{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:50:52Z","timestamp":1763747452276,"version":"3.45.0"},"reference-count":8,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1981,11]]},"abstract":"<jats:p>Measurements were made of the amounts of histamine extracted from patients with peptic ulcer disease and control subjects suffering from various gastrointestinal diseases. Patients with duodenal ulcer, gastric ulcer, or recurrent duodenal ulcer after proximal gastric vagotomy often had less gastric mucosal histamine than did normal controls. Cimetidine therapy increased the amounts of the histamine to above control levels, presumably by suppression of output. It is concluded that endogenous amounts of histamine reflect the pathogenic states in the gastric mucosa of patients with peptic ulcer diseases. Cimetidine, as does vagotomy, increases the amount of gastric mucosal histamine. These findings suggest that the increase in mucosal histamine with cimetidine is not due to activation of histamine methyl transferase, but rather to suppression of histamine output into the gastric juice.<\/jats:p>","DOI":"10.1136\/gut.22.11.923","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"923-926","source":"Crossref","is-referenced-by-count":23,"title":["Effect of cimetidine on the amounts of histamine in the gastric mucosa of patients with gastric or duodenal ulcers."],"prefix":"10.1136","volume":"22","author":[{"given":"W K","family":"Man","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Ingoldby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/BF01469008","article-title":"Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases","volume":"54","author":"Troidl, H.; Lorenz, W.; Rohde, H.","year":"1976","unstructured":"Troidl H, Lorenz W, Rohde H et al. Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases. Klin Wschr 1976; 54:947-56.","journal-title":"Klin Wschr"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/bjs.1800650104","article-title":"Effect of selective gastric vagotomy on histamine concentration in gastric mucosa of patients with duodenal ulcer","volume":"65","author":"Troidl, H.; Rohdl, H.; Lorenz, W.","year":"1978","unstructured":"Troidl H, Rohdl H, Lorenz W et al. Effect of selective gastric vagotomy on histamine concentration in gastric mucosa of patients with duodenal ulcer. Br J Surg 1978; 65:10-16.","journal-title":"Br J Surg"},{"key":"ref_3","first-page":"452","article-title":"The effect of cimetidine and pentagastrin stimulation on the histamine concentration in the gastric mucosa of patients with peptic ulcer","volume-title":"Gut","volume":"21","author":"Saunders, J.H.; Man, W.K.; Spencer, J.","year":"1980","unstructured":"Saunders JH, Man WK, Spencer J. The effect of cimetidine and pentagastrin stimulation on the histamine concentration in the gastric mucosa of patients with peptic ulcer. Gut 1980; 21:A452."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF02024207","article-title":"Histamine and peptic ulcer: influence of sample-taking on the precision and accuracy of fluorometric histamine assay in biopsies of human gastric mucosa","volume":"10","author":"Rohde, H.; Lorenz, W.; Troidl, H.","year":"1980","unstructured":"Rohde H, Lorenz W, Troidl H et al. Histamine and peptic ulcer: influence of sample-taking on the precision and accuracy of fluorometric histamine assay in biopsies of human gastric mucosa. Agents Actions 1980; 10:175.","journal-title":"Agents Actions"},{"issue":"10","key":"ref_5","article-title":"Histamine, gastric secretion and peptic ulcer disease: An attempt to define special sources of error and problems in clinical-biochemical trials","volume":"1978","author":"Lorenz, W.; Troidl, H.; Barth, H.; Rohde, H.","year":"1978","unstructured":"Lorenz W, Troidl H, Barth H, Rohde H (1978) Histamine, gastric secretion and peptic ulcer disease: An attempt to define special sources of error and problems in clinical-biochemical trials. In: Creutzfeldt, W Cimetidine. ed. Amsterdam-Oxford Excerpta Medica,: 1978: 10.","journal-title":"Amsterdam-Oxford Excerpta Medica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/BF00309904","article-title":"Cellular localisation of histamine and monoamines in the gastric mucosa of man","volume":"18","author":"Hakanson, R.; Lilja, B.; Owman, C.","year":"1969","unstructured":"Hakanson R, Lilja B, Owman C. (1969). Cellular localisation of histamine and monoamines in the gastric mucosa of man. Histochemie 18:74-86.","journal-title":"Histochemie"},{"key":"ref_7","first-page":"596","article-title":"Prevention of stress ulcer by reducing gastric tissue histamine Surg","volume":"62","author":"Ritchie, W.P.; Breen, J.J.; Grigg, D.I.","year":"1967","unstructured":"Ritchie WP, Breen JJ, Grigg DI (1967). Prevention of stress ulcer by reducing gastric tissue histamine Surg 1967; 62:596-600."},{"key":"ref_8","first-page":"\"624","article-title":"Catecholamines and experimental stress ulcer: morphological and biochemical changes in the gastric mucosa","volume":"67","author":"M, Beraha N.Silveira; W, Man","year":"1980","unstructured":"Beraha N. Silveira M, Man W et al. Catecholamines and experimental stress ulcer: morphological and biochemical changes in the gastric mucosa. Br J Surg, 1980 67:624-8 9Barth H. Troidl H. Lorenz W et al. (1977). Histamine and peptic ulcer disease: histamine methyl transferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgery. Agents Actions 6:75-9.","journal-title":"Br J Surg; Histamine and peptic ulcer disease: histamine methyl transferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgery"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.22.11.923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:35:29Z","timestamp":1763746529000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.22.11.923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,11]]},"references-count":8,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1981,11,1]]},"published-print":{"date-parts":[[1981,11]]}},"alternative-id":["10.1136\/gut.22.11.923"],"URL":"https:\/\/doi.org\/10.1136\/gut.22.11.923","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1981,11]]}}}