac disease-1","volume":"3","author":"Booth, C.C.","year":"1970","unstructured":"Booth CC. Enterocyte in coeliac disease-1. Br Med J 1970; 3: 725-31.","journal-title":"Br Med J"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/gut.11.8.635","article-title":"Immunoglobulins and dietary protein antibodies in childhood coeliac disease","volume":"11","author":"Kenrick, K.G.; Walker-Smith, J.A.","year":"1970","unstructured":"Kenrick KG, Walker-Smith JA. Immunoglobulins and dietary protein antibodies in childhood coeliac disease. Gut 1970; 11: 635-40.","journal-title":"Gut"},{"key":"ref_17","first-page":"418","article-title":"Nutritional deficiencies in recurrent aphthae","volume":"7","author":"Wray, D.; Ferguson, M.M.; Hutcheon, W.A.; Dagg, J.H.","year":"1979","unstructured":"Wray D, Ferguson MM, Hutcheon WA, Dagg JH. Nutritional deficiencies in recurrent aphthae. J Oral Pathol 1979; 7: 418-23.","journal-title":"J Oral Pathol"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.21.3.223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T18:50:27Z","timestamp":1757271027000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.21.3.223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1980,3,1]]},"published-print":{"date-parts":[[1980,3]]}},"alternative-id":["10.1136\/gut.21.3.223"],"URL":"https:\/\/doi.org\/10.1136\/gut.21.3.223","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3]]}}}