{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:54:21Z","timestamp":1765079661732,"version":"3.46.0"},"reference-count":15,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:p>Sixteen patients (aged 3.5-14.3 years) with normal jejunal mucosa, originally diagnosed as having coeliac disease at least 18 months before, were started on gluten challenge. The 'end point' of challenge was significant deterioration in jejunal mucosa morphologically and morphometrically. Studies carried out both before and after challenge included intestinal absorption of D-xylose and glucose, and release of insulin and N-terminal glucagon-like immunoreactivity (N-GLI). After gluten challenge, there were significant increases in plasma N-GLI at both 45 (P less than 0.05) and 120 minutes (P less than 0.03) after oral glucose. Significant reduction occurred in glucose absorption at 45 minutes (P less than 0.04), in one-hour D-xylose absorption (P less than 0.01) and fasting serum cholesterol (P less than 0.01). Plasma N-GLI showed significant negative correlations with D-xylose absorption (P less than 0.003) and serum cholesterol (P less than 0.004).<\/jats:p>","DOI":"10.1136\/gut.22.7.554","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"554-557","source":"Crossref","is-referenced-by-count":7,"title":["Changes in N-terminal glucagon-like immunoreactivity and insulin during short-term gluten challenge in childhood coeliac disease."],"prefix":"10.1136","volume":"22","author":[{"given":"D J","family":"Carson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"Glasgow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K D","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,7,1]]},"reference":[{"issue":"785-8","key":"ref_1","first-page":"\"2O'Connor\" # \"811.\"","article-title":"Impaired immunoreactive secretion release in coeliac disease","volume":"1","author":"FA, McLoughlin JC, Buchanan KD.","year":"1978","unstructured":"Besterman HS, Bloom SR, Sarson DL, Blackburn AM, Johnston DI, Patel HR, et al. Coeliac disease. Lancet 1978; 1: 785-8. 2O'Connor FA, McLoughlin JC, Buchanan KD. Impaired immunoreactive secretion release in coeliac disease. Br Med J 1977; 1: 811.","journal-title":"Coeliac disease. Lancet"},{"key":"ref_2","first-page":"461","article-title":"Diagnostic criteria in coeliac disease","volume":"59","author":"Meeuwisse, G.W.","year":"1970","unstructured":"Meeuwisse GW. Diagnostic criteria in coeliac disease. Acta Paediatr Scand 1970; 59: 461-3.","journal-title":"Acta Paediatr Scand"},{"key":"ref_3","first-page":"1043","article-title":"Onehour blood-xylose screening test for coeliac disease","volume":"2","author":"Rolles, C.J.; Kendall, M.J.; Nutter, S.; Anderson, C.M.","year":"1973","unstructured":"Rolles CJ, Kendall MJ, Nutter S, Anderson CM. Onehour blood-xylose screening test for coeliac disease. 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Queen's University of Belfast: Thesis 1971. '`Flanagan RWJ, Buchanan KD, Murphy RF. Specificity of antibodies in radioimmunoassay ofglucagon","volume":"10","author":"McCarroll, A.M.","year":"1974","unstructured":"McCarroll AM. Insulin clearance by the isolated perfused rat liver. Queen's University of Belfast: Thesis 1971. '`Flanagan RWJ, Buchanan KD, Murphy RF. Specificity of antibodies in radioimmunoassay ofglucagon. Diabetologia 1974; 10: 365.","journal-title":"Diabetologia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0005-2795(73)90153-0","article-title":"Isolation of glucagon-like immunoreactivity of gut by affinity chromatography on anti-glucagon antibodies coupled to sepharose 4B","volume":"303","author":"Murphy, R.F.; Buchanan, K.D.; Elmore, D.T.","year":"1973","unstructured":"Murphy RF, Buchanan KD, Elmore DT. Isolation of glucagon-like immunoreactivity of gut by affinity chromatography on anti-glucagon antibodies coupled to sepharose 4B. 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Clin Sci 1976; 51: 177-83.","journal-title":"Clin Sci"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1136\/gut.13.7.520","article-title":"An enteroglucagon tumour","volume":"13","author":"Bloom, SR","year":"1972","unstructured":"Bloom SR. An enteroglucagon tumour. Gut 1972; 13: 520-3.","journal-title":"Gut"},{"key":"ref_13","first-page":"14","article-title":"Does enteroglucagon play a trophic role in intestinal adaptation?","volume":"50","author":"Jacobs, L.R.; Polak, J.; Bloom, SR, Dowling; R.H.","year":"1976","unstructured":"Jacobs LR, Polak J, Bloom SR, Dowling RH. Does enteroglucagon play a trophic role in intestinal adaptation? Clin Sci Molec Med 1976; 50: 14p-15p.","journal-title":"Clin Sci Molec Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/gut.20.8.653","article-title":"Distribution of gut hormones in the primate intestinal tract","volume":"20","author":"Bryant, M.G.; Bloom, SR","year":"1979","unstructured":"Bryant MG, Bloom SR. Distribution of gut hormones in the primate intestinal tract. Gut 1979; 20: 653-9.","journal-title":"Gut"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/adc.50.4.259","article-title":"Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy","volume":"50","author":"Rolles, C.J.; Anderson, C.M.; McNeish, A.S.","year":"1975","unstructured":"'Rolles CJ, Anderson CM, McNeish AS. Confirming persistence of gluten intolerance in children diagnosed as having coeliac disease in infancy. Arch Dis Child 1975; 50: 259-63.","journal-title":"Arch Dis Child"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.22.7.554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:29:47Z","timestamp":1765074587000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.22.7.554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7]]},"references-count":15,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1981,7,1]]},"published-print":{"date-parts":[[1981,7]]}},"alternative-id":["10.1136\/gut.22.7.554"],"URL":"https:\/\/doi.org\/10.1136\/gut.22.7.554","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1981,7]]}}}