{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:05:59Z","timestamp":1787699159388,"version":"build-2784847793"},"reference-count":11,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>An immunohistochemical technique is described for the detection of Mallory bodies (MBs) in paraffin sections of liver tissue. This is based on proteolytic digestion of sections before exposure to an antiserum which recognises a unique antigenic determinant in MBs. With the use of this procedure it has been shown in alcoholic liver disease, primary biliary cirrhosis. Indian childhood cirrhosis, Wilson's disease, diabetes mellitus, and hepatocellular cancer that the MBs found in these disorders contain this unique antigenic determinant. It is postulated, therefore, that the mechanism of formation of MBs is similar in liver diseases of diverse aetiology. In addition, it has been demonstrated that the immunohistochemical procedure is more sensitive than routine staining; MBs were detected in five out of 12 fatty livers by immunohistochemical and only in one by H and E staining. As MBs in fatty livers were not associated with polymorph filtration or fibrogenesis it is argued that MB formation is not an absolute prerequisite for the progression of acute to chronic liver disease.<\/jats:p>","DOI":"10.1136\/gut.22.5.341","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"341-344","source":"Crossref","is-referenced-by-count":26,"title":["Mallory bodies in alcoholic and non-alcoholic liver disease contain a common antigenic determinant."],"prefix":"10.1136","volume":"22","author":[{"given":"K A","family":"Fleming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Barbatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Canning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J O","family":"McGee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1981,5,1]]},"reference":[{"key":"ref_1","first-page":"646","article-title":"The pathogenesis of alcoholic cirrhosis In: Fisher MM, Rankin JG, eds. Alcohol and the liver","volume":"73","author":"Popper, H.","year":"1977","unstructured":"Popper, H. The pathogenesis of alcoholic cirrhosis In: Fisher MM, Rankin JG, eds. Alcohol and the liver. New York: Plenum Press, 1977; 289. 2van Waes L, Lieber CS. Early perivenular sclerosis in alcoholic fatty liver. Gastroenterology 1977; 73: 646-50.","journal-title":"Gastroenterology; 289. 2van Waes L, Lieber CS. Early perivenular sclerosis in alcoholic fatty liver"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0016-5085(76)80150-3","article-title":"Alcoholic hepatitis: cell mediated immunological response to alcoholic hyalin","volume":"70","author":"Zetterman, R.K.; Luisada-Opper, A.; Leevy, C.M.","year":"1976","unstructured":"Zetterman RK, Luisada-Opper A, Leevy CM. Alcoholic hepatitis: cell mediated immunological response to alcoholic hyalin. 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Proc Nat Acad Sci USA 1978; 75: 5034-8.","journal-title":"Proc Nat Acad Sci USA"},{"key":"ref_8","article-title":"Mallory bodies-immunohistochemical detection by antisera to unique non-prekeratin components","volume-title":"Gut","author":"Morton, J.A.; Fleming, K.A.; Trowell, J.M.; JO'D, McGee","year":"1981","unstructured":"Morton JA, Fleming KA, Trowell JM, and McGee JO'D. Mallory bodies-immunohistochemical detection by antisera to unique non-prekeratin components. Gut 1981."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.22.1.1","article-title":"Mallory bodies in alcoholic liver disease: Identification of cytoplasmic filaments\/ cell","volume":"22","author":"Morton, J.A.; Bastin, J.; Fleming, K.A.; McMichael, A.; Burns, J.; JO'D, McGee","year":"1981","unstructured":"Morton JA, Bastin J, Fleming KA, McMichael A, Burns J, McGee JO'D. Mallory bodies in alcoholic liver disease: Identification of cytoplasmic filaments\/ cell. Gut 1981; 22: 1-7.","journal-title":"Gut"},{"key":"ref_10","article-title":"Alcoholic hepatitis","volume-title":"Alcohol and the liver","author":"French, S.W.; Franks, Sim J.S.; KE, Burbidge; EJ, Denton; T, Caldwell; M.G.","year":"1977","unstructured":"French SW, Sim JS. Franks KE, Burbidge EJ, Denton T, Caldwell MG. Alcoholic hepatitis. In: Fisher MM, Rankin JG, eds. Alcohol and the liver. New York: Plenum Press, 1977; 261."},{"key":"ref_11","first-page":"178","article-title":"Collagen biosynthesis in hepatic fibrosis (abstr)","volume":"64","author":"Chen, T.; Leevy, C.M.","year":"1973","unstructured":"Chen T, Leevy CM. Collagen biosynthesis in hepatic fibrosis (abstr). Gastroenterology 1973; 64: 178.","journal-title":"Gastroenterology"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.22.5.341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:50:46Z","timestamp":1765007446000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.22.5.341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1981,5,1]]},"published-print":{"date-parts":[[1981,5]]}},"alternative-id":["10.1136\/gut.22.5.341"],"URL":"https:\/\/doi.org\/10.1136\/gut.22.5.341","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"value":"0017-5749","type":"print"},{"value":"1468-3288","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,5]]}}}