{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:33:32Z","timestamp":1765010012871,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gut"],"published-print":{"date-parts":[[1981,8]]},"abstract":"<jats:p>Previous investigations have shown that patients with fulminant hepatic failure after halothane anaesthesia have a circulating antibody which reacts with an antigen present on the surface of halothane-altered hepatocytes. In the present study, it has been shown that the expression of the antigen is associated with the oxidative metabolism of halothane, in contrast with results of other groups which have shown that the reductive route is involved in the direct hepatotoxic reaction attributed to halothane.<\/jats:p>","DOI":"10.1136\/gut.22.8.669","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:41:31Z","timestamp":1190137291000},"page":"669-672","source":"Crossref","is-referenced-by-count":59,"title":["Oxidative metabolism of halothane in the production of altered hepatocyte membrane antigens in acute halothane-induced hepatic necrosis"],"prefix":"10.1136","volume":"22","author":[{"given":"J","family":"Neuberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgina","family":"Mieli-Vergani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Tredger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00000542-197612000-00005","article-title":"An animal model of hepatotoxicity associated with halothane anaesthesia","volume":"45","author":"Sipes, I.G.; Brown, B.R.","year":"1976","unstructured":"Sipes IG, Brown BR. An animal model of hepatotoxicity associated with halothane anaesthesia. Anesthesiology 1976; 45:622-8.","journal-title":"Anesthesiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/0310057X7900700102","article-title":"Hepatotoxicity and halothane metabolism in an animal model with application for human toxicity","volume":"7","author":"Cousins, M.S.; Sharp, J.H.; Gourlay, G.K.; Adams, J.F.; Haynes, W.D.; Whitehead, R.","year":"1979","unstructured":"Cousins MS, Sharp JH, Gourlay GK, Adams JF, Haynes WD, Whitehead R. Hepatotoxicity and halothane metabolism in an animal model with application for human toxicity. Anaesth Intensive Care 1979; 7: 9-24.","journal-title":"Anaesth Intensive Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00000542-197707000-00005","article-title":"Halothane hepatotoxicity enhancement by polychlorinated biphenyl pretreatment","volume":"47","author":"Reynolds, E.S.; Moslen, M.T.","year":"1977","unstructured":"Reynolds ES, Moslen MT. Halothane hepatotoxicity enhancement by polychlorinated biphenyl pretreatment. Anesthesiology 1977; 47: 19-27.","journal-title":"Anesthesiology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1136\/bmj.1.6019.1171","article-title":"Unexplained hepatitis following halothane","volume":"1","author":"Walton, B.; Simpson, B.R.; Strunin, L.; Doniach, D.; Perrin, S.; Appleyard, A.J.","year":"1976","unstructured":"Walton B, Simpson BR, Strunin L, Doniach D, Perrin S, Appleyard AJ. Unexplained hepatitis following halothane. Br Med J 1976; 1: 1171-6.","journal-title":"Br Med J"},{"key":"ref_5","first-page":"801","article-title":"Sensitisation to halothane-altered liver components in severe hepatic necrosis after halothane anaesthesia","volume":"2","author":"Vergani, D.; Tsantoulas, D.; Eddleston, A.L.W.F.; Davis, M.; Williams, R.","year":"1978","unstructured":"Vergani D, Tsantoulas D, Eddleston ALWF, Davis M, Williams R. Sensitisation to halothane-altered liver components in severe hepatic necrosis after halothane anaesthesia. Lancet 1978; 2: 801-3.","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1056\/NEJM198007103030202","article-title":"Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis","volume":"303","author":"Vergani, D.; Mieli-Vergani, G.; Alberti, A.; Neuberger, J.M.; Eddleston, A.L.W.F.; Davis, M.; Williams, R.","year":"1980","unstructured":"Vergani D, Mieli-Vergani G, Alberti A, Neuberger JM, Eddleston ALWF, Davis M, Williams R. Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis. N Engl J Med 1980; 303: 66-1.","journal-title":"N Engl J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00000542-197603000-00004","article-title":"Hypoxia and halothane metabolism in vivo","volume":"44","author":"Widger, L.A.; Gandolfi, A.J.; van Dyke, R.A.","year":"1976","unstructured":"Widger LA, Gandolfi AJ, van Dyke RA. Hypoxia and halothane metabolism in vivo. Anesthesiology 1976; 44: 197-201.","journal-title":"Anesthesiology"},{"key":"ref_8","first-page":"619","article-title":"Recent molecular theories of general anaesthesia","volume":"51","author":"Wardley-Smith, B.; Halsey, M.J.","year":"1979","unstructured":"Wardley-Smith B, Halsey MJ. Recent molecular theories of general anaesthesia. BrJAnaesth 1979; 51: 619-26.","journal-title":"BrJAnaesth"},{"key":"ref_9","first-page":"\"1","article-title":"Antigens of the human liver. Clin Exp Immunol 1980; 40","volume":"1","author":"McFarlane, I.G.; Wojcicka, B.; Williams, R.","year":"1975","unstructured":"McFarlane IG, Wojcicka B, Williams R. Antigens of the human liver. Clin Exp Immunol 1980; 40:1-7. `Trowell J, Peto R, Crampton-Smith A. Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium. Lancet 1975; 1:821-4.","journal-title":"Lancet; Controlled trial of repeated halothane anaesthetics in patients with carcinoma of the uterine cervix treated with radium"},{"key":"ref_10","first-page":"817","article-title":"Controlled prospective study of the effect on liver function of multiple exposures to halothane","volume":"1","author":"Wright, R.; Eade, O.E.; Chisholm, O.M.; Hawksley, M.; Lloyd, B.; Moles, T.M.; Edwards, J.C.; Gardner, M.J.","year":"1975","unstructured":"Wright R, Eade OE, Chisholm OM, Hawksley M, Lloyd B, Moles TM, Edwards JC, Gardner MJ. Controlled prospective study of the effect on liver function of multiple exposures to halothane. Lancet 1975; 1: 817-20.","journal-title":"Lancet"},{"key":"ref_11","first-page":"\"382","article-title":"303: 1123. `Zimmerman HJ. In: Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver","volume":"50","author":"Davis, M.; Eddleston, A.L.W.F.; Neuberger, J.M.; MieliVergani, G.; Vergani, D.; Williams, R.","year":"1980","unstructured":"Davis M, Eddleston ALWF, Neuberger JM, MieliVergani G, Vergani D, Williams R. N Engi J Med 1980; 303:1123. `Zimmerman HJ. In: Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. New York: Appleton-Century Crofts, 1978: 382-3. `Sharp JH, Trudell JH, Cohen EN. Volatile metabolites and decomposition products of halothane in man. Anesthesiology 1970; 50: 2-8.","journal-title":"N Engi J Med; Sharp JH, Trudell JH, Cohen EN. Volatile metabolites and decomposition products of halothane in man"}],"container-title":["Gut"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/gut.22.8.669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:29:04Z","timestamp":1765009744000},"score":1,"resource":{"primary":{"URL":"https:\/\/gut.bmj.com\/lookup\/doi\/10.1136\/gut.22.8.669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,8]]},"references-count":11,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1981,8,1]]},"published-print":{"date-parts":[[1981,8]]}},"alternative-id":["10.1136\/gut.22.8.669"],"URL":"https:\/\/doi.org\/10.1136\/gut.22.8.669","relation":{},"ISSN":["0017-5749","1468-3288"],"issn-type":[{"type":"print","value":"0017-5749"},{"type":"electronic","value":"1468-3288"}],"subject":[],"published":{"date-parts":[[1981,8]]}}}