{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:15:17Z","timestamp":1765649717288,"version":"3.48.0"},"reference-count":27,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1980,4]]},"abstract":"<jats:p>The effects of four different doses of ursodeoxycholic acid (250, 500, 750, and 1000 mg daily) on biliary lipids were studied in 24 patients with radiolucent gallbladder stones. There was a significant increase in the proportion of ursodeoxycholic acid in bile after all doses, being greatest with 750 and 1000 mg daily. Unsulphated lithocholic acid was also increased in the bile after therapy, while the other major bile acids were reduced. The cholesterol content of bile was reduced by all doses, and this change was most marked after 1000 mg (from 10.9 +\/- 1.4 to 5.6 +\/- 0.5 mol%, P &lt; 0.01). Biliary cholesterol saturation improved significantly only after 750 and 1000 mg daily.<\/jats:p>","DOI":"10.1136\/gut.21.4.305","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"305-310","source":"Crossref","is-referenced-by-count":18,"title":["Ursodeoxycholic acid therapy and biliary lipids--a dose-response study."],"prefix":"10.1136","volume":"21","author":[{"given":"M C","family":"Bateson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P E","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Murison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Bouchier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,4,1]]},"reference":[{"key":"ref_1","first-page":"168","article-title":"Chenodeoxycholic acid efficacy in gallstone disease-a controlled study (Abstract)","volume":"13","author":"Gerolami, A.; Sarles, H.; Brette, R.","year":"1975","unstructured":"Gerolami A, Sarles H, Brette R, et al. Chenodeoxycholic acid efficacy in gallstone disease-a controlled study (Abstract). Digestion 1975; 13: 168-9.","journal-title":"Digestion"},{"key":"ref_2","first-page":"1232","article-title":"Chenodeoxycholic acid therapy for the dissolution of gallstones. Its efficacy and safety","volume":"73","author":"Ono, T.; Ohto, M.; Kawamura, K.","year":"1976","unstructured":"Ono T, Ohto M, Kawamura K, et al. Chenodeoxycholic acid therapy for the dissolution of gallstones. Its efficacy and safety. Jap J Gastroenterol 1976; 73: 1232-46.","journal-title":"Jap J Gastroenterol"},{"key":"ref_3","first-page":"3355","article-title":"II trattamento medico della calcolosi biliare colesterolica nell'uomo con acido chenodesossicolico","volume":"69","author":"Barbara, L.; Roda, E.; Roda, A.","year":"1977","unstructured":"Barbara L, Roda E, Roda A, et al. II trattamento medico della calcolosi biliare colesterolica nell'uomo con acido chenodesossicolico. 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Metabolism of ursodeoxycholic acid in Gut; Mosbach acid on bile in patients with and without gallstones","volume":"18","author":"with chenodeoxycholic 30Fedorowski; T, Salen G.; A, Colallilo; GS, Tint","year":"1977","unstructured":"Bateson MC, Ross PE, Murison J, Bouchier IAD. man. Gastroenterology 1977; 72: 1036. (Abstract.)"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0016-5085(19)31871-2","volume":"73","author":"man","year":"1977","unstructured":"Effect of prolonged feeding with chenodeoxycholic 30Fedorowski T, Salen G, Colallilo A, Tint GS, Mosbach acid on bile in patients with and without gallstones. EH, Hall JC. Metabolism of ursodeoxycholic acid in Gut 1977; 18: 599-605.","journal-title":"Gastroenterology"},{"key":"ref_19","article-title":"cholic acid treatment of gallstones. Dose-response Faecal bile acid (BA) excretion in patients with cholestudy and possible mechanism of action","author":"CDCA","year":"1977","unstructured":"man. 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Gastroenterology 1978; 75: 1016-20.","journal-title":"Br Med J"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.21.4.305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T18:12:01Z","timestamp":1765649521000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.21.4.305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1980,4,1]]},"published-print":{"date-parts":[[1980,4]]}},"alternative-id":["10.1136\/gut.21.4.305"],"URL":"https:\/\/doi.org\/10.1136\/gut.21.4.305","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1980,4]]}}}