{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:01:45Z","timestamp":1793156505984,"version":"4.5.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1980,6]]},"abstract":"<jats:p>During the period 1955 to 1974 inclusive, 826 patients developed Crohn's disease and were registered citizens of Stockholm County at the time of definite diagnosis. These patients were followed up and investigated with reference to the occurrence of and outcome after treatment for anal fistulae. These fistulae were recorded in 184 patients (23%). The incidence of anal fistulae increased the further distally the intestinal lesion was located. Healing followed local operation for anal fistula before curative intestinal resection in approximately 60% of the patients with small intestinal and combined ileocolic disease. However, patients with colonic Crohn's disease did not heal after such treatment. When curative intestinal resection was the primary procedure, 47% of the patients healed spontaneously. Small intestinal and combined ileocolic disease was associated with a good prognosis--90% were healed at follow-up, while patients with colonic disease had a poor prognosis. The combination of rectal Crohn's disease and anal fistula invariably led to proctocolectomy.<\/jats:p>","DOI":"10.1136\/gut.21.6.525","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"525-527","source":"Crossref","is-referenced-by-count":409,"title":["Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease."],"prefix":"10.1136","volume":"21","author":[{"given":"G","family":"Hellers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Bergstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ewerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/gut.5.6.493","article-title":"Crohn's disease of the large intestine","volume":"5","author":"Lockhart-Mummery, H.E.; Morson, B.C.","year":"1964","unstructured":"Lockhart-Mummery HE, Morson BC. Crohn's disease of the large intestine. Gut 1964; 5: 493-509.","journal-title":"Gut"},{"key":"ref_2","first-page":"115","article-title":"Crohn's disease","volume":"9","author":"Edwards, H.","year":"1964","unstructured":"Edwards H. Crohn's disease. J Roy Coll Surg Edinb 1964; 9: 115-27.","journal-title":"J Roy Coll Surg Edinb"},{"issue":"44","key":"ref_3","first-page":"121","article-title":"Crohn's disease: an inquiry into its nature and consequences","volume":"1969","author":"Edwards, H.","unstructured":"Edwards H. Crohn's disease: an inquiry into its nature and consequences. Ann Roy Coll Surg Engl 1969; 44: 121-39.","journal-title":"Ann Roy Coll Surg Engl"},{"key":"ref_4","first-page":"258","article-title":"The natural history and treatment of Crohn's disease","volume":"36","author":"Schofield, P.F.","year":"1965","unstructured":"Schofield PF. The natural history and treatment of Crohn's disease. Ann Roy Coll Surg Engl 1965; 36: 258-79.","journal-title":"Ann Roy Coll Surg Engl"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/gut.12.9.739","article-title":"The place of surgery in Crohn's disease","volume":"12","author":"Alexander-Williams, J.","year":"1971","unstructured":"Alexander-Williams J. The place of surgery in Crohn's disease. Gut 1971; 12: 739-49.","journal-title":"Gut"},{"key":"ref_6","first-page":"469","article-title":"Surgery and the management of Crohn's disease","volume":"1","author":"Alexander-Williams, J.","year":"1972","unstructured":"Alexander-Williams J. Surgery and the management of Crohn's disease. Clin Gastroenterol 1972; 1: 469-91.","journal-title":"Clin Gastroenterol"},{"key":"ref_7","first-page":"32","article-title":"Perianal lesions in Crohn's disease","volume":"17","author":"Fielding, J.F.","year":"1972","unstructured":"Fielding JF. Perianal lesions in Crohn's disease. J Roy Coll Surg Edinb 1972; 17: 32-7.","journal-title":"J Roy Coll Surg Edinb"},{"key":"ref_8","article-title":"Regional ileitis","author":"Crohn, B.B.; Yarnis, H.","year":"1958","unstructured":"Crohn BB, Yarnis H. Regional ileitis, 2nd ed. New York: Grune and Stratton, 1958.","edition":"2nd ed"},{"key":"ref_9","first-page":"377","article-title":"Anal lesions in Crohn's disease","volume":"1","author":"Lockhart-Mummery, H.E.","year":"1972","unstructured":"Lockhart-Mummery HE. Anal lesions in Crohn's disease. Clin Gastroenterol 1972; 1: 377-82.","journal-title":"Clin Gastroenterol"},{"key":"ref_10","first-page":"1013","article-title":"Crohn's disease. In: Surgery of the anus, colon and rectum","author":"Goligher, J.C.","year":"1975","unstructured":"Goligher JC. Crohn's disease. In: Surgery of the anus, colon and rectum, 3rd ed. London: Bailliere 1975: 1013-44.","edition":"3rd ed"},{"key":"ref_11","article-title":"Course and long-term prognosis of Crohn's disease","author":"Weterman, I.T.","year":"1976","unstructured":"Weterman IT. Course and long-term prognosis of Crohn's disease. Leyden: Thesis, 1976."},{"key":"ref_12","first-page":"105","article-title":"Definition and diagnosis of Crohn's disease","volume-title":"enteritis (Crohn's disease) (Skandia International Symposia 5","author":"Lennard-Jones, J.E.","year":"1971","unstructured":"Lennard-Jones JE. Definition and diagnosis of Crohn's disease. In: Engel A, Larsson T, eds. Regional enteritis (Crohn's disease) (Skandia International Symposia 5). Stockholm: Nordiska Bokhandelns Forlag, 1971: 105-15."},{"key":"ref_13","article-title":"Crohn's disease in Stockholm County 19551974","volume":"490","author":"Hellers, G.","year":"1979","unstructured":"Hellers G. Crohn's disease in Stockholm County 19551974. Acta Chir Scand 1979; suppl 490.","journal-title":"Acta Chir Scand"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.21.6.525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:09:33Z","timestamp":1765073373000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.21.6.525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,6]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1980,6,1]]},"published-print":{"date-parts":[[1980,6]]}},"alternative-id":["10.1136\/gut.21.6.525"],"URL":"https:\/\/doi.org\/10.1136\/gut.21.6.525","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,6]]}}}